Related references
Note: Only part of the references are listed.Kaempferol prevents the activation of complement C3 protein and the generation of reactive A1 astrocytes that mediate rat brain degeneration induced by 3-nitropropionic acid
Carmen Lopez-Sanchez et al.
FOOD AND CHEMICAL TOXICOLOGY (2022)
Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
A. Harrison Brody et al.
MOLECULAR NEURODEGENERATION (2022)
Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
Swapna Thomas et al.
MOLECULAR IMMUNOLOGY (2022)
Black Ginseng Ameliorates Cellular Senescence via p53-p21/p16 Pathway in Aged Mice
Su-Jeong Lee et al.
BIOLOGY-BASEL (2022)
Complement C1s as a diagnostic marker and therapeutic target: Progress and propective
Jun Ye et al.
FRONTIERS IN IMMUNOLOGY (2022)
Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice
Mickael Audrain et al.
ALZHEIMERS & DEMENTIA (2021)
Microglia Polarization from M1 toward M2 Phenotype Is Promoted by Astragalus Polysaccharides Mediated through Inhibition of miR-155 in Experimental Autoimmune Encephalomyelitis
Xiaojun Liu et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)
Challenges in the diagnosis of Parkinson's disease
Eduardo Tolosa et al.
LANCET NEUROLOGY (2021)
Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in aged mice
Lei Chen et al.
CNS NEUROSCIENCE & THERAPEUTICS (2021)
Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury
Stephanie S. Holden et al.
SCIENCE (2021)
The Role of Complement in Synaptic Pruning and Neurodegeneration
Angela Gomez-Arboledas et al.
IMMUNOTARGETS AND THERAPY (2021)
Salidroside Restores an Anti-inflammatory Endothelial Phenotype by Selectively Inhibiting Endothelial Complement After Oxidative Stress
Y. Wang et al.
INFLAMMATION (2020)
Structural characterization and anticomplement activities of three acidic homogeneous polysaccharides from Artemisia annua
Jiangyan Huo et al.
JOURNAL OF ETHNOPHARMACOLOGY (2020)
Immune cell regulation of glia during CNS injury and disease
Andrew D. Greenhalgh et al.
NATURE REVIEWS NEUROSCIENCE (2020)
Early Reactive A1 Astrocytes Induction by the Neurotoxin 3-Nitropropionic Acid in Rat Brain
Carmen Lopez-Sanchez et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Identification ofTYROBPandC1QBas Two Novel Key Genes With Prognostic Value in Gastric Cancer by Network Analysis
Junjie Jiang et al.
FRONTIERS IN ONCOLOGY (2020)
The good, the bad, and the opportunities of the complement system in neurodegenerative disease
Nicole D. Schartz et al.
JOURNAL OF NEUROINFLAMMATION (2020)
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Changjun Yin et al.
NATURE MEDICINE (2019)
L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice
Xin Zhou et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia
Michael J. Pontecorvo et al.
BRAIN (2019)
Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice
Rodney M. Ritzel et al.
NEUROBIOLOGY OF AGING (2019)
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Justin M. Long et al.
CELL (2019)
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau
Mickael Audrain et al.
MOLECULAR PSYCHIATRY (2019)
Parkinson's Disease and Parkinsonism
Michael T. Hayes
AMERICAN JOURNAL OF MEDICINE (2019)
Cigarette smoke induced reduction of C1q promotes emphysema
Xiaoyi Yuan et al.
JCI INSIGHT (2019)
Huntington's disease: a clinical review
P. McColgan et al.
EUROPEAN JOURNAL OF NEUROLOGY (2018)
Inhibition of Complement Drives Increase in Early Growth Response Proteins and Neuroprotection Mediated by Salidroside After Cerebral Ischemia
Wenfang Lai et al.
INFLAMMATION (2018)
New tricks for an ancient system: Physiological and pathological roles of complement in the CNS
Andrea J. Tenner et al.
MOLECULAR IMMUNOLOGY (2018)
Normal aging induces A1-like astrocyte reactivity
Laura E. Clarke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Local apoptotic-like mechanisms underlie complement mediated synaptic pruning
Balazs A. Gyorffy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement
Deniz Ugurlar et al.
SCIENCE (2018)
C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism
Guang Sheng Ling et al.
SCIENCE (2018)
Is the A-Chain the Engine That Drives the Diversity of C1q Functions? Revisiting Its Unique Structure
Berhane Ghebrehiwet et al.
FRONTIERS IN IMMUNOLOGY (2018)
Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits
Karen Krukowski et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies
Borislav Dejanovic et al.
NEURON (2018)
Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics
Matthew L. Pearn et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2017)
Immunomodulatory Role of Complement Proteins in the Neuropathology Associated with Opiate Abuse and HIV-1 Co-Morbidity
Supriya D. Mahajan et al.
