Journal
NATURE MEDICINE
Volume 22, Issue 3, Pages 250-253Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4039
Keywords
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Funding
- CD Research Fund
- US National Institutes of Health [R01 DK090989]
- Crohn's and Colitis Foundation of America [362048]
- Sinai Ulcerative Colitis: Clinical, Experimental & Systems Studies philanthropic grant
- Laura and Isaac Perlmutter Cancer Center [P30CA016087]
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Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria which were underrepresented in unexposed C-section-delivered infants and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section-delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section-delivered babies.
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