Detection of Myositis Autoantibodies by Multi-Analytic Immunoassays in a Large Multicenter Cohort of Patients with Definite Idiopathic Inflammatory Myopathies

Article Medicine, General & Internal

Deciphering the Autoantibody Response to the OJ Antigenic Complex

Marvin J. Fritzler et al.

Summary: This study found that the combination of IARS and KARS antigens can effectively detect anti-OJ antibodies, providing a promising approach for automated antibody detection.

DIAGNOSTICS (2023)

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Article Rheumatology

Mass spectrometry-based identification of new anti-Ly and known antisynthetase autoantibodies

Jean-Baptiste Vulsteke et al.

Summary: New and known antisynthetase autoantibodies (ASAs) were discovered and detected through protein immunoprecipitation combined with gel-free liquid chromatography-tandem mass spectrometry (IP-MS). The dominant cognate ARS autoantigen of the newly discovered anti-Ly ASA specificity was identified. Unbiased and targeted IP-MS are promising methods for discovery and detection of autoantibodies.

ANNALS OF THE RHEUMATIC DISEASES (2023)

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Review Rheumatology

Update on autoantibodies and related biomarkers in autoimmune inflammatory myopathies

May Y. Choi et al.

Summary: The spectrum of autoantibodies and related biomarkers in AIM continues to expand. Many of these have clear clinical implications in regard to subsets and overlap conditions of AIM, associated malignancy and pathological findings.

CURRENT OPINION IN RHEUMATOLOGY (2023)

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Article Medicine, General & Internal

[18F]FDG-PET/CT in Idiopathic Inflammatory Myopathies: Retrospective Data from a Belgian Cohort

Halil Yildiz et al.

Summary: The study found that [F-18]FDG-PET/CT is a useful tool for diagnosing PM, DM, cancer, and interstitial lung diseases (ILDs) in IIMs. Through a retrospective analysis of Belgian IIMs patients, it was found that among 27 patients, 7 had ILDs, 3 had cancer, and 13 had abnormal muscle FDG uptake compatible with myositis.

DIAGNOSTICS (2023)

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Article Rheumatology

Interstitial lung disease with and without progressive fibrosing phenotype in patients with idiopathic inflammatory myopathies: data from a large multicentric cohort

Elisabetta Zanatta et al.

Summary: Patients with connective tissue diseases, specifically idiopathic inflammatory myopathies, are at risk of developing interstitial lung disease (ILD), with some cases progressing to a fibrosing ILD phenotype (PF-ILD). This study aimed to investigate the occurrence and factors predicting PF-ILD in IIMs, as well as assess the radiological pattern and associated factors of IIMs-ILD.

RMD OPEN (2023)

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Article Rheumatology

Myositis autoantibodies detected by line blot immunoassay: clinical associations and correlation with antibody signal intensity

Jesus Loarce-Martos et al.

Summary: The aim of this study is to assess the relationship between myositis specific (MSA) and myositis associated (MAA) antibodies and diagnosis, and to explore the impact of antibody signal intensity in diagnostic accuracy. The study analyzed serum samples obtained from patients tested for MSA/MAA, and found that strongly positive antibodies were more frequently associated with true positive cases, while weak positives were more common in false positive cases. Clinical false positives were associated with negative ANA, low ANA titer, and multiple positive MSA/MAA.

RHEUMATOLOGY INTERNATIONAL (2023)

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Article Allergy

An Italian Multicenter Study on Anti-NXP2 Antibodies: Clinical and Serological Associations

Micaela Fredi et al.

Summary: This collaborative project aimed to analyze the clinical features associated with anti-NXP2 antibodies. The results showed that NXP2-positive patients were more common in younger age groups, and were associated with dermatomyositis and inclusion-body myositis, while having a lower incidence of anti-synthetase syndrome. Commercial line blot and immunoprecipitation (IP) can be used to detect NXP2 antibodies, but confirmation through other methods is necessary.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Review Immunology

An updated review of anti-Ro52 (TRIM21) antibodies impact in connective tissue diseases clinical management

P. Decker et al.

Summary: Anti-Ro52 antibodies are commonly found in patients with connective tissue diseases and are associated with certain clinical features and survival. They may have a role in the inflammatory response.

AUTOIMMUNITY REVIEWS (2022)

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Article Rheumatology

Autoantibodies: Pathogenic or epiphenomenon

Angeles S. Galindo-Feria et al.

Summary: Idiopathic inflammatory myopathies (IIM) are a group of heterogeneous autoimmune diseases, with distinct subgroups. The presence and importance of autoantibodies in patients are increasingly recognized.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2022)

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Review Rheumatology

Anti-MDA5 dermatomyositis: an update from bench to bedside

Enrico Fuzzi et al.

