☆ 4.6 Article

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

METABOLITES (2023)

Related references

Note: Only part of the references are listed.

Article Microbiology

Genomic and Metabolite Profiling Reveal a Novel Streptomyces Strain, QHH-9511, from the Qinghai-Tibet Plateau

Xi-Long Feng et al.

Summary: Prevention and treatment of MRSA infections are crucial. This study identified a new Streptomyces species and used genome mining and metabolic analysis to determine the chemical origin of its antibacterial components. Various bioactive compounds with antimicrobial properties were also discovered.

MICROBIOLOGY SPECTRUM (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

Rubiflavin G, photorubiflavin G, and photorubiflavin E: Novel pluramycin derivatives from Streptomyces sp. W2061 and their anticancer activity against breast cancer cells

Byeongsan Lee et al.

Summary: The pluramycin family of antibiotics includes angucycline compounds derived from actinomycetes with anticancer and antibacterial properties. Pluramycins have a structural characteristic of two linked aminoglycosides on the γ-pyrone angucycline backbone. Kidamycins and rubiflavins were screened and characterized, and their cytotoxicity against breast cancer cell lines was evaluated. Photokidamycin showed significant inhibition of cell growth in both MCF7 and MDA-MB-231 cells.

JOURNAL OF ANTIBIOTICS (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

Taxonomy and anticancer potential of Streptomyces niphimycinicus sp. nov. against nasopharyngeal carcinoma cells

Yiying Huang et al.

Summary: Strain 4503(T) is a newly identified species of the genus Streptomyces, isolated from mangrove sediments, with the ability to produce clinically relevant compounds. Phylogenetic analysis based on 16S rRNA gene sequences revealed its close relationship to other Streptomyces species, but with distinct genetic and phenotypic characteristics.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2023)

Add to Collection

Article Microbiology

Identification of Antimicrobial Compounds in Two Streptomyces sp. Strains Isolated From Beehives

Fernando Santos-Beneit et al.

Summary: The World Health Organization warns of the increasing deaths caused by antibiotic resistant bacteria and emphasizes the need for short-term alternatives. Recent studies have found that honeybees and their products carry Streptomyces species with strong antibacterial activity. This study investigates the antibiotic profiles of two Streptomyces strains isolated from beehives and suggests their potential in discovering bioactive compounds with antimicrobial and anticancer properties.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection

Review Multidisciplinary Sciences

Early detection of cancer

David Crosby et al.

Summary: Early detection of cancer is crucial for improving survival rates, but unfortunately, a significant number of cases are diagnosed at an advanced stage. Overcoming various challenges is essential to achieve early detection for all cancers, including understanding high-risk individuals, elucidating the biology and trajectory of precancer and early cancer, and developing sensitive and specific detection technologies.

SCIENCE (2022)

Add to Collection

Article Oncology

Induction of apoptosis and cell cycle arrest in colorectal cancer cells by novel anticancer metabolites of Streptomyces sp. 801

Arghavan Kouroshnia et al.

Summary: This study demonstrates the promising anti-cancer activity of Streptomyces sp. 801 on colorectal cancer cells in vitro by inducing apoptosis, cell cycle arrest, and inhibiting cell migration. Nine anti-cancer compounds were identified from the strain, suggesting its potential as a source of anticancer metabolites.

CANCER CELL INTERNATIONAL (2022)

Add to Collection

Article Gastroenterology & Hepatology

Comparison of Clinical Outcomes of Borderline Resectable Pancreatic Cancer According to the Neoadjuvant Chemo-Regimens: Gemcitabine versus FOLFIRINOX

Yoo Jin Choi et al.

Summary: The study found that FOLFIRINOX provided more clinical and oncological benefit than gemcitabine in treating BRPC patients, including higher overall survival and lower recurrence rates. However, since FOLFIRINOX causes more adverse effects, the treatment regimen should be individualized based on the patient's general condition and clinical status.

GUT AND LIVER (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Genome mining for drug discovery: cyclic lipopeptides related to daptomycin

Richard H. Baltz

Summary: Cyclic lipopeptide antibiotics structurally related to daptomycin share common initiation, elongation, and termination mechanisms, allowing for the generation of a variety of compounds with different antibacterial mechanisms through target-agnostic resistance and combinatorial biosynthesis. Molecular beacons like FAAL, ACP, and dimodular NRPS genes have been used to identify phylogenetically related biosynthetic gene clusters in finished and draft genome sequences, leading to the discovery of new lipopeptide BGCs and a novel daptomycin family BGC.

JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2021)

Add to Collection

Article Microbiology

A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a Streptomyces Strain Collection Isolated from Leaf-Cutting Ants

Ana Ceniceros et al.

Summary: By analyzing the genomes of 12 Streptomyces sp. strains isolated from leaf-cutting ants of the Attini tribe, it was revealed that over half of the predicted biosynthetic gene clusters were strain-specific, indicating the potential for novel compound discovery in this strain collection.

MICROORGANISMS (2021)

Add to Collection

Review Oncology

Neoadjuvant therapy for pancreas cancer: Global perspective and optimal care pathways in low to middle-income countries

Senthil J. Rajappa et al.

Summary: Surgery is the only curative treatment for localized pancreatic adenocarcinoma, but delivering adjuvant chemotherapy can be suboptimal in some cases, leading to poor outcomes. Implementing standard neoadjuvant therapies in low to middle-income countries with limited resources may present challenges.

JOURNAL OF SURGICAL ONCOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The ecological roles of microbial lipopeptides: Where are we going?

Carolina Gutierrez-Chavez et al.

