Journal
NATURE GENETICS
Volume 48, Issue 3, Pages 299-307Publisher
NATURE PORTFOLIO
DOI: 10.1038/ng.3495
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Funding
- Wellcome Trust [094462/Z/10/Z, 098051]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [24310142, 21590466, 24780044]
- KAKENHI [221S0002]
- Integrated Research Project for Human and Veterinary Medicine of the University of Miyazaki
- Academia Sinica
- US National Institutes of Health (NIH) [AI050668, AI105856]
- Resource-Related Research Grant from the US NIH [RR02512]
- US NIH training [AI060516]
- Max Planck Society
- Wellcome Trust [094462/Z/10/Z] Funding Source: Wellcome Trust
- Grants-in-Aid for Scientific Research [21590466, 221S0002, 24780044] Funding Source: KAKEN
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Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their close relatives that are facultatively parasitic (Parastrongyloides frichosuri) and free-living (Rhabditophanes sp. KR3021). A significant paralogous expansion of key gene families families encoding astacin-like and SCP/TAPS proteins is associated with the evolution of parasitism in this Glade. Exploiting the unique Strongyloides life cycle, we compare the transcriptomes of the parasitic and free-living stages and find that these same gene families are upregulated in the parasitic stages, underscoring their role in nematode parasitism.
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