Association between the peripheral neutrophil-to-lymphocyte ratio and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes

Article Gastroenterology & Hepatology

A multi-society Delphi consensus statement on new fatty liver disease nomenclature

Mary E. Rinella et al.

JOURNAL OF HEPATOLOGY (2023)

Article Gastroenterology & Hepatology

A prospective study on the prevalence of MASLD in people with type-2 diabetes in the community. Cost effectiveness of screening strategies

Roberta Forlano et al.

Summary: Screening for MASLD in the diabetic population in primary care is cost-effective, and traditional screening strategies underestimate the presence of significant liver disease in this setting.

LIVER INTERNATIONAL (2023)

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Review Cardiac & Cardiovascular Systems

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

Christoph Grander et al.

Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing due to global obesity epidemic. It is a systemic metabolic disease accompanied by insulin resistance and inflammation. While simple hepatic steatosis is the most common manifestation, around 10-20% of individuals with NAFLD have a more progressive disease course characterized by liver fibrosis and inflammation. NAFLD can progress to liver cirrhosis and hepatocellular carcinoma. Weight loss and lifestyle changes are the main treatments, and there are several promising medical treatment options currently under investigation.

CARDIOVASCULAR RESEARCH (2023)

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Review Endocrinology & Metabolism

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review

Wah-Kheong Chan et al.

Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the latest term for steatotic liver disease associated with metabolic syndrome. It is the most common cause of chronic liver disease and liver-related morbidity and mortality. In tackling the public health threat of obesity and obesity-related diseases, including MASLD, it is important for all stakeholders to be involved. Simple and clear assessment and referral pathways using non-invasive tests are crucial to identifying and referring patients with severe MASLD to specialist care, while managing patients with milder disease in primary care.

JOURNAL OF OBESITY & METABOLIC SYNDROME (2023)

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Review Medicine, General & Internal

Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes: Screening, Diagnosis, and Treatment

Stefano Ciardullo et al.

Summary: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic dysfunction-associated steatotic liver disease (MASLD), is common in patients with type 2 diabetes (T2D) and can lead to advanced liver fibrosis. Patients with T2D have an increased risk of liver-related complications and mortality. Screening for NAFLD/MASLD and advanced liver fibrosis is recommended in T2D patients. While there are no approved drugs for NAFLD/MASLD, certain antidiabetic drugs have shown positive effects on liver health. Diabetologists have the opportunity to actively treat NAFLD/MASLD and potentially change its natural course.

JOURNAL OF CLINICAL MEDICINE (2023)

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Review Gastroenterology & Hepatology

Women Have a Lower Risk of Nonalcoholic Fatty Liver Disease but a Higher Risk of Progression vs Men: A Systematic Review and Meta-analysis

Maya Balakrishnan et al.

Summary: In a systematic review and meta-analysis, it was found that women have a lower risk of NAFLD than men. However, once NAFLD is established, women have a higher risk of advanced fibrosis than men, especially after age 50 years.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Usefulness of neutrophil-to-lymphocyte ratio (NLR) as a prognostic predictor after treatment of hepatocellular carcinoma

Mohamad Mouchli et al.

Summary: The NLR has potential value in evaluating the prognosis of HCC patients in terms of survival, cancer recurrence, and graft survival, but there are differences in research results due to heterogeneity in study methods. Most studies indicate a correlation between high pre-treatment NLR levels and poor outcomes. NLR is a reliable and inexpensive biomarker that should be integrated into other prognostic models to guide outcomes following HCC treatment.

ANNALS OF HEPATOLOGY (2021)

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Review Biochemistry & Molecular Biology

Role of Insulin Resistance in MAFLD

Yoshitaka Sakurai et al.

Summary: Metabolic dysfunction is closely related to the development of non-alcoholic fatty liver disease (NAFLD), prompting consideration of renaming it as metabolic dysfunction-associated fatty liver disease (MAFLD). Factors such as obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome contribute to metabolic dysfunction, leading to insulin resistance and fat accumulation in the liver. Genetic factors also play a role in hepatic fat accumulation and fibrosis, exacerbating inflammation, fibrosis, and carcinogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Medicine, General & Internal

Inflammation and Fibrogenesis in MAFLD: Role of the Hepatic Immune System

Pietro Torre et al.

