4.6 Article

Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation

Jennifer R. Deuis et al.

Summary: A peptide named β-theraphotoxin-Eo1a was discovered from the venom of the Tanzanian black and olive baboon tarantula, which modulates the function of Na(V)1.8 channels. Eo1a increases the peak current of Na(V)1.8 and causes significant shifts in the voltage-dependence of activation and steady-state fast inactivation.

FRONTIERS IN PHARMACOLOGY (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

pHLIP Peptides Target Acidity in Activated Macrophages

Hannah Visca et al.

Summary: This study demonstrates the effective targeting of activated macrophages using pHLIP technology, which has important implications for screening and treatment in specific diseased tissues.

MOLECULAR IMAGING AND BIOLOGY (2022)

Article Engineering, Biomedical

Improving Cancer Detection and Treatment by pH-Sensitive Peptide Nanoparticle Drug Delivery Platform: Pharmacokinetics, Toxicity, and Immunogenicity Profile

Hoon Choi et al.

Summary: This study demonstrates that a peptide-based nanodelivery platform can improve cancer diagnosis and treatment, particularly showing excellent sensitivity to drug-resistant triple-negative breast cancer. The investigation also confirms that pH-NP nanoparticles are non-immunogenic and well-tolerated.

ADVANCED NANOBIOMED RESEARCH (2022)

Article Anesthesiology

A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome

Fernanda C. Cardoso et al.

Summary: The discovery of two novel tarantula-venom peptides, Tap1a and Tap2a, provides potential treatment for chronic visceral pain by modulating the activity of Na-v and Ca(v)3 channels. Tap1a, in particular, shows significant analgesic effects in a mouse model, suggesting a new therapeutic approach for chronic pain.
Article Pharmacology & Pharmacy

Recombinant production, bioconjugation and membrane binding studies of Pn3a, a selective NaV1.7 inhibitor

Gagan Sharma et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

The influence of proline isomerization on potency and stability of anti-HIV antibody 10E8

Miklos Guttman et al.

SCIENTIFIC REPORTS (2020)

Review Food Science & Technology

The Role of Toxins in the Pursuit for Novel Analgesics

Yossi Maatuf et al.

TOXINS (2019)

Article Biochemistry & Molecular Biology

Activity and characterization of a pH-sensitive antimicrobial peptide

Morgan A. Hitchner et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

Article Biochemistry & Molecular Biology

Peptide therapeutics from venom: Current status and potential

Michael W. Pennington et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

Akello J. Agwa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors

Linden C. Wyatt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death

Kay L. Richards et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Proline Residues as Switches in Conformational Changes Leading to Amyloid Fibril Formation

Ajda Taler-Vercic et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Pharmacology & Pharmacy

NaV1.7 as a pain target - From gene to pharmacology

Irina Vetter et al.

PHARMACOLOGY & THERAPEUTICS (2017)

Article Multidisciplinary Sciences

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Irene R. Chassagnon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

Jennifer R. Deuis et al.

SCIENTIFIC REPORTS (2017)

Article Pharmacology & Pharmacy

Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus

Fernanda C. Cardoso et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Multidisciplinary Sciences

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

Jeremiah D. Osteen et al.

NATURE (2016)

Article Multidisciplinary Sciences

Novel pH-Sensitive Cyclic Peptides

Dhammika Weerakkody et al.

SCIENTIFIC REPORTS (2016)

Article Chemistry, Multidisciplinary

Reversible Activation of a Cell-Penetrating Peptide in a Membrane Environment

Denise K. Schach et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Review Physiology

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

Calvin R. Justus et al.

FRONTIERS IN PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Cis-trans peptide variations in structurally similar proteins

Agnel Praveen Joseph et al.

AMINO ACIDS (2012)

Article Clinical Neurology

A Novel Nav1.7 Mutation Producing Carbamazepine-Responsive Erythromelalgia

Tanya Z. Fischer et al.

ANNALS OF NEUROLOGY (2009)

Article Multidisciplinary Sciences

Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo

Oleg A. Andreev et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Pharmacology & Pharmacy

Voltage-gated ion channels and gating modifier toxins

William A. Catterall et al.

TOXICON (2007)

Article Multidisciplinary Sciences

An SCN9A channelopathy causes congenital inability to experience pain

James J. Cox et al.

NATURE (2006)

Article Multidisciplinary Sciences

Spider toxins activate the capsaicin receptor to produce inflammatory pain

Jan Siemens et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Solution structure and functional characterization of SGTxl, a modifier of Kv2.1 channel gating

CW Lee et al.

BIOCHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Two tarantula peptides inhibit activation of multiple sodium channels

RE Middleton et al.

BIOCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHs

MJ Turk et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)