Journal
PATHOGENS
Volume 12, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/pathogens12070964
Keywords
immunity; mass spectrometry; proteomics; ADP-ribosylation; poly(ADP-ribose) glycohydrolase; Diphtheria toxin-like ADP-ribosyltransferases; chronic infection; arboviruses; cardiovascular disease; emphysema; alcoholic liver disease; SARS-CoV-2; host-pathogen interactions
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Aberrant adenosine diphosphate-ribose (ADP)-ribosylation is linked to various diseases. In this review, the roles of PARP1/ARTD1, PARP7/ARTD14, PARP9/ARTD9, and PARP14/ARTD8 in macrophages are discussed. PARPs/ARTs regulate macrophage changes in chronic inflammation through catalytic and non-catalytic mechanisms. Understanding these complex mechanisms and developing innovative technologies are crucial for the development of new therapeutics.
Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is associated with multiple disease processes such as infections and chronic inflammatory diseases. The poly(ADP-ribose) polymerase (PARP)/ADP-ribosyltransferase (ART) family members promote mono- or poly-ADP-ribosylation. Although evidence has linked PARPs/ARTs and macrophages in the context of chronic inflammation, the underlying mechanisms remain incompletely understood. This review provides an overview of literature focusing on the roles of PARP1/ARTD1, PARP7/ARTD14, PARP9/ARTD9, and PARP14/ARTD8 in macrophages. PARPs/ARTs regulate changes in macrophages during chronic inflammatory processes not only via catalytic modifications but also via non-catalytic mechanisms. Untangling complex mechanisms, by which PARPs/ARTs modulate macrophage phenotype, and providing molecular bases for the development of new therapeutics require the development and implementation of innovative technologies.
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