4.6 Article

AfLaeA, a Global Regulator of Mycelial Growth, Chlamydospore Production, Pathogenicity, Secondary Metabolism, and Energy Metabolism in the Nematode-Trapping Fungus Arthrobotrys flagrans

Related references

Note: Only part of the references are listed.
Article Microbiology

Establishment of Arthrobotrys flagrans as biocontrol agent against the root pathogenic nematode Xiphinema index

Valentin Wernet et al.

Summary: Plant-parasitic nematodes cause significant agricultural damage worldwide, and the limited availability of synthetic nematicides calls for sustainable and environmentally friendly alternatives. This study examined the use of nematode-trapping fungi as bio-control agents against the wine pathogenic nematode Xiphinema index. Additionally, the study explored the potential of using certain bacteria to induce trap formation in the nematode-trapping fungi to enhance biocontrol efficacy in nematode-infested soil.

ENVIRONMENTAL MICROBIOLOGY (2023)

Article Biochemistry & Molecular Biology

The complex Tup1-Cyc8 bridges transcription factor ClrB and putative histone methyltransferase LaeA to activate the expression of cellulolytic genes

Xiujun Zhang et al.

Summary: This study reveals a transcriptional regulatory mechanism involving Penicillium oxalicum transcription factor ClrB (PoClrB), complex Tup1-Cyc8, and putative histone methyltransferase LaeA (PoLaeA) in the regulation of cellulolytic genes. PoClrB binds to the promoters of cellulolytic genes and recruits the PoTup1-Cyc8 complex, while PoTup1 interacts with PoCyc8 to form the coactivator complex. PoTup1 then recruits putative histone methyltransferase PoLaeA to modify the chromatin structure of the upstream region of cellulolytic genes, facilitating their transcriptional activation.

MOLECULAR MICROBIOLOGY (2022)

Article Genetics & Heredity

The STRIPAK component SipC is involved in morphology and cell-fate determination in the nematode-trapping fungus Duddingtonia flagrans

Valentin Wernet et al.

Summary: The STRIPAK complex plays a crucial role in filamentous fungi, controlling multicellular development, hyphal fusion, and pathogenicity. In the nematode-trapping fungus, a lack of STRIPAK component leads to incomplete trap formation, affecting its trapping function.

GENETICS (2022)

Article Microbiology

MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae

Ying-Ying Cai et al.

Summary: This study reveals that MoOpy2 plays an essential role in fungal development, appressorium penetration, autophagy, and pathogenesis of Magnaporthe oryzae.

ENVIRONMENTAL MICROBIOLOGY (2022)

Article Genetics & Heredity

Autophagy-related protein UvAtg7 contributes to mycelial growth, virulence, asexual reproduction and cell stress response in rice false smut fungus Ustilaginoidea virens

Junjie Yu et al.

Summary: The study indicates that UvAtg7 plays an important role in the autophagy pathway and contributes to mycelial growth, virulence, asexual reproduction, and cell stress response in Ustilaginoidea virens.

FUNGAL GENETICS AND BIOLOGY (2022)

Article Plant Sciences

PhcA and PhcR Regulate Ralsolamycin Biosynthesis Oppositely in Ralstonia solanacearum

Peng Li et al.

Summary: This study demonstrated the important role of ralsolamycin in the crosstalk between R. solanacearum and fungi. Ralsolamycin biosynthesis is regulated by multiple factors, and the transcription factors PhcA and PhcR were found to bind to the promoter of the rmy operon and modulate ralsolamycin production in opposite ways.

FRONTIERS IN PLANT SCIENCE (2022)

Article Microbiology

AoSsk1, a Response Regulator Required for Mycelial Growth and Development, Stress Responses, Trap Formation, and the Secondary Metabolism in Arthrobotrys oligospora

Ke-Xin Jiang et al.

Summary: The Ssk1 protein is an important regulator in the cellular response to hyperosmotic stress in fungi. In this study, an ortholog of Ssk1 was characterized in the nematode-trapping fungus Arthrobotrys oligospora. The deletion of this ortholog resulted in defective growth, abnormal cell morphology, reduced conidial yield, and decreased tolerance to stress. Additionally, the loss of this protein led to an increase in trap formation and predation efficiency. These findings highlight the crucial role of this protein in various biological processes and its potential in understanding the regulatory mechanisms of nematode-trapping fungi.

JOURNAL OF FUNGI (2022)

Article Microbiology

The Velvet Protein UvVEA Regulates Conidiation and Chlamydospore Formation in Ustilaginoidea virens

Mina Yu et al.