Summary: This review provides a comprehensive summary of recent developments in anti-MDA5 antibody positive dermatomyositis, focusing on its pathogenesis, clinical features, and treatment options, particularly the rapidly progressive interstitial lung disease, which is its most severe complication. Recent findings suggest that the clinical spectrum of anti-MDA5+ dermatomyositis is diverse, with different patient subsets exhibiting varied outcomes, and severe acute interstitial lung disease being the main determinant of prognosis. The role of anti-MDA5 antibodies in the pathogenesis is an active area of research. Early identification of atypical presentations and aggressive immunosuppression in cases of acute interstitial lung involvement offer the best chances of survival.

CURRENT OPINION IN RHEUMATOLOGY (2022)

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Letter Immunology

Two novel anti-aminoacyl tRNA synthetase antibodies: Autoantibodies against cysteinyl-tRNA synthetase and valyl-tRNA synthetase

Yoshinao Muro et al.

Summary: Anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies are helpful in identifying inflammatory myopathy patients. In a study with Japanese patients, autoantibodies against CysARS and ValARS were found in the serum of two dermatomyositis patients. One patient showed features of anti-synthetase syndrome, while the other did not. Further research is needed to explore the clinical differences among different anti-ARS antibodies.

AUTOIMMUNITY REVIEWS (2022)

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Article Rheumatology

Multiparametric autoantibody analysis: a new paradigm for the diagnosis of connective tissue diseases

Nicola Bizzaro et al.

Summary: This study evaluated the utility of multiparametric autoantibody analysis in patients with connective tissue diseases (CTDs). The results showed that enlarged autoantibody profiles have a higher diagnostic efficiency and that multiple positive autoantibodies increase the chances of disease.

ARTHRITIS RESEARCH & THERAPY (2022)

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Article Immunology

Positioning of myositis-specific and associated autoantibody (MSA/MAA) testing in disease criteria and routine diagnostic work-up

Carolien Bonroy et al.

Summary: The importance of detecting myositis-specific antibodies (MSA) and myositis-associated antibodies (MAA) in the diagnosis and classification of idiopathic inflammatory myopathy (IIM) is widely acknowledged by experts. However, the lack of sufficient data on MSA/MAA in large cohorts has hindered their inclusion in data-based classification criteria. In addition, commercially available assays for detecting MSA/MAA show variable performance characteristics, which poses challenges for future studies and routine clinical use. Collaboration between clinical experts, laboratory professionals, and diagnostic companies is encouraged to overcome these hurdles.

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2022)

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Letter Rheumatology

Standardisation of myositis-specific antibodies: where are we today?

Michael Mahler et al.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Review Rheumatology

Assessment of diagnostic utility, clinical phenotypic associations, and prognostic significance of anti-NXP2 autoantibody in patients with idiopathic inflammatory myopathies: a systematic review and meta-analysis

Liubing Li et al.

Summary: The study found a significant association between anti-nuclear matrix protein 2 (NXP2) autoantibody and idiopathic inflammatory myopathies (IIMs), especially in juvenile IIMs. Anti-NXP2 autoantibody was found to be related to symptoms such as edema, muscle weakness, myalgia/myodynia, dysphagia, calcinosis, and interstitial lung disease (ILD) in patients with IIMs, but there was no evidence to suggest a poor prognosis in terms of overall survival.

CLINICAL RHEUMATOLOGY (2021)

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Article Medicine, General & Internal

Profiling of Myositis Specific Antibodies and Composite Scores as an Aid in the Differential Diagnosis of Autoimmune Myopathies

Michael Mahler et al.

Summary: The study evaluated the clinical performance and diagnostic value of MSA profiled by PMAT in IIM patients, indicating that MSA, especially when combined in composite scores, provide significant value in stratifying patients with IIM.

DIAGNOSTICS (2021)

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Article Allergy

Predictive Features and Clinical Presentation of Interstitial Lung Disease in Inflammatory Myositis

Tamara Vojinovic et al.

Summary: Interstitial lung disease (ILD) occurs in about one third of patients with idiopathic inflammatory myositis (IIM), predominantly affecting those with anti-synthetase syndrome. ILD patterns in IIM patients include non-specific interstitial pneumonia (NSIP), organizing pneumonia (OP), and usual interstitial pneumonia-like (UIP). ILD onset is associated with dyspnea and anti-Ro52 antibodies, with the latter predicting a significant improvement in DLCO during follow-up.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2021)

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Review Rheumatology

Immune-mediated necrotizing myopathy: clinical features and pathogenesis

Yves Allenbach et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Anti-Ro52 antibody is an independent risk factor for interstitial lung disease in dermatomyositis

Xiaojing Xing et al.

