Journal
NATURE GENETICS
Volume 48, Issue 6, Pages 667-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/ng.3562
Keywords
-
Categories
Funding
- NHMRC project grant [1031333]
- NHMRC Fellowship scheme
- Joseph Mitchell Trust
- Cancer Research UK [C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565, C490/A10124, C1287/A12014]
- Oxford Comprehensive Biomedical Research Centre
- Rhodes Trust
- Nuffield Department of Medicine
- European Community's Seventh Framework Programme (COGS) [223175, HEALTH-F2-2009-223175]
- US National Institutes of Health [R01 CA128978, U19 CA148537, U19 CA148065, U19 CA148112]
- US Department of Defense [W81XWH-10-1-0341]
- Canadian Institutes of Health Research (CIHR) for CIHR Team in Familial Risks of Breast Cancer
- Susan G. Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- NHMRC [1031333, 339435, 552402]
- Cancer Council Queensland [4196615]
- Cancer Council Tasmania [403031, 457636]
- UK Medical Research Council [G0000934]
- Wellcome Trust [068545/Z/02, 085475]
- European Union's Framework Programme 7 CHIBCHA grant
- Wellcome Trust Centre for Human Genetics Core Grant [090532/Z/09Z]
- ELAN fund of the University of Erlangen
- Rudolf Bartling Foundation
- Verelst Foundation for Endometrial Cancer
- National Cancer Institute of the US Public Health Service [R01 CA122443, P30 CA15083, P50 CA136393]
- Fred C. and Katherine B. Andersen Foundation
- Mayo Foundation
- Helse Vest Grant
- University of Bergen
- Melzer Foundation
- Norwegian Cancer Society (Harald Andersens legat)
- Research Council of Norway
- Haukeland University Hospital
- Stockholm County Council
- Karolinska Institutet [20110222, 20110483, 20110141, DF 07015]
- Swedish Labor Market Insurance [100069]
- Swedish Cancer Society [11 0439]
- Agency for Science, Technology and Research of Singapore (A*STAR)
- US National Institutes of Health
- Susan G. Komen Breast Cancer Foundation
- UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge
- MRC [G0000934, MC_U127527198, MC_PC_U127527198] Funding Source: UKRI
- Academy of Medical Sciences (AMS) [AMS-CSF4-Church] Funding Source: researchfish
- Cancer Research UK [10118, 18927, 16565, 16561, 12076] Funding Source: researchfish
- Medical Research Council [1243081, G0000934, MC_PC_U127527198, MC_U127527198] Funding Source: researchfish
- National Institute for Health Research [CL-2010-13-007] Funding Source: researchfish
- The Francis Crick Institute
- Cancer Research UK [10119, 10124] Funding Source: researchfish
Ask authors/readers for more resources
We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identified five new risk loci of genome-wide significance at likely regulatory regions on chromosomes 13q22.1 (rs11841589, near KLF5), 6q22.31 (rs13328298, in LOC643623 and near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in EIF2AK4, near BMF) and 14q32.33 (rs2498796, in AKT1, near SIVA1). We also found a second independent 8q24.21 signal (rs17232730). Functional studies of the 13q22.1 locus showed that rs9600103 (pairwise r(2) = 0.98 with rs11841589) is located in a region of active chromatin that interacts with the KLF5 promoter region. The rs9600103[T] allele that is protective in endometrial cancer suppressed gene expression in vitro, suggesting that regulation of the expression of KLF5, a gene linked to uterine development, is implicated in tumorigenesis. These findings provide enhanced insight into the genetic and biological basis of endometrial cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
