Journal
NATURE GENETICS
Volume 48, Issue 12, Pages 1557-1563Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3708
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Funding
- Netherlands organization for health research and development (ZonMw) [90.700.441]
- Wellcome Trust [100114]
- NIHR Cardiovascular Biomedical Research Unit at Barts
- London School of Medicine and Dentistry, Queen Mary University of London
- Netherlands Heart Institute
- Marie Sklodowska-Curie Global Fellowship [661395]
- Medical Research Council [MC_qA137853] Funding Source: researchfish
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Resting heart rate is a heritable trait correlated with life span. Little is known about the genetic contribution to resting heart rate and its relationship with mortality. We performed a genome-wide association discovery and replication analysis starting with 19.9 million genetic variants and studying up to 265,046 individuals to identify 64 loci associated with resting heart rate (P < 5 x 10(-8)); 46 of these were novel. We then used the genetic variants identified to study the association between resting heart rate and all-cause mortality. We observed that a genetically predicted resting heart rate increase of 5 beats per minute was associated with a 20% increase in mortality risk (hazard ratio 1.20, 95% confidence interval 1.11-1.28, P = 8.20 x 10(-7)) translating to a reduction in life expectancy of 2.9 years for males and 2.6 years for females. Our findings provide evidence for shared genetic predictors of resting heart rate and all-cause mortality.
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