Summary: MAFLD is a newly proposed definition to better describe the spectrum of NAFLD, with progression driven by hepatic inflammation and fibrogenesis. Fibrosis is a dynamic process occurring in a microenvironment where it interacts with fibrogenic cells and elements including immune cells, yet there is currently no approved drug for treating this condition.

FRONTIERS IN MEDICINE (2021)

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Review Medicine, Research & Experimental

Non-alcoholic fatty liver disease: An overview of risk factors, pathophysiological mechanisms, diagnostic procedures, and therapeutic interventions

Samar H. Gerges et al.

Summary: NAFLD is a disorder characterized by excessive fat accumulation in the liver, which can progress to NASH, accompanied by inflammation and fibrosis. The pathophysiology of NAFLD and NASH involves a complex interplay between metabolic, environmental, and genetic factors. Currently, there is no FDA-approved treatment for NAFLD and NASH, with off-label medications and hepatoprotective agents being used instead.

LIFE SCIENCES (2021)

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Review Environmental Sciences

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Oriol Juanola et al.

Summary: NAFLD is a common cause of chronic liver disease in the Western world, often caused by factors such as obesity, metabolic diseases, and environmental agents. Progression from simple hepatic steatosis to NASH can lead to liver cirrhosis and complications. Understanding the mechanisms that cause this progression is crucial for controlling the advancement of the disease.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Review Endocrinology & Metabolism

Metabolic-associated fatty liver disease and lipoprotein metabolism

Joerg Heeren et al.

Summary: MAFLD is characterized by pathological accumulation of triglycerides in hepatocytes and is closely related to disturbances in systemic energy metabolism. Liver plays a central role in lipid metabolism, with excessive hepatic triglyceride synthesis being a key factor in the development of MAFLD. Interventions targeting lipid storage and energy combustion in adipose tissues may help ameliorate MAFLD.

MOLECULAR METABOLISM (2021)

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Article Medical Laboratory Technology

Distribution and reference interval establishment of neutral-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in Chinese healthy adults

Junjun Wang et al.

Summary: The study found that the reference interval for NLR, LMR, and PLR in Chinese healthy adults is influenced by gender and age, with the upper limits of NLR and PLR increasing with age in males but decreasing for LMR. In females, the reference upper limits showed fluctuations in different age groups, indicating a need for individualized assessment.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

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Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update

Annalisa Berzigotti et al.

Summary: The article provides the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for assessing liver disease severity and prognosis, with a focus on topics with relevant evidence published in the last 5 years.

JOURNAL OF HEPATOLOGY (2021)

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Article Medicine, General & Internal

Neutrophil to lymphocyte ratio (NLR) in COVID-19: A cheap prognostic marker in a resource constraint setting

Kaleem Ullah Toori et al.

Summary: In this study, 720 COVID-19 patients were analyzed to determine the association of neutrophil to lymphocyte ratio (NLR) with disease severity and mortality. The results showed a significant relationship between NLR and disease severity as well as mortality, suggesting NLR as a potential marker for assessing COVID-19 severity and predicting outcomes.

PAKISTAN JOURNAL OF MEDICAL SCIENCES (2021)

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Article Emergency Medicine

Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis

Zhiwei Huang et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Ze Chen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Gastroenterology & Hepatology

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

Mohammed Eslam et al.

JOURNAL OF HEPATOLOGY (2020)

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Editorial Material Gastroenterology & Hepatology

From NAFLD to MAFLD: when pathophysiology succeeds

Herbert Tilg et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Immunology

The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients

Ai-Ping Yang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Endocrinology & Metabolism

Imaging biomarkers of NAFLD, NASH, and fibrosis

Veeral Ajmera et al.

MOLECULAR METABOLISM (2020)

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Review Critical Care Medicine

Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis

Xiaoming Li et al.

CRITICAL CARE (2020)

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Article Nutrition & Dietetics

High Dose Pomegranate Extract Suppresses Neutrophil Myeloperoxidase and Induces Oxidative Stress in a Rat Model of Sepsis

Sanaz Tavasoli et al.