IMMUNOLOGICAL INVESTIGATIONS (2017)
Salidroside Inhibits Inflammation Through PI3K/Akt/HIF Signaling After Focal Cerebral Ischemia in Rats
Yicong Wei et al.
INFLAMMATION (2017)
Nonclinical Development of ANX005: A Humanized Anti-C1q Antibody for Treatment of Autoimmune and Neurodegenerative Diseases
Janice A. Lansita et al.
INTERNATIONAL JOURNAL OF TOXICOLOGY (2017)
Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response
Qing Cai et al.
JOURNAL OF NEUROINFLAMMATION (2017)
Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain
Maria I. Fonseca et al.
JOURNAL OF NEUROINFLAMMATION (2017)
C1q as an autocrine and paracrine regulator of cellular functions
Berhane Ghebrehiwet et al.
MOLECULAR IMMUNOLOGY (2017)
Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow et al.
NATURE (2017)
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network
Hideyuki Takahashi et al.
ACTA NEUROPATHOLOGICA (2017)
Structure analysis of a heteropolysaccharide from Taraxacum mongolicum Hand.-Matz. and anticomplementary activity of its sulfated derivatives
MiaoMiao Chen et al.
CARBOHYDRATE POLYMERS (2016)
Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Hansen Lui et al.
CELL (2016)
The amyloid hypothesis of Alzheimer's disease at 25years
Dennis J. Selkoe et al.
EMBO MOLECULAR MEDICINE (2016)
Structure characterization of two novel polysaccharides isolated from the spikes of Prunella vulgaris and their anticomplement activities
Dongsheng Du et al.
JOURNAL OF ETHNOPHARMACOLOGY (2016)
Von Willebrand Factor Interacts with Surface-Bound C1q and Induces Platelet Rolling
Robert Kolm et al.
JOURNAL OF IMMUNOLOGY (2016)
Tanshinone IIA decreases the levels of inflammation induced by Aβ1-42 in brain tissues of Alzheimer's disease model rats
Bei-Ling Lu et al.
NEUROREPORT (2016)
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Soyon Hong et al.
SCIENCE (2016)
Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q
Kyoung Joo Cho et al.
SCIENTIFIC REPORTS (2016)
Marked variability in clinical presentation and outcome of patients with C1q immunodeficiency
Rosanne A. van Schaarenburg et al.
JOURNAL OF AUTOIMMUNITY (2015)
C1q, antibodies and anti-C1q autoantibodies
Frank J. Beurskens et al.
MOLECULAR IMMUNOLOGY (2015)
Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease
Sophia Carbutt et al.
NEUROSCIENCE LETTERS (2015)
Microglia: Dynamic Mediators of Synapse Development and Plasticity
Yuwen Wu et al.
TRENDS IN IMMUNOLOGY (2015)
The choreography of neuroinflammation in Huntington's disease
Andrea Crotti et al.
TRENDS IN IMMUNOLOGY (2015)
Relative Contribution of C1q and Aopototic Cell-Surface Calreticulin to Macrophage Phagocytosis
Melanie Verneret et al.
JOURNAL OF INNATE IMMUNITY (2014)
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
Yang Zhan et al.
NATURE NEUROSCIENCE (2014)
Complement activation in multiple sclerosis plaques: an immunohistochemical analysis
Gillian Ingram et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)
From development to dysfunction: Microglia and the complement cascade in CNS homeostasis
Matthew K. Zabel et al.
AGEING RESEARCH REVIEWS (2013)
C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity
Marie E. Benoit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
A Dramatic Increase of C1q Protein in the CNS during Normal Aging
Alexander H. Stephan et al.
JOURNAL OF NEUROSCIENCE (2013)
Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention
Alok Kumar et al.
BRAIN BEHAVIOR AND IMMUNITY (2012)
Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes
Atsuhiko T. Naito et al.
CELL (2012)
Anthocyanin-rich Acai (Euterpe oleracea Mart.) Fruit Pulp Fractions Attenuate Inflammatory Stress Signaling in Mouse Brain BV-2 Microglial Cells
Shibu M. Poulose et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)
Human and Pneumococcal Cell Surface Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Proteins Are Both Ligands of Human C1q Protein
Remi Terrasse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Dorothy P. Schafer et al.
NEURON (2012)
The human C1q globular domain: structure and recognition of non-immune self ligands
Christine Gaboriaud et al.
FRONTIERS IN IMMUNOLOGY (2012)
Heme Interacts with C1q and Inhibits the Classical Complement Pathway
Lubka T. Roumenina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Investigations on the C1q-Calreticulin-Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition
Helena Paidassi et al.
JOURNAL OF MOLECULAR BIOLOGY (2011)
Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease
Candan Depboylu et al.
