CSF, Blood, and MRI Biomarkers in Skogholt's Disease-A Rare Neurodegenerative Disease in a Norwegian Kindred

Article Multidisciplinary Sciences

Segmenting white matter hyperintensities on isotropic three-dimensional Fluid Attenuated Inversion Recovery magnetic resonance images: Assessing deep learning tools on a Norwegian imaging database

Martin Soria Rovang et al.

Summary: Deep learning tools based on 3D FLAIR-weighted images can achieve automated segmentation and characterization of WMH, outperforming 2.5D models and SOTA deep Bayesian networks in performance.

PLOS ONE (2023)

Add to Collection

Article Medical Laboratory Technology

Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid

Johan Gobom et al.

Summary: The study evaluated the LUMIPULSE G assays for core cerebrospinal fluid biomarkers and established cutpoints for Alzheimer's disease diagnosis. Results showed strong correlation and reliable analytical performance of the LUMIPULSE G assays.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Add to Collection

Editorial Material Cell Biology

Ferroptosis: copper-iron connection in cuprizone-induced demyelination

Priya Jhelum et al.

NEURAL REGENERATION RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Skogholt's disease-A tauopathy precipitated by iron and copper?

Klaus T. Aspli et al.

Summary: Skogholt's disease is a new neurological disorder that affects the brain and peripheral nerves. The disease is characterized by high levels of copper and iron in the cerebrospinal fluid, which may contribute to inflammation in the central nervous system. Cognitive assessments showed that patients performed below normal range, suggesting a possible association with tauopathies, a family of neurodegenerative disorders.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2022)

Add to Collection

Article Neurosciences

FastSurferVINN: Building resolution-independence into deep learning segmentation methods-A solution for HighRes brain MRI

Leonie Henschel et al.

Summary: This study fills the gap in existing methods in the field of high-resolution MRI (HiRes) by proposing a Voxel-size Independent Neural Network (VINN) for resolution-independent image segmentation tasks. The FastSurferVINN method achieves whole brain segmentation within the resolution range of 0.7-1.0 mm and significantly outperforms existing methods at various resolutions. Additionally, this method addresses the data imbalance problem in HiRes datasets and has important application prospects.

NEUROIMAGE (2022)

Add to Collection

Article Clinical Neurology

Measurement of prothrombin fragment 1+2 in cerebrospinal fluid to identify thrombin generation in inflammatory central nervous system diseases

Jan Hendrik Schaefer et al.

Summary: This study found a strong correlation between PF1.2 and fibrinogen as well as PF1.2 and D-dimer in the cerebrospinal fluid (CSF) of patients with autoimmune inflammatory CNS diseases, indicating activation of the coagulation system. The findings suggest that thrombin generation might require acute blood-brain barrier dysfunction to exert autoimmune effects in the CNS.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Add to Collection

Article Neurosciences

Comparison of structural MRI brain measures between 1.5 and 3 T: Data from the Lothian Birth Cohort 1936

Colin R. Buchanan et al.

Summary: The study found differences in MRI measurements between different scanners, but good consistency. Between-scanner consistency was good to excellent for global volumes and some brain regions, fair for white matter tracts and cortical surface measures, and improved for whole-brain networks. While individual network connections showed poor consistency, overall global metrics showed good to excellent consistency after adjustments.

HUMAN BRAIN MAPPING (2021)

Add to Collection

Article Clinical Neurology

Baseline Blood-Brain Barrier Leakage and Longitudinal Microstructural Tissue Damage in the Periphery of White Matter Hyperintensities

Danielle Kerkhofs et al.

Summary: The 2-year change in parenchymal diffusivity in patients with cerebral small vessel disease is related to baseline blood-brain barrier permeability in the perilesional zone of white matter hyperintensities. This suggests that blood-brain barrier impairment may contribute to microstructural white matter degeneration in cSVD.

NEUROLOGY (2021)

Add to Collection

Editorial Material Clinical Neurology

Glial fibrillary acidic protein: a blood biomarker to differentiate neurodegenerative from psychiatric diseases

Henrik Zetterberg

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

Add to Collection

Review Neurosciences

Blood-cerebrospinal fluid (CSF) barrier dysfunction means reduced CSF flow not barrier leakage - conclusions from CSF protein data

Hansotto Reiber

Summary: Blood-CSF and blood-brain barrier dysfunctions are indications of reduced CSF or ISF flow rate. Serum protein concentrations in lumbar CSF increase with hyperbolic functions, while the levels of proteins that do not pass the barrier remain constant or increase linearly. Nonlinear changes support the diffusion/flow model in both normal and abnormal CSF flow, contradicting obstructions of diffusion pathways.

ARQUIVOS DE NEURO-PSIQUIATRIA (2021)

Add to Collection

Article Neurosciences