Journal
MICROORGANISMS
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms11092179
Keywords
respiratory syncytial virus; RSV; influenza; SARS-CoV-2; COVID-19; interferons; IFN; immunity
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This review examines the roles and functions of type I, II, and III IFN responses to respiratory virus infections, as well as the specific IFN responses underlying immunity and protection from disease.
Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on various factors. In this review, the role and function of type I, II, and III IFN responses to respiratory virus infections are considered. In addition, the role of the viral proteins in modifying anti-viral immunity is noted, as are the specific IFN responses that underly the correlates of immunity and protection from disease.
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