JOURNAL OF NEUROIMMUNOLOGY (2011)
Possible Involvement of Complement Factor C1q in the Clearance of Extracellular Neuromelanin From the Substantia Nigra in Parkinson Disease
Candan Depboylu et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)
Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression
Marie E. Benoit et al.
JOURNAL OF NEUROSCIENCE (2011)
Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
Sarah J. Tabrizi et al.
LANCET NEUROLOGY (2011)
Astrocytes: biology and pathology
Michael V. Sofroniew et al.
ACTA NEUROPATHOLOGICA (2010)
Astrocyte heterogeneity: an underappreciated topic in neurobiology
Ye Zhang et al.
CURRENT OPINION IN NEUROBIOLOGY (2010)
The non-classical functions of the classical complement pathway recognition subcomponent C1q
Annapurna Nayak et al.
IMMUNOLOGY LETTERS (2010)
Cutting Edge: C1q Binds Deoxyribose and Heparan Sulfate through Neighboring Sites of Its Recognition Domain
Virginie Garlatti et al.
JOURNAL OF IMMUNOLOGY (2010)
C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production
Deborah A. Fraser et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Enhanced synaptic connectivity and epilepsy in C1q knockout mice
Yunxiang Chu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells
Deborah A. Fraser et al.
JOURNAL OF IMMUNOLOGY (2009)
Expression of complement system components during aging and amyloid deposition in APP transgenic mice
Julia Reichwald et al.
JOURNAL OF NEUROINFLAMMATION (2009)
Adiponectin binds C1q and activates the classical pathway of complement
Philip W. Peake et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide
Lubka T. Roumenina et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2008)
Antagonizing β-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum
Cora Sau-Wan Lai et al.
BRAIN RESEARCH (2008)
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition
Helena Paidassi et al.
JOURNAL OF IMMUNOLOGY (2008)
Complement component C1q inhibits β-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms
Karntipa Pisalyaput et al.
JOURNAL OF NEUROCHEMISTRY (2008)
The classical complement cascade mediates CNS synapse elimination
Beth Stevens et al.
CELL (2007)
Suppressive effects of melatonin on amyloid-β-induced glial activation in rat hippocampus
Yuxian Shen et al.
ARCHIVES OF MEDICAL RESEARCH (2007)
Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system
Tobias A. Rupprecht et al.
JOURNAL OF IMMUNOLOGY (2007)
Assembly of C1 and the MBL- and ficolin-MASP complexes: Structural insights
Christine Gaboriaud et al.
IMMUNOBIOLOGY (2007)
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
Stephen W. Scheff et al.
NEUROBIOLOGY OF AGING (2006)
Blood platelets activate the classical pathway of human complement
E. I. B. Peerschke et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2006)
Evidence that complement protein C1q interacts with c-reactive protein through its globular head region
Fabian D. G. McGrath et al.
JOURNAL OF IMMUNOLOGY (2006)
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
K Takahashi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction
MS Kojouharova et al.
JOURNAL OF IMMUNOLOGY (2004)
Complement Clq expression induced by Aβ in rat hippocampal organotypic slice cultures
R Fan et al.
EXPERIMENTAL NEUROLOGY (2004)
Structural and functional anatomy of the globular domain of complement protein C1q
W Kishore et al.
IMMUNOLOGY LETTERS (2004)
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
MI Fonseca et al.
JOURNAL OF NEUROSCIENCE (2004)
Microglial activation and increased synthesis of complement component C1q precedes blood-brain barrier dysfunction in rats
NJ Lynch et al.
MOLECULAR IMMUNOLOGY (2004)
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties
C Gaboriaud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains
U Kishore et al.
JOURNAL OF IMMUNOLOGY (2003)
Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
AJ Nauta et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Expression and function of C1q receptors and C1q binding proteins at the cell surface
I Ghiran et al.
IMMUNOBIOLOGY (2002)
CD14 expression by activated parenchymal microglia/macrophages and infiltrating monocytes following human traumatic brain injury
R Beschorner et al.
ACTA NEUROPATHOLOGICA (2002)
β-amyloid fibrils activate the C1 complex of complement under physiological conditions:: Evidence for a binding site for Aβ on the C1q globular regions
P Tacnet-Delorme et al.
JOURNAL OF IMMUNOLOGY (2001)
Complement activation in the human brain after traumatic head injury
BM Bellander et al.
JOURNAL OF NEUROTRAUMA (2001)
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
LF Lue et al.
GLIA (2001)
Advances in immunology: Complement (First of two parts).
MJ Walport
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Activated microglial cells and complement factors are unrelated to cortical Lewy bodies
AJM Rozemuller et al.
ACTA NEUROPATHOLOGICA (2000)
Expression of a complete and functional complement system by human neuronal cells in vitro
A Thomas et al.
INTERNATIONAL IMMUNOLOGY (2000)