☆ 4.6 Article

Carbapenem-Resistant Klebsiella pneumoniae in COVID-19 Era-Challenges and Solutions

ANTIBIOTICS-BASEL (2023)

Related references

Note: Only part of the references are listed.

Article Microbiology

Trends in carbapenem resistance in Pre-COVID and COVID times in a tertiary care hospital in North India

Nirupama Chatterjee et al.

Summary: In this study, the rates of carbapenem resistance and the prevalence of different carbapenemases in different bacteria were investigated in a north-Indian tertiary care hospital. The study compared the Pre-COVID period (August to October 2019) with the COVID period (January to February 2021). It was found that the overall carbapenem resistance rate increased from 23% to 41% during the COVID period, with Pseudomonas aeruginosa and Klebsiella pneumoniae showing significant increase. The most common genotypes detected were OXA-48, NDM, and co-expression of NDM and OXA-48.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2023)

Add to Collection

Review Infectious Diseases

Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

Theodoros Karampatakis et al.

Summary: Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for various infections. Carbapenem-resistant K. pneumoniae (CRKP) pose a major threat to public health, with high mortality rates in immunocompromised and critically ill patients. Understanding the virulence factors, molecular epidemiology, and treatment options for CRKP is crucial.

ANTIBIOTICS-BASEL (2023)

Add to Collection

Article Medicine, General & Internal

Clinical characteristics of carbapenem-resistant Klebsiella pneumoniae infection/colonisation in the intensive care unit: a 9-year retrospective study

Fei Wang et al.

Summary: This retrospective single-center study investigated the epidemiology and extent of carbapenem-resistant Klebsiella pneumoniae (CRKP) infection/colonization in the intensive care unit (ICU), as well as the sources and risk factors for CRKP. The rate of CRKP increased over time and the severity of resistance also increased. Intensive and local infection/colonization control measures are necessary for ICU patients, especially those with risk factors for CRKP.

BMJ OPEN (2023)

Add to Collection

Article Microbiology

Worldwide transmission of ST11-KL64 carbapenem-resistant Klebsiella pneumoniae: an analysis of publicly available genomes

Junna Wang et al.

Summary: This study investigated the transmission of ST11-KL64 strains based on genome sequencing and identified international and interprovincial transmission of these strains in China. The use of dynamic grouping in addition to static clustering provided higher resolution and increased confidence in determining transmission. These findings highlight the importance of coordinated actions to tackle multi-drug resistant organisms.

MSPHERE (2023)

Add to Collection

Article Infectious Diseases

Epidemiological Characteristics and Antimicrobial Resistance Changes of Carbapenem-Resistant Klebsiella pneumoniae and Acinetobacter baumannii under the COVID-19 Outbreak: An Interrupted Time Series Analysis in a Large Teaching Hospital

Xinyi Yang et al.

Summary: To investigate the impact of the COVID-19 pandemic on carbapenem-resistant organisms (CROs), the epidemiological characteristics and resistance changes of CROs were analyzed. The study found that the resistance rate of carbapenem-resistant Acinetobacter baumannii (CRAB) increased significantly after the COVID-19 outbreak, while the resistance rate of Klebsiella pneumoniae remained stable. Stratified analysis revealed that factors such as gender, age, sample type, and clinical department contributed to the resistance rate of Klebsiella pneumoniae. This highlights the importance of closely monitoring CROs, especially in high-risk populations and clinical departments, during the COVID-19 pandemic.

ANTIBIOTICS-BASEL (2023)

Add to Collection

Review Virology

Phage therapy for secondary bacterial infections with COVID-19

Nannan Wu et al.

Summary: With over 200 million people affected and 4.5 million dead, the COVID-19 pandemic has become one of the greatest disasters in human history. Secondary bacterial infections (SBIs) are known complications of viral respiratory infections, and antibiotic treatments often fail to cure the patients. Phages, as natural killers of bacteria, are considered promising alternatives to antibiotics for treating pulmonary bacterial infections. However, their use for treating SBIs during virus pandemics like COVID-19 is still not well understood.

CURRENT OPINION IN VIROLOGY (2022)

Add to Collection

Article Infectious Diseases

Prevalence of Carbapenem-Resistant Klebsiela pneumoniae Infection in a Northern Province in China: Clinical Characteristics, Drug Resistance, and Geographic Distribution

Na Wang et al.

Summary: This study analyzed the clinical distribution and drug resistance of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains in Hebei Province, China. The findings showed a high and increasing resistance rate to most antibiotics, with CRKP mainly causing lung infection in elderly men.

