4.5 Article

Ex vivo cultivated retinal pigment epithelial cell transplantation for the treatment of rabbit corneal endothelial dysfunction

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide

Zongyi Li et al.

Summary: Injection of human pluripotent stem cell-derived corneal endothelial precursors (CEPs) and nicotinamide (NAM) can effectively treat corneal endothelial dysfunction, and the transplanted cells can integrate with host resident cells.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Article Ophthalmology

Functional assessment of cryopreserved clinical grade hESC-RPE cells as a qualified cell source for stem cell therapy of retinal degenerative diseases

Qi-You Li et al.

Summary: The study found that cryopreserved hESC-RPE cells retained specific gene expression, morphology, and functions similar to induced RPE cells, including phagocytic capability. However, the secretion of PEDF was significantly reduced in cryopreserved hESC-RPE cells. In rat experiments, there was an initial decrease in b-wave amplitude at 4 weeks post transplantation with cryopreserved hESC-RPE cells compared to induced cells, but no significant differences were observed at 8 and 12 weeks. This indicates that cryopreserved hESC-RPE cells are still suitable for cell-based therapy in retinal degenerative diseases even after cryopreservation and thawing.

EXPERIMENTAL EYE RESEARCH (2021)

Article Ophthalmology

Five-Year Follow-up of First 11 Patients Undergoing Injection of Cultured Corneal Endothelial Cells for Corneal Endothelial Failure

Kohsaku Numa et al.

Summary: The study reports the long-term safety and efficacy of a novel cell injection therapy using cultured human corneal endothelial cells for endothelial failure conditions. Results showed successful restoration of corneal endothelial function in most cases, along with significant improvement in visual acuity. No major adverse reactions were observed, confirming the therapy's safety and efficacy up to 5 years postoperatively.

OPHTHALMOLOGY (2021)

Article Biochemistry & Molecular Biology

The Influence of Melatonin and Light on VEGF Secretion in Primary RPE Cells

Alexa Klettner et al.

Summary: The research found that the VEGF secretion of retinal pigment epithelial cells is influenced by diurnal rhythm, with increased secretion when melatonin is combined with morning daylight. This reveals a new mechanism of VEGF regulation in the retina.

BIOMOLECULES (2021)

Article Cell & Tissue Engineering

Transplantation of human induced pluripotent stem cell-derived neural crest cells for corneal endothelial regeneration

Yajie Gong et al.

Summary: Transplantation of hiPSC-derived NCCs can rapidly restore rabbit corneal thickness and clarity, but long-term recovery efficacy may be impaired by factors such as improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.

STEM CELL RESEARCH & THERAPY (2021)

Review Cell Biology

S100A4 in the Physiology and Pathology of the Central and Peripheral Nervous System

Nadia D'Ambrosi et al.

Summary: S100A4, a member of the S100 protein family, plays diverse roles in different cellular contexts; while it has been primarily associated with tumorigenesis and metastasis, it also plays a key role in promoting inflammation in various organs; in the nervous system, S100A4 contributes to neurogenesis, cellular motility, and inflammatory responses.

CELLS (2021)

Article Cell & Tissue Engineering

Pluripotent stem cell-derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty

Muhammad Ali et al.

Summary: The study evaluated the efficacy of cryopreserved human embryonic stem cell-derived corneal endothelial cells in forming a functional corneal endothelium in rabbits and monkeys. Results showed clear corneas and intact cell structures post-injection, with no remarkable changes in tissue indicating teratoma formation. This suggests the potential of using cryopreserved hESC-derived CECs in repairing Descemet's membrane and restoring corneal function.

STEM CELL REPORTS (2021)

Review Ophthalmology

Use of biomaterials in corneal endothelial repair

Noor Ahmed Hussain et al.

Summary: The human corneal endothelium plays a crucial role in maintaining corneal hydration and transparency, but damage to these nonproliferating cells can lead to vision issues. Current standard surgeries involve endothelial keratoplasties, but there is a significant global shortage of corneal grafting tissue, highlighting the need for alternative solutions such as utilizing biomaterials.

THERAPEUTIC ADVANCES IN OPHTHALMOLOGY (2021)

Review Cell Biology

Retinal pigment epithelium polarity in health and blinding diseases

Paulo S. Caceres et al.

