Journal
NATURE IMMUNOLOGY
Volume 17, Issue 2, Pages 204-213Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3328
Keywords
-
Categories
Funding
- Cancer Research UK
- UK Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre
- King's College London
- King's College Hospital NHS Foundation Trust
- Wellcome Trust
- Cancer Research UK [19309] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [836374] Funding Source: researchfish
- Versus Arthritis
- Cancer Research UK [20265] Funding Source: researchfish
Ask authors/readers for more resources
Adjuvanted vaccines afford invaluable protection against disease, and the molecular and cellular changes they induce offer direct insight into human immunobiology. Here we show that within 24 h of receiving adjuvanted swine flu vaccine, healthy individuals made expansive, complex molecular and cellular responses that included overt lymphoid as well as myeloid contributions. Unexpectedly, this early response was subtly but significantly different in people older than similar to 35 years. Wide-ranging adverse clinical events can seriously confound vaccine adoption, but whether there are immunological correlates of these is unknown. Here we identify a molecular signature of adverse events that was commonly associated with an existing B cell phenotype. Thus immunophenotypic variation among healthy humans may be manifest in complex pathophysiological responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available