Journal
NATURE MEDICINE
Volume 22, Issue 11, Pages 1256-1259Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4193
Keywords
-
Funding
- University of Washington Department of Obstetrics and Gynecology
- US National Institutes of Health (NIH) [R01AI100989, AI104002, AI083019, R01EB017133, R01NS055064, R01NS061957]
- NIH [T32 HD007233, T32 AI07509]
- Office of Research Infrastructure Programs (ORIP) of the NIH [P51OD010425]
Ask authors/readers for more resources
We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
