Journal
NATURE MEDICINE
Volume 22, Issue 10, Pages 1090-1093Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4161
Keywords
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Funding
- Wellcome Trust [090170, 104803]
- Bill and Melinda Gates Foundation-Wellcome Trust Grand challenges in Global Health [37822]
- US National Institutes of Health (NIH) [R01 HL106804]
- intramural research program of the NIH-NIAID
- European Union [FP& HEALTH F3-2012-305578]
- National Research Foundation of South Africa [96841]
- Research Councils of the UK via the Francis Crick Institute [10218, U117565642]
- Medical Research Council of South Africa (Strategic Health Innovations partnership)
- MRC [MC_U117588499, MC_U117565642] Funding Source: UKRI
- Cancer Research UK
- The Francis Crick Institute [10126] Funding Source: researchfish
- Medical Research Council [MC_U117588499, 1105853, MC_U117565642, 1365570] Funding Source: researchfish
- The Francis Crick Institute [10218, 10222] Funding Source: researchfish
- Wellcome Trust [104803/Z/14/Z] Funding Source: researchfish
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Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
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