Bilirubin and Redox Stress in Age-Related Brain Diseases

Article Pediatrics

Models of bilirubin neurological damage: lessons learned and new challenges

Silvia Gazzin et al.

Summary: This article reviews the key mechanisms of objective jaundice and the available models and technologies for translational research. It points out the challenges and gaps in translation and suggests new clinical research opportunities.

PEDIATRIC RESEARCH (2023)

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Article Neurosciences

Bilirubin induces microglial NLRP3 inflammasome activation in vitro and in vivo

Ilkcan Ercan et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2023)

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Review Biochemistry & Molecular Biology

Cytoprotective Role of Heme Oxygenase-1 in Cancer Chemoresistance: Focus on Antioxidant, Antiapoptotic, and Pro-Autophagy Properties

Huan Wang et al.

Summary: Chemoresistance is a major challenge in cancer therapy. Tumor cells have high levels of reactive oxygen species (ROS), making them more susceptible to further ROS increase than normal cells. However, tumor cells can counteract therapy-induced oxidative stress, leading to chemoresistance. Therefore, understanding the cytoprotective mechanisms of tumor cells is necessary to overcome chemoresistance.

ANTIOXIDANTS (2023)

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Article Neurosciences

Oxidative Stress Biomarkers among Schizophrenia Inpatients

Magdalena Więdłocha et al.

Brain Sciences (2023)

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Article Biology

Bilirubin-Induced Transcriptomic Imprinting in Neonatal Hyperbilirubinemia

John Paul Llido et al.

Summary: Severe neonatal hyperbilirubinemia can lead to brain damage and cause motor, cognitive, and auditory abnormalities. Bilirubin has been found to control the genetic development of the cerebellum, which is susceptible to bilirubin-induced damage. This study expands the research on the impact of bilirubin on postnatal brain development in regions that correlate with human symptoms. The findings show temporary alterations in gene expression in areas related to memory, learning, cognition, and auditory functions, but permanent changes in areas controlling movements, which coincide with clinical descriptions of bilirubin-induced neurotoxicity.

BIOLOGY-BASEL (2023)

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Review Psychiatry

The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders - A systematic review of magnetic resonance spectroscopy studies

Mounica Reddy-Thootkur et al.

Summary: There is considerable overlap between schizophrenia and mood disorders, both of which are associated with cognitive deficits and altered glutamatergic and GABAergic neurometabolism. However, the relationship between these neurotransmitters and cognitive dysfunction in mental illness is still not well understood.

SCHIZOPHRENIA RESEARCH (2022)

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Article Psychiatry

Ultrastructural evidence for glutamatergic dysregulation in schizophrenia

Rosalinda C. Roberts et al.

Summary: The aim of this paper is to summarize ultrastructural evidence for glutamatergic dysregulation in postmortem schizophrenia brain. The study found that synaptic density and balance between excitatory and inhibitory synapses are altered in various regions of the brain in schizophrenia patients. These findings are crucial for understanding the underlying pathology of schizophrenia and developing effective treatment strategies.

SCHIZOPHRENIA RESEARCH (2022)

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Review Cell Biology

Telomere dysfunction in ageing and age-related diseases

Francesca Rossiello et al.

Summary: The article reviews the impact of telomere shortening and dysfunction on aging and a variety of age-related diseases in humans. Accumulation of senescent cells in aging organisms is believed to contribute to bodily dysfunction. Telomere shortening and damage are known causes of cellular senescence and aging. The authors argue that telomeric dysfunction plays a broad role in human pathologies associated with normal aging.

NATURE CELL BIOLOGY (2022)

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Review Neurosciences

Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration

Manish Verma et al.

Summary: Glutamate is a commonly used neurotransmitter in the central nervous system of mammals, but excessive levels can lead to excitotoxicity and neuronal cell death. Excitatory synaptic dysregulation also contributes to neurodegeneration. Optimizing mitochondrial calcium flux can prevent excitatory mitochondrial toxicity and provide neuroprotection in various diseases.