Summary: This study identified and characterized two velvet genes in the rice false smut pathogen Ustilaginoidea virens. The deletion of these genes affected the conidiation and glucose utilization of the pathogen. These findings provide insights into the regulatory mechanisms underlying rice false smut ball formation.

JOURNAL OF FUNGI (2022)

Review Biotechnology & Applied Microbiology

Overview of the nematophagous fungus Duddingtonia flagrans

Huarlen Marcio Balbino et al.

Summary: The importance of biological control in agriculture and livestock has led to an increase in research on efficient microorganisms. Duddingtonia flagrans has been studied for the management of parasitic nematodes and plant growth promotion.

BIOCONTROL SCIENCE AND TECHNOLOGY (2022)

Article Microbiology

Identification and Mechanism of Action of the Global Secondary Metabolism Regulator SaraC in Stereum hirsutum

Qian-Yi Hu et al.

Summary: DNA methylation is known to regulate gene expression, but in this study, the researchers discovered a protein called SaraC that has the ability to bind to DNA and demethylate it. By overexpressing SaraC in Stereum hirsutum, the researchers found that it can effectively stimulate the expression of genes related to secondary metabolism, leading to increased production of hybrid polyketides. This discovery suggests that SaraC could be a valuable tool for mining secondary metabolites in fungi.

MICROBIOLOGY SPECTRUM (2022)

Article Microbiology

The BcLAE1 is involved in the regulation of ABA biosynthesis in Botrytis cinerea TB-31

Zhao Wei et al.

Summary: This study demonstrates the important role of BcLAE1 in the regulation of ABA biosynthesis in Botrytis cinerea, and further reveals its involvement in secondary metabolism and epigenetic regulation.

FRONTIERS IN MICROBIOLOGY (2022)

Article Microbiology

AMPK Is Involved in Regulating the Utilization of Carbon Sources, Conidiation, Pathogenicity, and Stress Response of the Nematode-Trapping Fungus Arthrobotrys oligospora

Wenjie Wang et al.

Summary: This study characterized the function of AMPK in the nematode-trapping fungus Arthrobotrys oligospora. AMPK was found to play a crucial role in carbon source utilization, lipid metabolism, stress response, and nematode predation. The study provides new insights into the regulatory mechanisms of trap development and lays the foundation for the development of efficient nematode biocontrol agents.

MICROBIOLOGY SPECTRUM (2022)

Article Microbiology

A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi

Qin Luo et al.

Summary: This study demonstrates the regulatory role of the methyltransferase LaeA in ganoderic acid biosynthesis in the basidiomycete Ganoderma lingzhi. Deletion of laeA leads to reduced concentration of ganoderic acids and transcription levels of related genes, while constitutive overexpression of laeA results in increased concentration of ganoderic acids.

FRONTIERS IN MICROBIOLOGY (2022)

Article Mycology

Requirement of LaeA for sporulation, pigmentation and secondary metabolism in Chaetomium globosum

Ming Cheng et al.

Summary: The global regulator LaeA plays a crucial role in governing the production of secondary metabolites in fungi. In Chaetomium globosum, CgLaeA significantly impacts secondary metabolism and fungal morphological phenotypes by regulating the expression of pathway-specific transcription factors and other global regulators. Moreover, overexpression of CglaeA can enhance the production of certain secondary metabolites.

FUNGAL BIOLOGY (2021)

Article Microbiology

The small-secreted cysteine-rich protein CyrA is a virulence factor participating in the attack of Caenorhabditis elegans by Duddingtonia flagrans

Nicole Wernet et al.

Summary: Pathogenic microorganisms have different strategies to interact with their hosts, some modulate the host to obtain nutrients while others quickly kill and consume the host for energy. Predatory fungi produce a large number of small-secreted proteins to regulate the predation process, which is crucial for the predatory relationship between fungi and nematodes.

PLOS PATHOGENS (2021)

Article Microbiology

Pathogenicity and Volatile Nematicidal Metabolites from Duddingtonia flagrans against Meloidogyne incognita

Xiaoyu Mei et al.

Summary: The volatile organic compounds produced by Duddingtonia flagrans exhibit potential biocontrol activity against plant root-knot nematodes, with cyclohexanamine showing the highest nematicidal activity.

MICROORGANISMS (2021)

Article Multidisciplinary Sciences

Fatal attraction of Caenorhabditis elegans to predatory fungi through 6-methyl-salicylic acid

Xi Yu et al.

Summary: The study revealed that the nematode-trapping fungus Duddingtonia flagrans utilizes 6-MSA to control trap formation and attract Caenorhabditis elegans. This compound plays a crucial role in interkingdom communication between fungi and nematodes.

