Journal
MICROORGANISMS
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms11092149
Keywords
secondary metabolism; flux balance analysis; COBRA; multi-objective flux optimization; systems biology; metabolic engineering; synthesis optimization
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Secondary metabolites play a critical role in microbial interactions with the environment and have important ecological, agricultural, medicinal, and industrial uses. Industrial-scale microbial production is a green and economically attractive alternative. In silico multi-objective analysis of metabolism using genome-scale models is an ideal method for studying this field.
Secondary metabolites are not essential for the growth of microorganisms, but they play a critical role in how microbes interact with their surroundings. In addition to this important ecological role, secondary metabolites also have a variety of agricultural, medicinal, and industrial uses, and thus the examination of secondary metabolism of plants and microbes is a growing scientific field. While the chemical production of certain secondary metabolites is possible, industrial-scale microbial production is a green and economically attractive alternative. This is even more true, given the advances in bioengineering that allow us to alter the workings of microbes in order to increase their production of compounds of interest. This type of engineering requires detailed knowledge of the chassis organism's metabolism. Since the resources and the catalytic capacity of enzymes in microbes is finite, it is important to examine the tradeoffs between various bioprocesses in an engineered system and alter its working in a manner that minimally perturbs the robustness of the system while allowing for the maximum production of a product of interest. The in silico multi-objective analysis of metabolism using genome-scale models is an ideal method for such examinations.
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