Journal
NATURE GENETICS
Volume 48, Issue 4, Pages 356-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/ng.3503
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Funding
- Translational and Integrative Medicine Research Fund
- Cycle for Survival
- Josie Robertson Foundation
- Marie-Josee and Henry R. Kravis Center for Molecular Oncology
- Sloan Kettering Institute for Cancer Research Cancer Center [P30CA008748]
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Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration.
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