TRANSLATIONAL NEURODEGENERATION (2022)

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Article Biochemistry & Molecular Biology

Altered Metabolism in Alzheimer Disease Brain: Role of Oxidative Stress

Nicole G. Rummel et al.

Summary: Alzheimer's disease is common among the aging population, but aging does not necessarily lead to neurodegeneration and memory decline. Recent research focuses on metabolic changes in the AD brain related to oxidative stress, with potential intervention targets identified. The main issue in AD is an imbalance of oxidative stress, particularly within the central nervous system, leading to disruptions in metabolic processes and cell damage. Understanding the role of reactive oxygen species in these alterations can potentially lead to therapeutic options for slowing the progression of AD.

ANTIOXIDANTS & REDOX SIGNALING (2022)

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Review Biochemistry & Molecular Biology

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

Daniel Mihai Teleanu et al.

Summary: This review summarizes the correlation between oxidative stress and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. It also discusses the impact of oxidative stress on the inflammatory response. Antioxidants are considered potential therapeutic options for these disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Clinical Neurology

Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis

Stephen A. Goutman et al.

Summary: The diagnosis of amyotrophic lateral sclerosis can be challenging due to its diverse clinical presentation and overlap with other neurological disorders. However, an evolving understanding of the disease and the use of new diagnostic criteria can expedite diagnosis. Additionally, advancements in prognosis and monitoring tools are also being developed.

LANCET NEUROLOGY (2022)

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Review Oncology

Alterations in Molecular Profiles Affecting Glioblastoma Resistance to Radiochemotherapy: Where Does the Good Go?

Juliana B. Vilar et al.

Summary: Glioblastoma is a type of brain cancer that remains incurable, with patients showing resistance to standard radio-chemotherapy. Current treatments involving surgery, radiotherapy, and chemotherapy have been administered for over 15 years, with GBM cells exhibiting intrinsic mutations that promote cell survival and tumor regrowth. The mutational background of GBM interferes with the response to standard treatment, leading to poor prognosis and dismal survival rates.

CANCERS (2022)

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Review Biochemistry & Molecular Biology

Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review

Chisato Kinoshita et al.

Summary: Multiple system atrophy is a rare neurodegenerative disease that is characterized by oxidative stress, glutathione deficiency, and dysregulation of miRNA. These factors are closely related to the pathology of MSA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Bilirubin Prevents the TH+ Dopaminergic Neuron Loss in a Parkinson's Disease Model by Acting on TNF-α

Sri Jayanti et al.

Summary: This study investigated the neuroprotective effect of low concentrations of UCB in a PD model and found that UCB could effectively protect against the loss of dopaminergic neurons, with inflammation being the key factor in this protection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Antioxidant Intervention to Improve Cognition in the Aging Brain: The Example of Hydroxytyrosol and Resveratrol

Sergio Terracina et al.

Summary: Both physiological and pathological aging processes can affect brain functions, and exogenous antioxidants, especially those from the Mediterranean diet, may have a positive impact in delaying and improving cognitive functions in the aging brain. Evaluating the preventive activity of antioxidants in long-term exposure clinical trials is essential.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer's disease

Marcos Otero-Garcia et al.

Summary: This study investigates the relationship between Tau protein aggregation in neurofibrillary tangles (NFTs) and Alzheimer's disease (AD). Through high-throughput isolation and transcriptome profiling, the researchers found that NFT-bearing neurons show an upregulation of genes related to synaptic transmission, particularly genes involved in synaptic vesicle cycling. They also observed that mitochondrial dysfunction and oxidative phosphorylation vary among different cell types. Interestingly, the susceptibility to apoptosis and death is similar between NFT-bearing and NFT-free neurons.

NEURON (2022)

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Article Pharmacology & Pharmacy

Bilirubin stabilizes the mitochondrial membranes during NLRP3 inflammasome activation

Yufei Li et al.

Summary: Mitochondria can sense both intracellular and extracellular stress and the resulting release of mt-ROS activates NLRP3 inflammasome. Regulating mitochondrial morphology and function can be a strategy to control inflammation. Bilirubin has anti-inflammatory effects by inhibiting NF-Kappa B and inflammasome activation. It also stabilizes mitochondrial membrane during NLRP3 inflammasome activation, making it a potential targeted medication against inflammasome-related diseases.

