Eccrine Poroma: Pathogenesis, New Diagnostic Tools and Association with Porocarcinoma-A Review

Eccrine poroma (EP) is a relatively rare benign adnexal neoplasm that usually affects elderly patients. Its pathogenesis is still under investigation, but recent gene studies have revealed gene fusions as key incidences resulting in oncogenetic pathways. It often presents as a solitary, firm papule, mostly asymptomatic, located on the soles or palms. Due to its clinical and dermoscopic variability, it is characterized as the great imitator. We performed a literature review, aiming to summarize current data on the pathogenetic mechanisms, new dermoscopic features, and novel diagnostic tools that may aid in early diagnosis and proper management of this rare adnexal tumor. Furthermore, we reviewed the possible pathogenetic associations between EP and its malignant counterpart, namely eccrine porocarcinoma. This systematic approach may aid in understanding the pathogenetic mechanisms and how to use novel histopathologic markers and imaging methods to overcome the diagnostic dilemma of this rare tumor.

Automated summary

Eccrine poroma is a rare benign adnexal tumor that mainly affects elderly patients. Its pathogenesis is still being investigated and recent gene studies have identified gene fusions as key factors in the development of this tumor. It often presents as a solitary, firm papule on the soles or palms and is known for its clinical and dermoscopic variability. This literature review summarizes current knowledge on the pathogenesis, dermoscopic features, and diagnostic methods for early diagnosis and proper management of this rare tumor, as well as the possible associations between eccrine poroma and its malignant counterpart, eccrine porocarcinoma.