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (2019)

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Article Oncology

Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI)

Hiren Mandaliya et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2019)

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Article Medical Laboratory Technology

Normal Reference Intervals of Neutrophil-To-Lymphocyte Ratio, Platelet-To-Lymphocyte Ratio, Lymphocyte-To-Monocyte Ratio, and Systemic Immune Inflammation Index in Healthy Adults: a Large Multi-Center Study from Western China

Huaichao Luo et al.

CLINICAL LABORATORY (2019)

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Review Biochemistry & Molecular Biology

Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function

Yasuaki Aratani

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2018)

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Article Biochemistry & Molecular Biology

B2-Lymphocyte responses to oxidative stress-derived antigens contribute to the evolution of nonalcoholic fatty liver disease (NAFLD)

Stefania Bruzzi et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

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Article Gastroenterology & Hepatology

Optimal threshold of controlled attenuation parameter with MRI-PDFF as the gold standard for the detection of hepatic steatosis

Cyrielle Caussy et al.

HEPATOLOGY (2018)

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Article Cell Biology

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Patients with Sepsis: A Prospective Observational Study

Xuan Liu et al.

MEDIATORS OF INFLAMMATION (2016)

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Article Endocrinology & Metabolism

EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease

OBESITY FACTS (2016)

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Article Gastroenterology & Hepatology

Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity

Manoj Thapa et al.

HEPATOLOGY (2015)

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Article Immunology

Regulation of immune responses by neutrophils

Jing Wang et al.

YEAR IN IMMUNOLOGY: MYELOID CELLS AND INFLAMMATION (2014)

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Article Gastroenterology & Hepatology

Radiologic evaluation of nonalcoholic fatty liver disease

Seung Soo Lee et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Review Oncology

The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer

Graeme J. K. Guthrie et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2013)

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Article Gastroenterology & Hepatology

Predictive value of ALT levels for non-alcoholic steatohepatitis (NASH) and advanced fibrosis in non-alcoholic fatty liver disease (NAFLD)

Siddharth Verma et al.

LIVER INTERNATIONAL (2013)

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Article Pharmacology & Pharmacy

Alanine Aminotransferase: A Clinical and Regulatory Tool for Detecting Liver Injury-Past, Present, and Future

J. R. Senior

CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)

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Review Endocrinology & Metabolism

Lymphocytes in obesity-related adipose tissue inflammation

A. Chatzigeorgiou et al.

DIABETOLOGIA (2012)

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Article Biochemistry & Molecular Biology

Protective Role of Estrogen-induced miRNA-29 Expression in Carbon Tetrachloride-induced Mouse Liver Injury

Yaqin Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Review Biochemistry & Molecular Biology

The cellular and signaling networks linking the immune system and metabolism in disease

Olivia Osborn et al.

NATURE MEDICINE (2012)

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Review Nutrition & Dietetics

Nonalcoholic Fatty Liver Disease: A Review of the Spectrum of Disease, Diagnosis, and Therapy

Krzysztof Lukasz Kopec et al.

NUTRITION IN CLINICAL PRACTICE (2011)

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Article Cardiac & Cardiovascular Systems

Usefulness of Neutrophil to Lymphocyte Ratio in Predicting Short- and Long-Term Mortality After Non-ST-Elevation Myocardial Infarction

Basem Azab et al.

AMERICAN JOURNAL OF CARDIOLOGY (2010)

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Article Gastroenterology & Hepatology

Hepatic steatosis index: A simple screening tool reflecting nonalcoholic fatty liver disease

Jeong-Hoon Lee et al.

DIGESTIVE AND LIVER DISEASE (2010)

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Article Cardiac & Cardiovascular Systems

IL-8 and airway neutrophilia in children with gastroesophageal reflux and asthma-like symptoms

O Sacco et al.

RESPIRATORY MEDICINE (2006)

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Article Medicine, Research & Experimental

Attenuated liver fibrosis in the absence of B cells

TI Novobrantseva et al.

JOURNAL OF CLINICAL INVESTIGATION (2005)

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Association between the peripheral neutrophil-to-lymphocyte ratio and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes

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