CURRENT OPINION IN CELL BIOLOGY (2020)

Review Ophthalmology

The cell biology of the retinal pigment epithelium

Aparna Lakkaraju et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2020)

Article Oncology

CD200 promotes immunosuppression in the pancreatic tumor microenvironment

Fouad Choueiry et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Medicine, General & Internal

HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration

Sunao Sugita et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

PACAP through EGFR transactivation preserves human corneal endothelial integrity

Grazia Maugeri et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Article Biotechnology & Applied Microbiology

Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration

Lyndon da Cruz et al.

NATURE BIOTECHNOLOGY (2018)

Article Medicine, General & Internal

Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy

Shigeru Kinoshita et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Ophthalmology

Generation and Proteome Profiling of PBMC-Originated, iPSC-Derived Corneal Endothelial Cells

Muhammad Ali et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

Article Cell & Tissue Engineering

Skin-Derived Precursors as a Source of Progenitors for Corneal Endothelial Regeneration

Emi Inagaki et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

Article Chemistry, Medicinal

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

Yangbo Feng et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Ophthalmology

Global Survey of Corneal Transplantation and Eye Banking

Philippe Gain et al.

JAMA OPHTHALMOLOGY (2016)

Article Ophthalmology

Clinical Trials in Retinal Dystrophies

Seanna R. Grob et al.

MIDDLE EAST AFRICAN JOURNAL OF OPHTHALMOLOGY (2016)

Article Ophthalmology

Generation of Human Corneal Endothelial Cells via In Vitro Ocular Lineage Restriction of Pluripotent Stem Cells

Jiagang J. Zhao et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)

Article Ophthalmology

Effect of the Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) on Corneal Endothelial Wound Healing

Naoki Okumura et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)

Article Ophthalmology

Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells

Lyndsay L. Leach et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Article Multidisciplinary Sciences

Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells

Julien Maruotti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Cell & Tissue Engineering

Stem cell-based therapy of corneal epithelial and endothelial diseases

Songtao Yuan et al.

REGENERATIVE MEDICINE (2015)

Article Ophthalmology

Stem cells as source for retinal pigment epithelium transplantation

Evelina Bertolotti et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2014)

Article Ophthalmology

Cell Surface Markers of Functional Phenotypic Corneal Endothelial Cells

Naoki Okumura et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)

Article Cell & Tissue Engineering

Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway

Kana Hirata-Tominaga et al.

STEM CELLS (2013)

Article Cell & Tissue Engineering

Rapid and Efficient Directed Differentiation of Human Pluripotent Stem Cells Into Retinal Pigmented Epithelium

David E. Buchholz et al.

STEM CELLS TRANSLATIONAL MEDICINE (2013)

Article Ophthalmology

Identification of Cell Surface Markers Glypican-4 and CD200 That Differentiate Human Corneal Endothelium From Stromal Fibroblasts

Yuen Kuen Cheong et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)

Article Ophthalmology

Proliferative capacity of corneal endothelial cells

Nancy C. Joyce

EXPERIMENTAL EYE RESEARCH (2012)

Article Multidisciplinary Sciences

Cell Pattern in Adult Human Corneal Endothelium

Carlos H. Woerner et al.

PLOS ONE (2011)

Article Medicine, Research & Experimental

The Retinal Pigment Epithelium in Health and Disease

J. R. Sparrrow et al.

CURRENT MOLECULAR MEDICINE (2010)

Review Ophthalmology

Dynamic Regulation of Barrier Integrity of the Corneal Endothelium

Sangly P. Srinivas

OPTOMETRY AND VISION SCIENCE (2010)

Article Developmental Biology

Neural crest derivatives in ocular and periocular structures

S Creuzet et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2005)

Article Ophthalmology

Regional differences and post-mortem stability of enzymatic activities in the retinal pigment epithelium

E Fröhlich et al.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2003)

Article Ophthalmology

Growth of cultured porcine retinal pigment epithelial cells

AK Wiencke et al.

ACTA OPHTHALMOLOGICA SCANDINAVICA (2003)

Review Ophthalmology

Identity and regulation of ion transport mechanisms in the corneal endothelium

JA Bonanno

PROGRESS IN RETINAL AND EYE RESEARCH (2003)