Discovery of an endogenous foamy virus in primitive ruminant chevrotains

Foamy viruses (FVs) are a class of complex retroviruses that could lead to persistent infections in specific species. FVs have two evolutionary characteristics: the first is co-evolution with the host, and the second is difficulty going through the endogenization process. To date, in mammals, only a few species (aye-aye, sloths, and cape golden mole) have been found to have endogenous forms of FVs. In this study, we identified a novel endogenous FV named TraEFV in the genomes of two species of even-toed ungulate chevrotain (genus Tragulus, family Tragulidae) known as mouse-deer. Phylogenetic analysis clustered TraEFVs with an exogenous FV isolated from feline but not with those isolated from cow and horse, and such inconsistent virus-host relationships reflect their complex evolutionary history. Interestingly, TraEFVs could be divided into two lineages, suggesting that TraEFV invaded these hosts at least twice during ancient times. Finally, the molecular clock estimates that TraEFV is approximately 20 million years old, suggesting its ancient nature. Our findings enrich the host taxonomy of spumaretroviruses.

Automated summary

A novel endogenous foamy virus, named TraEFV, was discovered in the genomes of two even-toed ungulate chevrotains. Phylogenetic analysis showed that TraEFV is more closely related to exogenous foamy viruses from feline rather than those from cow and horse. Additionally, TraEFV could be divided into two lineages, indicating multiple ancient invasions of the host species. This study enriches the host taxonomy of spumaretroviruses.