Special Issue on Metabolic Adaptations in Cardiac and Skeletal Muscle during Acute and Chronic Exercise

Article Biochemistry & Molecular Biology

Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease

Jessica Lavier et al.

Summary: Exercise training is an important therapeutic strategy for treating lower extremity peripheral artery disease (PAD). This study aimed to compare the effects of exercising three or five times per week on skeletal muscle gene expression and physical performance in mice with PAD. The results showed that both exercise frequencies improved physical performance to the same extent, and there were no significant differences in gene expression patterns between the two groups. These findings suggest that exercising three to five times per week can have similar beneficial effects on performance in PAD mice.

METABOLITES (2023)

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Editorial Material Physiology

A century of exercise physiology: key concepts in ...

Michael Lindinger et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Can Exercise Training Alter Human Skeletal Muscle DNA Methylation?

Luis A. Garcia et al.

Summary: This study investigated the effect of exercise training on skeletal muscle DNA methylation in individuals with varying degrees of insulin sensitivity. The results showed that 8 weeks of training altered DNA methylation levels of specific genes and pathways.

METABOLITES (2022)

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Article Biochemistry & Molecular Biology

Effects of Moderate-Intensity Physical Training on Skeletal Muscle Substrate Transporters and Metabolic Parameters of Ovariectomized Rats

Taciane Maria Melges Pejon et al.

Summary: A deficit of estrogen is associated with energy substrate imbalance, raising the risk of metabolic diseases. This study found that physical training has positive effects on GLUT4 and FAT CD36 expression in the skeletal muscle of animals with estrogen deficit, as well as metabolic variables.

METABOLITES (2022)

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Article Biochemistry & Molecular Biology

The Effects of Exercise Training on Glucose Homeostasis and Muscle Metabolism in Type 1 Diabetic Female Mice

Caitlin C. O'Neill et al.

Summary: This study aimed to investigate the role of aerobic exercise training in T1D female mice and found that exercise training had limited effects on improving glucose homeostasis and muscle metabolism in T1D female mice, but did improve insulin sensitivity.

METABOLITES (2022)

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Article Biochemistry & Molecular Biology

Improved Peripheral and Hepatic Insulin Sensitivity after Lifestyle Interventions in Type 2 Diabetes Is Associated with Specific Metabolomic and Lipidomic Signatures in Skeletal Muscle and Plasma

Elin Chorell et al.

Summary: Lifestyle interventions such as weight loss, diet, and exercise can improve insulin sensitivity in patients with type 2 diabetes, reduce ectopic lipid deposits, and affect metabolite profiles in muscle and circulation; diet improved peripheral and hepatic insulin sensitivity, while the diet plus exercise group showed different changes in muscle metabolites.

METABOLITES (2021)

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Review Physiology

Exercise and health: historical perspectives and new insights

Mark Hargreaves

Summary: Research has shown that regular exercise is beneficial to health, particularly in the cardiovascular and skeletal muscle systems. The benefits of exercise are not only due to muscle contraction and communication between organs, but also involve other factors.

JOURNAL OF APPLIED PHYSIOLOGY (2021)

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Review Cell Biology

Skeletal Muscle Lipid Droplets and the Athlete's Paradox

Xuehan Li et al.

CELLS (2019)

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Review Biochemistry & Molecular Biology

Exercise and Gene Expression

Mark Hargreaves

MOLECULAR AND CELLULAR REGULATION OF ADAPTATION TO EXERCISE (2015)

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Special Issue on Metabolic Adaptations in Cardiac and Skeletal Muscle during Acute and Chronic Exercise

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