Journal
NATURE METHODS
Volume 13, Issue 7, Pages 563-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3871
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Funding
- US National Institutes of Health (NIH) National Human Genome Research Institute [P50 HG005550]
- Wyss Institute for Biologically Inspired Engineering
- National Cancer Institute [5T32CA009216-34]
- Banting postdoctoral fellowship from the Canadian Institutes of Health Research
- Defense Threat Reduction Agency [HDTRA1-14-1-0006]
- NIH under Ruth L. Kirschstein National Research Service Award from the NIH General Medical Sciences Division [F32GM113395]
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Several programmable transcription factors exist based on the versatile Cas9 protein, yet their relative potency and effectiveness across various cell types and species remain unexplored. Here, we compare Cas9 activator systems and examine their ability to induce robust gene expression in several human, mouse, and fly cell lines. We also explore the potential for improved activation through the combination of the most potent activator systems, and we assess the role of cooperativity in maximizing gene expression.
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