Related references
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Summary: We conducted a case-control study in 25 hospitals in India to investigate the causes of a COVID-19-associated mucormycosis outbreak. The study found that cumulative glucocorticoid dose, zinc supplementation, elevated C-reactive protein, host factors (renal transplantation, diabetes mellitus, diabetic ketoacidosis during COVID-19), and rural residence were significantly associated with CAM. The study emphasizes the importance of judicious use of COVID-19 therapies and optimal glycemic control to prevent CAM.
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Valliappan Muthu et al.
Summary: A consensus statement for the diagnosis and management of COVID-19-associated pulmonary mucormycosis (CAPM) was formulated using a modified Delphi method. Recommendations were proposed for defining, diagnosing, and managing CAPM, but further research is needed to fully understand this underdiagnosed entity.
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Valliappan Muthu et al.
Summary: The study aimed to assess the mortality and trend of pulmonary mucormycosis (PM) in immunocompromised patients. Results showed that mortality of PM has improved over time, with combined medical-surgical therapy associated with lower mortality risk than medical treatment alone. Risk of death was higher in disseminated disease compared to isolated PM, while diabetes mellitus was not associated with higher mortality risk.
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Valliappan Muthu et al.
Summary: The COVID-19 pandemic has led to a concerning resurgence of mucormycosis, with a high number of cases reported from India. Diabetes mellitus was the most common underlying risk factor for COVID-19-associated mucormycosis in India, where the fatality rate of reported cases was relatively lower compared to globally reported cases.
Article
Dermatology
Shivaprakash M. Rudramurthy et al.
Summary: Globally, the incidence of COVID-19-associated mucormycosis (CAM) is rising, with a significant surge in India. The need to address misconceptions in managing and treating this infection is crucial, with a focus on early suspicion, diagnosis confirmation, glycemic control, surgical debridement, and antifungal therapy. Limited availability of amphotericin B formulations during the epidemic has led to discussions on alternative antifungal therapies.
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Atul Patel et al.
Summary: This study found an increase in mucormycosis cases in India during the COVID-19 pandemic, mainly due to inappropriate glucocorticoid use, resulting in a higher mortality rate among mucormycosis patients.
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