Journal
NATURE METHODS
Volume 14, Issue 1, Pages 61-64Publisher
NATURE RESEARCH
DOI: 10.1038/nmeth.4083
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Funding
- Fund for Medical Discovery Award from the Executive Committee on Research of Massachusetts General Hospital
- Stanley Center at the Broad Institute of MIT and Harvard
- Broadnext10 Grant from the Broad Institute of MIT and Harvard
- NIMH [1R01MH109903]
- Lundbeck Foundation
- Novo Nordisk Foundation [NNF14CC0001]
- [1P01HD068250]
- Novo Nordisk Foundation Center for Protein Research [PI S�ren Brunak] Funding Source: researchfish
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P01HD068250] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH109903] Funding Source: NIH RePORTER
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Genome-scale human protein-protein interaction networks are critical to understanding cell biology and interpreting genomic data, but challenging to produce experimentally. Through data integration and quality control, we provide a scored human protein-protein interaction network (InWeb_InBioMap, or InWeb_IM) with severalfold more interactions (>500,000) and better functional biological relevance than comparable resources. We illustrate that InWeb_InBioMap enables functional interpretation of >4,700 cancer genomes and genes involved in autism.
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