INFECTION AND DRUG RESISTANCE (2022)

Add to Collection

Article Public, Environmental & Occupational Health

Carbapenem-resistant bacteria in an intensive care unit during the coronavirus disease 2019 (COVID-19) pandemic: A multicenter before-and-after cross-sectional study

Renato Pascale et al.

Summary: This study assessed the incidence of colonization and infection with CPE and CR-Ab in ICUs before and during the COVID-19 pandemic. The results showed no significant change in CPE colonization and infection, but a significant increase in CR-Ab colonization and infection. The CR-Ab strains belonged to the same clonal lineage and horizontal transmission was observed. Therefore, infection control activities should be conducted during the pandemic and adjusted according to the situation.

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY (2022)

Add to Collection

Review Immunology

Global Threat of Carbapenem-Resistant Gram-Negative Bacteria

Shio-Shin Jean et al.

Summary: Infections caused by multidrug-resistant Gram-negative bacteria have become a major challenge to public health. Hospitals and healthcare institutions face significant economic burden in controlling the spread of these bacteria. Some antibiotics have shown effectiveness against these resistant strains.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Add to Collection

Article Infectious Diseases

Carbapenemase-producing Enterobacterales infections in COVID-19 patients

Vicente Pintado et al.

Summary: Patients with COVID-19 have an increased risk of CPE infections, which often present as severe, nosocomial infections in critically-ill patients and are associated with a higher mortality rate.

INFECTIOUS DISEASES (2022)

Add to Collection

Article Virology

Bacteriophage Cocktails in the Post-COVID Rehabilitation

Fedor M. M. Zurabov et al.

Summary: Increasing evidence suggests that gut dysbiosis is associated with COVID-19 infection and may persist long after disease resolution. Excessive use of antimicrobials in COVID-19 patients can lead to further destruction of the microbiota and antimicrobial resistance. Bacteriophages are promising candidates for regulating the microbiota in the human body.

VIRUSES-BASEL (2022)

Add to Collection

Article Infectious Diseases

Antibiotic Resistance, Molecular Characteristics and Risk Factors of Carbapenem-Resistant Klebsiella pneumoniae in Clinical Isolates

Jingxuan Zhu et al.

Summary: This study investigated the antibiotic resistance and molecular characteristics of CRKP strains isolated in Zhejiang Province, China, revealing that CRKP isolates in ICU showed significantly higher resistance rates than those in general ward patients, 50 strains carried the blaKPC gene, and pulmonary disease may affect the prognosis of CRKP infection.

INFECTION AND DRUG RESISTANCE (2022)

Add to Collection

Article Infectious Diseases

Emergence of Ceftazidime-Avibactam Resistance and Decreased Virulence in Carbapenem-Resistant ST11 Klebsiella pneumoniae During Antibiotics Treatment

Mengxin Xu et al.

Summary: This study reports for the first time the development of CZA resistance and decreased virulence in ST11 CRKP strains during antimicrobial treatment. The findings emphasize the urgency to monitor CZA resistance and adjust anti-infective treatment strategies in a timely manner.

INFECTION AND DRUG RESISTANCE (2022)

Add to Collection

Article Infectious Diseases

Next-Generation Sequencing of Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated from Patients Hospitalized in the University Hospital Facilities

Jan Koren et al.

Summary: Carbapenem-resistant Klebsiella pneumoniae is a serious threat in university hospitals, with different sequence types associated with intra-hospital and inter-hospital transmission. These strains exhibit high levels of antibiotic resistance. Preventing the spread of these pathogens between healthcare facilities is crucial.

ANTIBIOTICS-BASEL (2022)

Add to Collection

Article Biology

Clinical evolution of ST11 carbapenem resistant and hypervirulent Klebsiella pneumoniae

Miaomiao Xie et al.

Summary: This study revealed that carbapenem-resistant and hypervirulent Klebsiella pneumoniae strains carry phenotypes on a plasmid formed from the fusion of a virulence plasmid with a conjugative plasmid, causing infections with extremely high mortality rates in various countries. The conjugative plasmid identified in a clinical CR-HvKP strain enables rapid expression of carbapenem resistance and hypervirulence phenotypes in other strains upon transfer.

COMMUNICATIONS BIOLOGY (2021)

Add to Collection

Article Microbiology

Colistin resistance in Gram-negative bacteria analysed by five phenotypic assays and inference of the underlying genomic mechanisms

Diana Albertos Torres et al.

Summary: Colistin is used to combat multi-drug resistant pathogens, with resistance emerging either through plasmid-mediated genes or chromosomal mutations. This study compared the performance of five phenotypic approaches in detecting colistin resistance mechanisms. The Rapid Polymyxin (TM) NP test showed highest categorical concordance, while UMIC provided MIC values that closely matched with the standard BMD method. Colistin resistance was found to occur predominantly through chromosomal mutations rather than plasmid-mediated mechanisms across diverse species.

