Journal
NATURE GENETICS
Volume 48, Issue 8, Pages 940-+Publisher
NATURE RESEARCH
DOI: 10.1038/ng.3603
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Funding
- China Scholarship Council [201406380127]
- National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
- G. Koukis, an Arthritis Research UK Special Strategic Award
- Wellcome Trust [085492]
- MRC [L002604/1]
- Key Basic Research Program of China [2014CB541901, 2012CB722404, 2011CB512103]
- National Natural Science Foundation of China [81402590, 81371722, 81320108016, 81171505]
- Research Project of the Chinese Ministry of Education [213018A]
- Program for New Century Excellent Talents in University [NCET-12-0600]
- Natural Science Fund of Anhui Province [1408085MKL27]
- Research Grant Council of the Hong Kong Government [GRF HKU783813M, HKU 784611M, 17125114, HKU 770411M]
- Health and Medical Research Fund from the Food and Health Bureau, Hong Kong [12133701]
- National Institute on Aging [U01AG009740, RC2AG036495, RC4AG039029]
- French PHRC Ministere de la Sante
- SLE GWAS in Hong Kong
- MRC [MR/L002604/1] Funding Source: UKRI
- Medical Research Council [MR/L002604/1] Funding Source: researchfish
- Versus Arthritis [19289, 20580] Funding Source: researchfish
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Systemic lupus erythematosus ( SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies ( GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese ( 1,659 cases and 3,398 controls) and European ( 4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese ( 3,043 cases and 5,074 controls) and European ( 2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans ( including Asians) has a genetic basis.
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