Journal
NATURE GENETICS
Volume 49, Issue 1, Pages 152-156Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3736
Keywords
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Categories
Funding
- National Institute of Mental Health [R01MH100351]
- NARSAD Young Investigator award
- South-East Norway Regional Health Authority [2016-064]
- Research Council of Norway through a FRIPRO Mobility Grant [251134]
- European Union's Seventh Framework Programme for research, technological development and demonstration under Marie Curie grant [608695]
- Lister Institute Prize fellowship
- US National Institutes of Health NIDA [R01-DA017932, R01-DA034076]
- Innovative Medicines Initiative Joint Undertaking [115008]
- European Union's Seventh Framework Programme (FP7)
- EU [GA 28613]
- National Institute of Mental Health [R01MH100351]
- NARSAD Young Investigator award
- South-East Norway Regional Health Authority [2016-064]
- Research Council of Norway through a FRIPRO Mobility Grant [251134]
- European Union's Seventh Framework Programme for research, technological development and demonstration under Marie Curie grant [608695]
- Lister Institute Prize fellowship
- US National Institutes of Health NIDA [R01-DA017932, R01-DA034076]
- Innovative Medicines Initiative Joint Undertaking [115008]
- European Union's Seventh Framework Programme (FP7)
- EU [GA 28613]
- MRC [UKDRI-3003, MR/L023784/2, MR/P005748/1] Funding Source: UKRI
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH100351] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG050595, R01AG022381, R01AG018386] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA017932, R01DA034076] Funding Source: NIH RePORTER
- Medical Research Council [MR/P005748/1, MR/L010305/1, MR/L023784/2, UKDRI-3003] Funding Source: researchfish
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Personality is influenced by genetic and environmental factors(1) and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci(2,3), significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132-260,861). Of these genome-wide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3MBTL2. We performed a principal component analysis to extract major dimensions underlying genetic variations among five personality traits and six psychiatric disorders (N = 5,422-18,759). The first genetic dimension separated personality traits and psychiatric disorders, except that neuroticism and openness to experience were clustered with the disorders. High genetic correlations were found between extraversion and attention-deficit- hyperactivity disorder (ADHD) and between openness and schizophrenia and bipolar disorder. The second genetic dimension was closely aligned with extraversion-introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxiety).
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