Journal
NATURE IMMUNOLOGY
Volume 17, Issue 3, Pages 323-330Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3348
Keywords
-
Categories
Funding
- National Health and Medical Research Council of Australia [361646, 575500, 1054925, 1054618, 1023454, 1049416]
- Sylvia and Charles Viertel Foundation
- Multiple Myeloma Research Foundation
- Boehringer Ingelheim (Busslinger laboratory)
- European Research Council (LymphoControl for the Busslinger laboratory) [291740]
- Victorian State Government Operational Infrastructure Support
- European Research Council (ERC) [291740] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found that while IRF4 was essential for the survival of plasma cells, Blimp-1 was dispensable for this. Blimp-l-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted to that response, with Blimp-1 uniquely regulating activity of the kinase mTOR and the size of plasma cells. Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available