BMC MICROBIOLOGY (2021)

Add to Collection

Letter Infectious Diseases

Klebsiella pneumoniae infections in COVID-19 patients: a 2-month retrospective analysis in an Italian hospital

Gabriele Arcari et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

Add to Collection

Review Infectious Diseases

Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales

Xing Tan et al.

Summary: This review outlines recent advancements in diagnostic and treatment strategies for infections caused by MBL-producing Enterobacterales, emphasizing the importance of detecting beta-lactamase in the clinic and current molecular platforms available for identifying MBLs. The review also discusses the potential use of antibiotics like ceftazidime-avibactam and cefiderocol for treating infections caused by MBL-producing Enterobacterales, as well as promising MBL inhibitors in development to improve treatment outcomes.

INFECTION AND DRUG RESISTANCE (2021)

Add to Collection

Editorial Material Public, Environmental & Occupational Health

Impact of SARS CoV-2 pandemic on carbapenemase-producing Klebsiella pneumoniae prevention and control programme: convergent or divergent action?

V. Belvisi et al.

JOURNAL OF HOSPITAL INFECTION (2021)

Add to Collection

Article Infectious Diseases

Multidrug-Resistant Infections and Outcome of Critically Ill Patients with Coronavirus Disease 2019: A Single Center Experience

Arta Karruli et al.

Summary: This study found that in COVID-19 patients, those who stayed longer in the ICU and received steroid therapy were more susceptible to developing multidrug-resistant infections, but these infections did not result in worse outcomes.

MICROBIAL DRUG RESISTANCE (2021)

Add to Collection

Review Medicine, General & Internal

Carbapenem-Resistant Klebsiella pneumoniae Infections in ICU COVID-19 Patients-A Scoping Review

Wioletta Medrzycka-Dabrowska et al.

Summary: The study highlights the importance of paying attention to carbapenem-resistant Klebsiella pneumoniae infections in patients with COVID-19. Rational antibiotic therapy should be used to prevent the increase of bacterial resistance, along with continuous monitoring and surveillance of hospital infections caused by multidrug-resistant organisms.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Article Infectious Diseases

Carbapenem-Resistant Klebsiella pneumoniae Associated with COVID-19

Irina Magdalena Dumitru et al.

Summary: Infections with carbapenem-resistant Enterobacteriaceae pose a significant challenge in healthcare settings, especially with CRKP being resistant to the majority of available antimicrobial agents and leading to high rates of morbidity and mortality. A recent report of patients in an ICU with COVID-19 who developed invasive infections due to CP-Kp strains highlights the importance of rigorous antibiotic administration programs in intensive care units, especially for high-risk populations like the elderly.

ANTIBIOTICS-BASEL (2021)

Add to Collection

Article Microbiology

Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study

Mustafa Karatas et al.

Summary: The study aimed to evaluate the epidemiology and antimicrobial resistance patterns of bacterial pathogens in COVID-19 patients and compared them with control groups from pre-pandemic and pandemic era. The results showed a lower frequency of secondary bacterial infections in COVID-19 patients, indicating a need for more careful and targeted antimicrobial prescription. Additionally, there were differences in the etiology and antimicrobial resistance patterns of bacterial infections in COVID-19 patients compared to pre-pandemic and pandemic era control groups.

ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS (2021)

Add to Collection

Article Infectious Diseases

The Impact of COVID-19 on the Profile of Hospital-Acquired Infections in Adult Intensive Care Units

Aleksa Despotovic et al.

Summary: Hospital-acquired infections (HAIs) continue to be a global public health concern, especially with the ongoing COVID-19 pandemic. The study revealed high rates of antimicrobial resistance, particularly in COVID-19 patients, with Acinetobacter spp. being a dominant cause of HAIs. Urgent approval of new drugs and rigorous surveillance are needed to address the alarming resistance rates.

ANTIBIOTICS-BASEL (2021)

Add to Collection

Review Infectious Diseases

The Revival of Aztreonam in Combination with Avibactam against Metallo-β-Lactamase-Producing Gram-Negatives: A Systematic Review of In Vitro Studies and Clinical Cases

Carola Mauri et al.

Summary: The combination of aztreonam + avibactam shows promise in treating infections caused by MBL-producing bacteria, especially Enterobacterales. Clinical resolution within 30 days was reported in 80% of infected patients, with a lower success rate for patients with bloodstream infections caused by Pseudomonas. Further research is needed to fully understand the effectiveness of this combination therapy.

ANTIBIOTICS-BASEL (2021)

Add to Collection

Article Immunology

Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin

Xi Jin et al.

