Biologics targeting IL-17 and IL-23 maintain stability in patients with psoriasis during COVID-19 infection: a case-control study

Letter Dermatology

Impact of SARS-CoV-2 infection in children with psoriasis: Results of a monocentric experience

Francesca Caroppo et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

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Article Biology

Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months

Marianna Santopaolo et al.

eLife (2023)

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Article Immunology

Serum IL-23, IL-10, and TNF-α predict in-hospital mortality in COVID-19 patients

Shukur Wasman Smail et al.

Summary: This study aims to examine the relationship between serum inflammatory cytokines and the activation state of macrophages in COVID-19 patients, and to find accurate predictive markers for disease severity and mortality risk. The results showed that the levels of IL-10, IL-23, and TNF-alpha were significantly elevated in critical cases of COVID-19 patients and were associated with in-hospital mortality. Therefore, the detection and evaluation of these cytokines are important for assessing the prognosis of the disease.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Immunology

COVID-19 vaccination in psoriasis patients receiving systemic treatment: A prospective single-center study

Georg Christian Lodde et al.

Summary: This prospective single-center cohort study aimed to determine the rate of seroconversion after COVID-19 vaccination in patients under active systemic treatment for moderate to severe psoriasis. The results showed that 96.1% of patients undergoing systemic treatment for psoriasis achieved anti-SARS-CoV-2-S IgG seroconversion after COVID-19 vaccination, but impaired immune response was observed in patients receiving MTX and/or TNF-alpha inhibitors.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Multidisciplinary Sciences

The plasma metabolome of long COVID patients two years after infection

Yamilé López-Hernández et al.

Scientific Reports (2023)

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Article Immunology

Effect of antiviral and immunomodulatory treatment on a cytokine profile in patients with COVID-19

Diana Martonik et al.

Summary: This study analyzed the cytokine profile of COVID-19 patients undergoing antiviral and immunomodulatory treatment, and found that treatment can reduce the expression of inflammatory cytokines and increase T cell counts. Additionally, despite the decrease in CD4+ and CD8+ T cell counts, both subsets showed overactivation and increased expression of IL-17A and IL-22, suggesting that targeting the Th17 response may alleviate inflammatory response.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Dermatology

Real-world evidence of biologic treatments in moderate-severe psoriasis in Italy: Results of the CANOVA (EffeCtiveness of biologic treAtmeNts for plaque psOriasis in Italy: An obserVAtional longitudinal study of real-life clinical practice) study

Delia Colombo et al.

Summary: The study aimed to provide real-world evidence of the effectiveness of biologics in Italian patients with moderate-severe psoriasis. Results showed that biologics were effective and well tolerated in psoriasis patients, with a high percentage of patients achieving PASI 75 at 16-52 weeks of treatment and a high sustained response rate after 1 year.

DERMATOLOGIC THERAPY (2022)

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Review Biochemistry & Molecular Biology

Epigenetic Mechanisms of Epidermal Differentiation

Chiara Moltrasio et al.

Summary: Research has shown that the differentiation of keratinocytes is influenced by various transcription factors, signaling pathways, and epigenetic regulators, which promote differentiation by regulating chromatin modifications through activation and inhibition. Understanding the alterations in epigenetic mechanisms can facilitate their application in clinical practice, paving the way for promising therapeutic approaches.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Dermatology

National Psoriasis Foundation COVID-19 Task Force guidance for management of psoriatic disease during the pandemic: Version 2-Advances in psoriatic disease management, COVID-19 vaccines, and COVID-19 treatments

Joel M. Gelfand et al.

Summary: This study updated guidance for managing psoriatic disease during the COVID-19 pandemic, with 22 original statements and 5 new recommendations. Results showed high consensus for 13 statements and moderate consensus for 14 statements. However, there are limitations in the evidence behind the guidance statements, with variable quality and quantity.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Letter Dermatology

If skin is a potential host of SARS-CoV-2, IL-17 antibody could reduce the risk of COVID-19

Qiannan Xu et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

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Review Medicine, General & Internal

Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis

Kamran Ghoreschi et al.

Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.

LANCET (2021)

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Review Dermatology

Biologic Treatment Algorithms for Moderate-to-Severe Psoriasis with Comorbid Conditions and Special Populations: A Review

Akshitha Thatiparthi et al.

Summary: The emergence of biologics has increased therapeutic possibilities for psoriasis treatment, with data from clinical trials and studies providing essential information for personalized care. Treatment recommendations should consider comorbid conditions and special populations.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

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Article Medicine, General & Internal

Psoriasis

Christopher E M Griffiths et al.

LANCET (2021)

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Review Dermatology

COVID-19 and exacerbation of dermatological diseases: A review of the available literature

Khashayar Aram et al.

Summary: Concerns have been raised regarding exacerbation of underlying dermatological conditions in patients with chronic autoimmune diseases, including pemphigus vulgaris and psoriasis, following infection with SARS-CoV2 during the COVID-19 pandemic. Psoriasis and alopecia areata were the most commonly reported flare-ups, with psoriasis cases potentially linked to antimalarial treatment or discontinuation of therapy post COVID-19 infection.

DERMATOLOGIC THERAPY (2021)

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Review Dermatology