BIOCHEMICAL PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Amyotrophic Lateral Sclerosis: Synergy of Genetic and Environmental Factors

Anca Motataianu et al.

Summary: ALS is a severe neurodegenerative disease with a short survival period. Oxidative stress plays a crucial role in the pathogenesis of ALS, and genetic mutations and environmental factors can increase oxidative damage. This review explores how genetic mutations and environmental factors influence the occurrence of oxidative stress in ALS and discusses potential therapeutic molecules.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Medicine, General & Internal

Amyotrophic lateral sclerosis

Eva L. Feldman et al.

Summary: Amyotrophic lateral sclerosis, a fatal CNS neurodegenerative disease, lacks optimal management strategies. Improved understanding of clinical presentation, pathophysiology, and diagnostic criteria has not yet translated into direct patient benefit. However, the concept of amyotrophic lateral sclerosis as a complex syndrome is already influencing clinical practice.

LANCET (2022)

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Review Biochemistry & Molecular Biology

Antioxidants in brain tumors: current therapeutic significance and future prospects

Xuchen Qi et al.

Summary: Brain cancer is one of the most deadly forms of cancer, and brain tumor cells are resistant to conventional and advanced therapies. Antioxidants may prevent tumorigenesis by inhibiting oxidative stress and have chemopreventive and chemotherapeutic effects on brain cancers. They can also minimize chemotherapy-induced toxicity and reverse chemoresistance. However, the effects of antioxidants depend on various factors and conditions, and more mechanistic studies are needed for consistent clinical outcomes.

MOLECULAR CANCER (2022)

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Article Psychiatry

Revisiting the latent structure of negative symptoms in schizophrenia: Evidence from two second-generation clinical assessments br

Shuai-biao Li et al.

Summary: This study examined the latent structure of negative symptoms in schizophrenia using two second-generation negative symptom scales. The results indicate that a 2-factor model, comprising the motivation and pleasure (MAP) domain and the diminished expression (EXP) domain, provided the best fit for the data. Combining the items from both scales further supported the superiority of the 2-factor model. The findings suggest that the MAP and EXP factors represent the latent structure of negative symptoms.

SCHIZOPHRENIA RESEARCH (2022)

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Article Biochemistry & Molecular Biology

New Statement about NRF2 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Isabel Lastres-Becker et al.

Summary: This study provides evidence that the NRF2 signaling pathway is differently affected in ALS and FTD, suggesting a distinct regulatory mechanism for cellular homeostasis in these neurodegenerative disorders.

BIOMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance

Jose Jimenez-Villegas et al.

Summary: The hexanucleotide expansion of the C9orf72 gene is associated with familial amyotrophic lateral sclerosis (ALS). This study found that the expression of redox-related genes was altered in leukocytes from C9orf72 ALS patients. Further experiments revealed that exposure to dipeptide repeat (DPR) toxicity decreased NRF2 protein levels, leading to increased superoxide levels and reduced cell survival. However, activation of NRF2 was able to restore cell viability and redox homeostasis. This suggests that NRF2 may be a potential target for precision medicine in treating ALS patients with C9orf72 expansion repeats.

ANTIOXIDANTS (2022)

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Article Cell & Tissue Engineering

Telomeres and Mitochondrial Metabolism: Implications for Cellular Senescence and Age-related Diseases

Xingyu Gao et al.

Summary: Cellular senescence is closely related to the development of age-related diseases, and metabolic imbalance caused by short telomeres and mitochondrial damages play a significant role. Future studies on telomere and mitochondrial metabolism may provide potential therapeutic strategies for age-related diseases.

STEM CELL REVIEWS AND REPORTS (2022)

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Review Endocrinology & Metabolism

Bilirubin as a metabolic hormone: the physiological relevance of low levels

Justin F. Creeden et al.

