Journal
NATURE GENETICS
Volume 48, Issue 5, Pages 478-479Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.3554
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How maternal diet influences offspring metabolism is unclear, as it is difficult to distinguish between the effects of the in utero environment and epigenetic factors contributed by the oocyte. In a mouse model of high-fat diet, a new study teases apart these mechanisms by using in vitro fertilization and shows that susceptibility of offspring to metabolic disorder can likely be attributed to epigenetic inheritance via the oocyte.
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