Journal
MICROORGANISMS
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms11092311
Keywords
bacteriophage; phage therapy; phage engineering; phage display
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Bacterial infections have become a global threat, and bacteriophages are gaining attention as promising alternatives due to their distinctive attributes and genetic modification abilities. Phage engineering can enhance diagnostics, drug delivery, and therapy, and holds promise in transforming precision medicine, addressing antibiotic resistance, and advancing diverse applications.
Amid the escalating challenges of antibiotic resistance, bacterial infections have emerged as a global threat. Bacteriophages (phages), viral entities capable of selectively infecting bacteria, are gaining momentum as promising alternatives to traditional antibiotics. Their distinctive attributes, including host specificity, inherent self-amplification, and potential synergy with antibiotics, render them compelling candidates. Phage engineering, a burgeoning discipline, involves the strategic modification of bacteriophages to enhance their therapeutic potential and broaden their applications. The integration of CRISPR-Cas systems facilitates precise genetic modifications, enabling phages to serve as carriers of functional genes/proteins, thereby enhancing diagnostics, drug delivery, and therapy. Phage engineering holds promise in transforming precision medicine, addressing antibiotic resistance, and advancing diverse applications. Emphasizing the profound therapeutic potential of phages, this review underscores their pivotal role in combatting bacterial diseases and highlights their significance in the post-antibiotic era.
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