Journal
MICROORGANISMS
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms11081881
Keywords
Mycobacterium tuberculosis; whole-genome sequencing; phylogenetic analysis
Categories
Ask authors/readers for more resources
The association between tuberculosis and type 2 diabetes mellitus is a challenge in managing the convergence of these epidemics. Our study aimed to determine the diversity of Mycobacterium tuberculosis genotypes in patients with and without type 2 diabetes.
The association of tuberculosis and type 2 diabetes mellitus has been a recognized re-emerging challenge in management of the convergence of the two epidemics. Though much of the literature has studied this association, there is less knowledge in the field of genetic diversities that might occur in strains infecting tuberculosis patients with and without diabetes. Our study focused on determining the extent of diversity of genotypes of Mycobacterium tuberculosis in both these categories of patients. We subjected 55 M. tuberculosis isolates from patients diagnosed with pulmonary TB with and without type 2 diabetes mellitus to whole-genome sequencing on Illumina Hi Seq platform. The most common lineage identified was lineage 1, the Indo-Oceanic lineage (n = 22%), followed by lineage 4, the Euro-American lineage (n = 18, 33%); lineage 3, the East-African Indian lineage (n = 13, 24%); and lineage 2, the East-Asian lineage (n = 1, 2%). There were no significant differences in the distribution of lineages in both diabetics and non-diabetics in the South Indian population, and further studies involving computational analysis and comparative transcriptomics are needed to provide deeper insights.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available