Journal
NATURE IMMUNOLOGY
Volume 17, Issue 6, Pages 728-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3437
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Funding
- Alexander von Humboldt Foundation
- William K. Bowes Jr Foundation
- US National Institutes of Health [R01 HL114093, U19 AI100275, R37 AI71922, R01 AI105215]
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Natural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune response that can be attributed in part to the existence of functional subsets of NKT cells. These subsets have been characterized only on the basis of the differential expression of a few transcription factors and cell-surface molecules. Here we have analyzed purified populations of thymic NKT cell subsets at both the transcriptomic level and epigenomic level and by single-cell RNA sequencing. Our data indicated that despite their similar antigen specificity, the functional NKT cell subsets were highly divergent populations with many gene-expression and epigenetic differences. Therefore, the thymus 'imprints' distinct gene programs on subsets of innate-like NKT cells that probably impart differences in proliferative capacity, homing, and effector functions.
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