Summary: Recent research indicates that bilirubin may have a new role as a metabolic hormone, potentially leading to cardiovascular complications for patients with low levels. Protective mechanisms at mildly elevated levels of bilirubin could offer treatment possibilities for those with hypobilirubinemia.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2021)

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Article Biochemistry & Molecular Biology

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

Xinxin Zuo et al.

Summary: Initially thought to be associated with oxidative stress, ALS is now understood to involve genes related to RNA processing and proteostasis, leading to the convergence of different biological pathways causing the disease. Aggregation of TDP-43 in neurons increases sensitivity to oxidative stress and dysregulates specific miRNAs and proteins, impacting mitochondrial function and promoting ALS initiation and progression.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

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Review Cell Biology

Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives

Evgeny A. Ermakov et al.

Summary: Schizophrenia is a highly heterogeneous disease at various levels, with oxidative stress-related mechanisms playing a significant role in its manifestation and development, involving genetic causes, mitochondrial dysfunction, metabolic abnormalities, and more. These mechanisms ultimately contribute to the occurrence and progression of schizophrenia at the whole-organism level.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Cell Biology

Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey

Lu Hao et al.

Summary: This cross-sectional study using NHANES data found a positive and nonlinear association between total bilirubin concentration and telomere length. Higher total bilirubin concentration was associated with longer telomere length in both males and females. An inverted U-shaped relationship between total bilirubin and telomere length was observed as well.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Neurosciences

Oxidative Stress and Cognitive Decline: The Neuroprotective Role of Natural Antioxidants

Ferdinando Franzoni et al.

Summary: Free-radicals formed during oxidative phosphorylation can lead to oxidative stress in the brain, where antioxidant molecules are crucial in limiting damage. Understanding the relationship between natural antioxidant molecules and the Central Nervous System is key in combating neurodegenerative diseases.

FRONTIERS IN NEUROSCIENCE (2021)

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Article Multidisciplinary Sciences

Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis

Meneca Becklen et al.

Summary: A recent study found that individuals with first-episode psychosis had lower levels of bilirubin, which may contribute to memory impairments. The study also showed that bilirubin levels were related to cognitive function, symptoms and duration of untreated psychosis in these patients.

SCIENTIFIC REPORTS (2021)

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Review Cell & Tissue Engineering

Role of glioblastoma stem cells in cancer therapeutic resistance: a perspective on antineoplastic agents from natural sources and chemical derivatives

Ana Laura V. Alves et al.

Summary: Glioblastoma (GBM) is the highest-grade form of glioma, characterized by rapid cellular growth and high invasiveness. Understanding cancer stem cells (CSCs) has provided new insights into GBM resistance and management. With knowledge of GSCs and therapies based on antineoplastic agents, a promising future in GBM treatment may be on the horizon.

STEM CELL RESEARCH & THERAPY (2021)

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Review Pharmacology & Pharmacy

Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments

Mahmoud S. Alghamri et al.

Summary: Gliomas, particularly glioblastomas, are highly aggressive and lethal cancers with unique molecular characteristics and genetic signatures. The interactions between tumor cells and immune cells in the tumor microenvironment play a critical role in glioma progression. Understanding the impact of inflammation and potential pharmacological interventions targeting neuro-inflammation are important for improving outcomes in glioma patients.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

The Diverse Roles of Heme Oxygenase-1 in Tumor Progression

Kim Ngan Luu Hoang et al.

Summary: HO-1 is an inducible intracellular enzyme expressed in various cancers to promote tumor progression through intracellular and extracellular mechanisms. Its catabolites provide antioxidant, anti-apoptotic, and cytoprotective effects within cells, while also influencing the wider tumor microenvironment to promote processes like angiogenesis, metastasis, anti-inflammation, and immune suppression. Pharmacological inhibition of HO-1 shows promise in inhibiting metastasis and promoting anti-tumor immune responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Bilirubin Induces Pain Desensitization in Cholestasis by Activating 5-Hydroxytryptamine 3A Receptor in Spinal Cord

Erliang Kong et al.

