4.5 Article

The Genetic Basis of Probable REM Sleep Behavior Disorder in Parkinson's Disease

Related references

Note: Only part of the references are listed.
Article Neurosciences

Circadian expression and specific localization of synaptotagmin17 in the suprachiasmatic nucleus, the master circadian oscillator in mammals

Atsuko Fujioka et al.

Summary: This study investigated the localization and function of synaptotagmin 17 in the suprachiasmatic nucleus, and found that it is involved in regulating circadian rhythms.

BRAIN RESEARCH (2023)

Article Geriatrics & Gerontology

NPC1 variants are not associated with Parkinson's disease, REM-sleep behavior disorder or dementia with Lewy bodies in European cohorts

Emma N. Somerville et al.

Summary: NPC1 gene encodes a lysosomal protein involved in cholesterol transport associated with Niemann-Pick disease type C (NPC). The role of NPC1 in alpha synucleinopathies is unclear. This study aimed to evaluate the association of NPC1 variants with synucleinopathies PD, DLB, and RBD. No variants were associated with any of the synucleinopathies, indicating that NPC1 variants do not play an important role.

NEUROBIOLOGY OF AGING (2023)

Review Clinical Neurology

GBA-associated PD: chances and obstacles for targeted treatment strategies

Gunter Hoeglinger et al.

Summary: This review provides an overview of GBA-associated Parkinson's disease, focusing on clinical trajectories, pathological mechanisms, and treatment options. The severity of mutations influences disease characteristics, and these findings will guide patient stratification and clinical trial design in the future.

JOURNAL OF NEURAL TRANSMISSION (2022)

Article Multidisciplinary Sciences

Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

Lynne Krohn et al.

Summary: The study identifies five RBD risk loci and highlights the differential expression of SNCA-AS1 and SCARB2 genes in different brain regions. These findings provide further insights into the genetics of RBD and its potential for early intervention.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep

Daisuke Tone et al.

Summary: This study reveals the important role of CaMKII beta kinase in sleep regulation. Activation or inhibition of this kinase can increase or decrease the duration of sleep in mice. Furthermore, the phosphorylation states of CaMKII beta differently control sleep induction and maintenance processes.

PLOS BIOLOGY (2022)

Article Clinical Neurology

Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder

Kheireddin Mufti et al.

Summary: Rare coding variants in BST1 and rare noncoding variants in LAMP3 are associated with iRBD. Further studies are needed to confirm these findings and explore the potential of targeting BST1 loss of function as a therapeutic approach.

NEUROLOGY (2021)

Article Clinical Neurology

Association of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients

Aleksandra A. Szwedo et al.

Summary: The study showed that the rs356219 variant of SNCA may have a minor impact on modifying disease progression in patients with Parkinson's disease, while other SNCA variants were not significantly associated with differences in disease progression.

FRONTIERS IN NEUROLOGY (2021)

Article Clinical Neurology

Probable REM Sleep Behavior Disorder Is a Risk Factor for Symptom Progression in Parkinson Disease

Ashley Barasa et al.

Summary: The study found that probable RBD in PD patients predicts faster disease progression compared to controls, suggesting that detecting pRBD at the start could help identify fast progressors in clinical trials for potential disease-modifying treatments.

FRONTIERS IN NEUROLOGY (2021)

Review Clinical Neurology

LRRK2 in Parkinson disease: challenges of clinical trials

Eduardo Tolosa et al.

NATURE REVIEWS NEUROLOGY (2020)

Article Clinical Neurology

Association between ZNF184 and symptoms of Parkinson's disease in southern Chinese

Bei Zhang et al.

NEUROLOGICAL SCIENCES (2020)

Article Geriatrics & Gerontology

SMPD1 variants do not have a major role in rapid eye movement sleep behavior disorder

Uladzislau Rudakou et al.

NEUROBIOLOGY OF AGING (2020)

Article Clinical Neurology

GBA variants in REM sleep behavior disorder A multicenter study

Lynne Krohn et al.

NEUROLOGY (2020)

Review Neurosciences

REM sleep behavior disorder (RBD)

Michele T. Hu

NEUROBIOLOGY OF DISEASE (2020)

Article Multidisciplinary Sciences

REM sleep behavior in Parkinson disease: Frequent, particularly with higher age

Heide Baumann-Vogel et al.

PLOS ONE (2020)

Article Neurosciences

Ankyrins: Roles in synaptic biology and pathology

Katharine R. Smith et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2018)

Article Clinical Neurology

Parkinson's disease phenotype is influenced by the severity of the mutations in the GBA gene

Avner Thaler et al.

PARKINSONISM & RELATED DISORDERS (2018)

Article Clinical Neurology

LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder

Bouchra Ouled Amar Bencheikh et al.

PARKINSONISM & RELATED DISORDERS (2018)

Review Clinical Neurology

REM sleep behavior disorder (RBD) Update on diagnosis and treatment

Birgit Hoegl et al.

SOMNOLOGIE (2017)

Editorial Material Clinical Neurology

ABSENCE OF LRRK2 MUTATIONS IN A COHORT OF PATIENTS WITH IDIOPATHIC REM SLEEP BEHAVIOR DISORDER

Ruben Fernandez-Santiago et al.

NEUROLOGY (2016)

Article Clinical Neurology

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease

Michal Rolinski et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2014)

Editorial Material Clinical Neurology

LESIONAL REM SLEEP BEHAVIOR DISORDER LOCALIZES TO THE DORSOMEDIAL PONS

Erik K. St Louis et al.

NEUROLOGY (2014)

Article Clinical Neurology

The timing between REM sleep behavior disorder and Parkinson's disease

Raffaele Ferri et al.

SLEEP AND BREATHING (2014)

Article Clinical Neurology

Parkinson's disease and REM sleep behavior disorder result in increased non-motor symptoms

Ariel B. Neikrug et al.

SLEEP MEDICINE (2014)

Article Medical Laboratory Technology

Understanding logistic regression analysis

Sandro Sperandei

BIOCHEMIA MEDICA (2014)

Article Clinical Neurology

Associations of Sleep Disturbance Symptoms With Health-Related Quality of Life in Parkinson's Disease

Alon Avidan et al.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2013)

Review Clinical Neurology

Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease

Bradley F. Boeve

LANCET NEUROLOGY (2013)

Review Clinical Neurology

REM Sleep Behavior Disorder and REM Sleep Without Atonia as an Early Manifestation of Degenerative Neurological Disease

Stuart J. McCarter et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2012)

Review Clinical Neurology

Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment

K. Ray Chaudhuri et al.

LANCET NEUROLOGY (2009)

Article Clinical Neurology

The REM sleep behavior disorder screening questionnaire -: A new diagnostic instrument

Karin Stiasny-Kolster et al.

MOVEMENT DISORDERS (2007)

Article Multidisciplinary Sciences

α-synuclein locus triplication causes Parkinson's disease

AB Singleton et al.

SCIENCE (2003)