NATURE COMMUNICATIONS (2021)

Article Microbiology

Transcriptome Dynamics Underlying Chlamydospore Formation in Trichoderma virens GV29-8

Xinhong Peng et al.

Summary: Trichoderma species are widely used biocontrol agents with antagonistic properties against various plant pathogens. Chlamydospores, produced by many fungi, have thick walls and high resistance to adverse conditions. Chlamydospores of Trichoderma spp. have better application potential and longer shelf life, but large-scale production remains difficult. By conducting a comprehensive analysis of transcriptome dynamics during chlamydospore formation, important pathways and genes involved in each stage were identified.

FRONTIERS IN MICROBIOLOGY (2021)

Article Biotechnology & Applied Microbiology

LaeA Controls Citric Acid Production through Regulation of the Citrate Exporter-Encoding cexA Gene in Aspergillus luchuensis mut. kawachii

Chihiro Kadooka et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2020)

Article Biotechnology & Applied Microbiology

Overexpression of global regulator LaeA increases secondary metabolite production in Monascus purpureus

Chan Zhang et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Microbiology

MoLAEA Regulates Secondary Metabolism in Magnaporthe oryzae

Pallabi Saha et al.

MSPHERE (2020)

Review Biotechnology & Applied Microbiology

New knowledge about the biosynthesis of lovastatin and its production by fermentation ofAspergillus terreus

Javier Barrios-Gonzalez et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans

Arturo Hernandez-Cervantes et al.

NATURE COMMUNICATIONS (2020)

Article Microbiology

LaeA Controls Virulence and Secondary Metabolism in Apple Canker Pathogen Valsa mali

Yaqiong Feng et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Plant Sciences

Fusaric acid contributes to virulence of Fusarium oxysporum on plant and mammalian hosts

Cristina Lopez-Diaz et al.

MOLECULAR PLANT PATHOLOGY (2018)

Article Food Science & Technology

Insight into the global regulation of laeA in Aspergillus flavus based on proteomic profiling

Yangyong Lv et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2018)

Article Biotechnology & Applied Microbiology

Sugar versus fat: elimination of glycogen storage improves lipid accumulation in Yarrowia lipolytica

Govindprasad Bhutada et al.

FEMS YEAST RESEARCH (2017)

Article Genetics & Heredity

LaeA negatively regulates dothistromin production in the pine needle pathogen Dothistroma septosporum

Pranav Chettri et al.

FUNGAL GENETICS AND BIOLOGY (2016)

Article Food Science & Technology

LaeA and VeA are involved in growth morphology, asexual development, and mycotoxin production in Alternaria alternata

N. Estiarte et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2016)

Article Microbiology

Candida species Rewired Hyphae Developmental Programs for Chlamydospore Formation

Bettina Bottcher et al.

FRONTIERS IN MICROBIOLOGY (2016)

Article Food Science & Technology

VeA and LaeA transcriptional factors regulate ochratoxin A biosynthesis in Aspergillus carbonarius

A. Crespo-Sempere et al.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2013)

Article Genetics & Heredity

Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator

Razieh Karimi-Aghcheh et al.

G3-GENES GENOMES GENETICS (2013)

Article Genetics & Heredity

Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides

Robert A. E. Butchko et al.

FUNGAL GENETICS AND BIOLOGY (2012)

Article Multidisciplinary Sciences

The Role, Interaction and Regulation of the Velvet Regulator VelB in Aspergillus nidulans

Hee-Soo Park et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Aspergillus oryzae laeA Regulates Kojic Acid Synthesis Genes

Ken Oda et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2011)

Review Genetics & Heredity

Regulation of secondary metabolism by chromatin structure and epigenetic codes

Joseph Strauss et al.

FUNGAL GENETICS AND BIOLOGY (2011)

Article Biotechnology & Applied Microbiology

Purification and germination of Candida albicans and Candida dubliniensis chlamydospores cultured in liquid media

Francesco Citiulo et al.

FEMS YEAST RESEARCH (2009)

Article Multidisciplinary Sciences

Evolution of nematode-trapping cells of predatory fungi of the Orbiliaceae based on evidence from rRNA-encoding DNA and multiprotein sequences

Ying Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Microbiology

LaeA, a regulator of secondary metabolism in Aspergillus spp.

JW Bok et al.

EUKARYOTIC CELL (2004)

Article Biochemistry & Molecular Biology

Influence of activated A and B mating-type pathways on developmental processes in the basidiomycete Coprinus cinereus

U Kües et al.

MOLECULAR GENETICS AND GENOMICS (2002)

Review Microbiology

Life history and developmental processes in the basidiomycete Coprinus cinereus

U Kües

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2000)