Summary: This study reported a case of hv-CRKP-associated infection and revealed the in-host evolution of resistance to tigecycline and polymyxin during clinical therapy. The results suggest that the hypervirulent ST11-KL64 clone poses a potential threat to anti-infection treatment with rapid and diverse evolution of resistance.

EMERGING MICROBES & INFECTIONS (2021)

Add to Collection

Editorial Material Pharmacology & Pharmacy

What are the treatment options for resistantKlebsiella pneumoniaecarbapenemase (KPC)-producing bacteria?

Martina Spaziante et al.

EXPERT OPINION ON PHARMACOTHERAPY (2020)

Add to Collection

Article Infectious Diseases

Clinical and Economic Burden of Carbapenem-Resistant Infection or Colonization Caused byKlebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter baumannii: A Multicenter Study in China

Xuemei Zhen et al.

ANTIBIOTICS-BASEL (2020)

Add to Collection

Article Medicine, General & Internal

Antimicrobial Stewardship Program, COVID-19, and Infection Control: Spread of Carbapenem-Resistant Klebsiella Pneumoniae Colonization in ICU COVID-19 Patients. What Did Not Work?

Beatrice Tiri et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection

Article Genetics & Heredity

A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition

Stefan E. Heiden et al.

GENOME MEDICINE (2020)

Add to Collection

Review Infectious Diseases

Virulence evolution, molecular mechanisms of resistance and prevalence of ST11 carbapenem-resistant Klebsiella pneumoniae in China: A review over the last 10 years

Wenjian Liao et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

Add to Collection

Article Infectious Diseases

Carbapenem-resistant Klebsiella pneumoniae in ICU-admitted COVID-19 patients: Keep an eye on the ball

G. Montrucchio et al.

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2020)

Add to Collection

Review Public, Environmental & Occupational Health

Burden of carbapenem non-susceptible infections in high-risk patients: systematic literature review and meta-analysis

Esther E. Avendano et al.

ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL (2020)

Add to Collection

Review Multidisciplinary Sciences

Impact of age, sex, comorbidities and clinical symptoms on the severity of COVID-19 cases: A meta-analysis with 55 studies and 10014 cases

Md. Abdul Barek et al.

HELIYON (2020)

Add to Collection

Review Immunology

Colistin and its role in the Era of antibiotic resistance: an extended review (2000-2019)

Mohamed Abd El-Gawad El-Sayed Ahmed et al.

EMERGING MICROBES & INFECTIONS (2020)

Add to Collection

Article Microbiology

Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread

Sophia David et al.

NATURE MICROBIOLOGY (2019)

Add to Collection

Review Infectious Diseases

Acinetobacter spp in a Third World Country with Socio-economic and Immigrants Challenges

Iman Dandachi et al.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2019)

Add to Collection

Article Immunology

Synergetic Effects of Combined Treatment of Colistin With Meropenem or Amikacin on Carbapenem-Resistant Klebsiella pneumoniae in vitro

Lan Yu et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Add to Collection

Review Microbiology

Treatment of Infections Caused by Extended-Spectrum-Beta-Lactamase-, AmpC-, and Carbapenemase-Producing Enterobacteriaceae

Jesus Rodriguez-Bano et al.

CLINICAL MICROBIOLOGY REVIEWS (2018)

Add to Collection

Article Infectious Diseases

Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial

Mical Paul et al.

LANCET INFECTIOUS DISEASES (2018)

Add to Collection

Article Medicine, General & Internal

High-dose tigecycline for the treatment of nosocomial carbapenem-resistant Klebsiella pneumoniae bloodstream infections A retrospective cohort study

Ting-Ting Geng et al.

MEDICINE (2018)

Add to Collection

Article Infectious Diseases

Risk Factors for Carbapenem-Resistant Klebsiella pneumoniae Infection: A Meta-Analysis

Pin Liu et al.

MICROBIAL DRUG RESISTANCE (2018)

Add to Collection

Review Oncology

Oropharyngeal colonization: epidemiology, treatment and ventilator-associated pneumonia prevention

Jonathan Messika et al.

ANNALS OF TRANSLATIONAL MEDICINE (2018)

Add to Collection

Article Immunology

Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients

Claire L. Gorrie et al.

CLINICAL INFECTIOUS DISEASES (2017)

Add to Collection

Article Microbiology

Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

Steven Marshall et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

Add to Collection

Article Microbiology

Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae

Catharine C. Bulik et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)

Add to Collection

Article Infectious Diseases

Evaluation of MIDITECH automated colorimetric MIC reading for antimicrobial susceptibility testing

R Gattringer et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.