RESPIRATORY MEDICINE (2020)

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Article Rheumatology

Line blot immunoassays in idiopathic inflammatory myopathies: retrospective review of diagnostic accuracy and factors predicting true positive results

Fergus To et al.

BMC RHEUMATOLOGY (2020)

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Letter Rheumatology

Detection of myositis-specific antibodies

Jean-Baptiste Vulsteke et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

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Letter Rheumatology

Detection of myositis-specific antibodies: additional notes

Michael Mahler et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

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Review Immunology

Anti-OJ autoantibodies: Rare or underdetected?

Jean-Baptiste Vulsteke et al.

AUTOIMMUNITY REVIEWS (2019)

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Letter Clinical Neurology

Autoantibodies at the Center of (sub)Classification-Issues of Detection

Jean-Baptiste Vulsteke et al.

JAMA NEUROLOGY (2019)

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Article Biochemical Research Methods

Evaluation of a novel particle-based assay for detection of autoantibodies in idiopathic inflammatory myopathies

I Cavazzana et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2019)

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Review Immunology

Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays

Jan Damoiseaux et al.

AUTOIMMUNITY REVIEWS (2019)

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Review Rheumatology

The diagnostic work-up of cancer-associated myositis

Albert Selva-O'Callaghan et al.

CURRENT OPINION IN RHEUMATOLOGY (2018)

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Review Rheumatology

Autoantibodies in myositis

Neil J. McHugh et al.

NATURE REVIEWS RHEUMATOLOGY (2018)

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Review Rheumatology

The clinico-serological spectrum of overlap myositis

Micaela Fredi et al.

CURRENT OPINION IN RHEUMATOLOGY (2018)

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Article Clinical Neurology

Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies

Kuberaka Mariampillai et al.

JAMA NEUROLOGY (2018)

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Article Immunology

Anti-HMGCR antibodies demonstrate high diagnostic value in the diagnosis of immune-mediated necrotizing myopathy following statin exposure

O. Shovman et al.

IMMUNOLOGIC RESEARCH (2017)

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Article Rheumatology

2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups

Ingrid E. Lundberg et al.

ARTHRITIS & RHEUMATOLOGY (2017)

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Article Rheumatology

2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups

Ingrid E. Lundberg et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

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Article Medical Laboratory Technology

Detection of autoantibodies to 3-hydroxy-3-methylglutaryl-coenzyme a reductase by ELISA in a reference laboratory setting

Troy D. Jaskowski et al.

CLINICA CHIMICA ACTA (2017)

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Review Immunology

Anti-HMGCR antibodies as a biomarker for immune-mediated necrotizing myopathies: A history of statins and experience from a large international multi-center study

Lucile Musset et al.

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Article Immunology

The clinical features, diagnosis and classification of dermatomyositis

Luca Iaccarino et al.

JOURNAL OF AUTOIMMUNITY (2014)

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Article Immunology

Analysis of Autoantibodies to 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Using Different Technologies

Lucile Musset et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

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Review Immunology

Myositis autoantibodies and clinical phenotypes

Anna Ghirardello et al.

AUTOIMMUNITY HIGHLIGHTS (2014)

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Review Immunology

Overlap connective tissue disease syndromes

Luca Iaccarino et al.

AUTOIMMUNITY REVIEWS (2013)

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Rituximab in refractory idiopathic inflammatory myopathies and antisynthetase syndrome: personal experience and review of the literature

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IMMUNOLOGIC RESEARCH (2013)

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Article Rheumatology

Autoantibodies in Polymyositis and Dermatomyositis

Anna Ghirardello et al.

CURRENT RHEUMATOLOGY REPORTS (2013)

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Article Respiratory System

Myositis-related interstitial lung disease and antisynthetase syndrome

Joshua Solomon et al.

JORNAL BRASILEIRO DE PNEUMOLOGIA (2011)

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Article Critical Care Medicine

Interstitial Lung Disease Associated With the Idiopathic Inflammatory Myopathies What Progress Has Been Made in the Past 35 Years?

Geoffrey R. Connors et al.

CHEST (2010)

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Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay

Anna Ghirardello et al.

RHEUMATOLOGY (2010)

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OxLDL/β2GPI-anti-oxLDL/β2GPI complex and atherosclerosis in SLE patients

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Potential off-label use of infliximab in autoimmune and non-autoimmune diseases: a review

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Detection of Myositis Autoantibodies by Multi-Analytic Immunoassays in a Large Multicenter Cohort of Patients with Definite Idiopathic Inflammatory Myopathies

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