Summary: Lipopeptides (LPs) are secondary metabolites produced by various bacteria and fungi, with important biotechnological applications in emulsification, antitumor, immunomodulatory, and antimicrobial activities. Despite limited understanding of the ecological role of LPs, research on their mode of action in biofilm formation, antimicrobial activity, etc., can provide insights into their roles in the natural environment.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Add to Collection

Review Chemistry, Medicinal

Natural Products in Cancer Therapy: Past, Present and Future

Min Huang et al.

Summary: Natural products have been extensively studied for their anticancer potential for over half a century, leading to significant advancements in clinical use and therapeutic opportunities. However, challenges remain as the landscape of cancer therapy evolves and cutting-edge technologies play an increasing role. It is crucial to revisit and explore strategies for understanding and utilizing natural products in cancer therapy.

NATURAL PRODUCTS AND BIOPROSPECTING (2021)

Add to Collection

Article Biochemical Research Methods

Probing and Engineering the Fatty Acyl Substrate Selectivity of Starter Condensation Domains of Nonribosomal Peptide Synthetases in Lipopeptide Biosynthesis

Qian Liu et al.

BIOTECHNOLOGY JOURNAL (2020)

Add to Collection

Review Biotechnology & Applied Microbiology

Exploration and genome mining of natural products from marine Streptomyces

Zhijie Yang et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

On the possible ecological roles of antimicrobials

Gleb Pishchany et al.

MOLECULAR MICROBIOLOGY (2020)

Add to Collection

Article Microbiology

Functional Cross-Talk of MbtH-Like Proteins During Thaxtomin Biosynthesis in the Potato Common Scab Pathogen Streptomyces scabiei

Yuting Li et al.

FRONTIERS IN MICROBIOLOGY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Insights about clinically approved and Preclinically investigated marine natural products

Mosad A. Ghareeb et al.

CURRENT RESEARCH IN BIOTECHNOLOGY (2020)

Add to Collection

Review Microbiology

Cave Actinobacteria as Producers of Bioactive Metabolites

Pharada Rangseekaew et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

Kai Blin et al.

NUCLEIC ACIDS RESEARCH (2019)

Add to Collection

Article Multidisciplinary Sciences

TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy

Jan P. Meier-Kolthoff et al.

NATURE COMMUNICATIONS (2019)

Add to Collection

Article Biochemical Research Methods

Bacterial MbtH-like Proteins Stimulate Nonribosomal Peptide Synthetase-Derived Secondary Metabolism in Filamentous Fungi

Reto D. Zwahlen et al.

ACS SYNTHETIC BIOLOGY (2019)

Add to Collection

Review Microbiology

Diversity, Ecology, and Prevalence of Antimicrobials in Nature

Megan M. Mullis et al.

FRONTIERS IN MICROBIOLOGY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Piperazic acid-containing natural products: structures and biosynthesis

Kalindi D. Morgan et al.

NATURAL PRODUCT REPORTS (2019)

Add to Collection

Review Chemistry, Medicinal

Secondary Metabolites from Polar Organisms

Yuan Tian et al.

MARINE DRUGS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

Michael A. Skinnider et al.

NUCLEIC ACIDS RESEARCH (2017)

Add to Collection

Review Microbiology

Fungal and Bacterial Pigments: Secondary Metabolites with Wide Applications

Manik Prabhu Narsing Rao et al.

FRONTIERS IN MICROBIOLOGY (2017)

Add to Collection

Editorial Material Biotechnology & Applied Microbiology

Marine microbiome as source of natural products

Fernando de la Calle

MICROBIAL BIOTECHNOLOGY (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Pigments from UV-resistant Antarctic bacteria as photosensitizers in Dye Sensitized Solar Cells

N. Ordenes-Aenishanslins et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2016)

Add to Collection

Review Chemistry, Medicinal

Next Generation Sequencing of Actinobacteria for the Discovery of Novel Natural Products

Juan Pablo Gomez-Escribano et al.

MARINE DRUGS (2016)

Add to Collection

Article Biology

Antitumor compounds from Streptomyces sp KML-2, isolated from Khewra salt mines, Pakistan

Usman Aftab et al.

BIOLOGICAL RESEARCH (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

Peter Cimermancic et al.

CELL (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

Wanjuan Yang et al.

NUCLEIC ACIDS RESEARCH (2013)

Add to Collection

Editorial Material Biochemistry & Molecular Biology

Adding the Lipo to Lipopeptides: Do More with Less

Yit-Heng Chooi et al.

CHEMISTRY & BIOLOGY (2010)

Add to Collection

Article Cell Biology

Effect of themicrobial lipopeptide on tumor cell lines: apoptosis induced by disturbing the fatty acid composition of cell membrane

Xiangyang Liu et al.

PROTEIN & CELL (2010)

Add to Collection

Review Chemistry, Medicinal

Antitumor Compounds from Marine Actinomycetes

Carlos Olano et al.

MARINE DRUGS (2009)

Add to Collection

Article Evolutionary Biology

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

Christian Rausch et al.

BMC EVOLUTIONARY BIOLOGY (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line

Gitanjali M. Singh et al.

CHEMISTRY & BIOLOGY (2007)

Add to Collection

Article Oncology

The NCI60 human tumour cell line anticancer drug screen

Robert H. Shoemaker

NATURE REVIEWS CANCER (2006)

Add to Collection

Review Biology

Streptomyces inside-out: a new perspective on the bacteria that provide us with antibiotics

KF Chater

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2006)

Add to Collection

Review Microbiology

Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases

JE Clarridge

CLINICAL MICROBIOLOGY REVIEWS (2004)

Add to Collection

Article Microbiology

Rapid identification of filamentous actinomycetes to the genus level using genus-specific 16S rRNA gene restriction fragment patterns

AE Cook et al.

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.