Summary: This study found that bilirubin significantly increased in cholestasis rats, leading to pain desensitization by activating 5-HT3A receptor in the spinal cord. Bilirubin may regulate pain threshold by affecting the GABA pathway.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

New Avenues for the Treatment of Huntington's Disease

Amy Kim et al.

Summary: Huntington's disease is a neurodegenerative disorder caused by a CAG expansion in the HD gene, with symptoms typically appearing in mid-life involving cognitive deficits and motor disturbances. Despite known genetic cause, multiple mechanisms are believed to contribute to neurodegeneration, leading to various pre-clinical and clinical studies testing therapeutic approaches.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Bilirubin: A Promising Therapy for Parkinson's Disease

Sri Jayanti et al.

Summary: With the increase in life expectancy, the prevalence of Parkinson's disease is expected to rise, but the diagnosis still relies on clinical symptoms. Current treatments mainly focus on alleviating symptoms without stopping or slowing down disease progression. Therefore, exploring the therapeutic potential of bilirubin in PD is crucial for the development of disease-modifying treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Gastroenterology & Hepatology

Bilirubin: The yellow hormone?

Libor Vitek et al.

Summary: Bilirubin plays an important role in regulating various biological functions in the human body, including cell signaling, metabolism modulation, and immune regulation. Individuals with chronic mild unconjugated hyperbilirubinemia typically have a lower incidence of civilization diseases, while higher serum concentrations of unconjugated bilirubin may serve as a protective factor against these diseases.

JOURNAL OF HEPATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS

Elizabeth Minj et al.

Summary: Methylmercury (MeHg) is a potent neurotoxin that causes neuronal cell death and demyelination, while AKBA, as a Nrf2/HO-1 activator, shows protective effects in an experimental ALS model.

NEUROCHEMICAL RESEARCH (2021)

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Review Psychiatry

Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders

Alex J. Murray et al.

Summary: Schizophrenia is associated with increased oxidative stress, potentially leading to a worsening of symptoms and poor outcomes. Targeting oxidative stress may be a promising approach for future pharmacotherapy in schizophrenia.

FRONTIERS IN PSYCHIATRY (2021)

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Article Biochemistry & Molecular Biology

Oxidative Stress and Related Biomarkers in Gilbert's Syndrome: A Secondary Analysis of Two Case-Control Studies

Karl-Heinz Wagner et al.

Summary: Subjects with Gilbert's syndrome show higher levels of antioxidant potential and protein oxidation products, as well as lower levels of apolipoprotein B, hs-C-reactive protein, interleukin 6, and interleukin 1 beta compared to healthy controls. Resting heart rate is also significantly lower in the GS group. Older subjects with GS demonstrate stronger protective effects.

ANTIOXIDANTS (2021)

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Article Clinical Neurology

Midlife Atherosclerosis and Development of Alzheimer or Vascular Dementia

Anna-Marta Gustavsson et al.

ANNALS OF NEUROLOGY (2020)

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Review Chemistry, Multidisciplinary

Recent advances in dopaminergic strategies for the treatment of Parkinson's disease

Qi Mao et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Clinical Neurology

Clinical profile in schizophrenia and schizoaffective spectrum: relation with unconjugated bilirubin in a prospective and controlled study with psychopathological and psychosocial variables

Joao Gama Marques et al.

CNS SPECTRUMS (2020)

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Article Biochemistry & Molecular Biology

BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model

Tetsushi Kataura et al.

JOURNAL OF NEUROCHEMISTRY (2020)

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Article Medicine, Research & Experimental

Hemin treatment protects neonatal rats from sevoflurane-induced neurotoxicity via the phosphoinositide 3-kinase/Akt pathway

Fan Yang et al.

LIFE SCIENCES (2020)

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Review Chemistry, Medicinal

Bilirubin as a signaling molecule

Libor Vitek

MEDICINAL RESEARCH REVIEWS (2020)

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Review Cell Biology

Brain lipid peroxidation and alzheimer disease: Synergy between the Butterfield and Mattson laboratories

D. Allan Butterfield

AGEING RESEARCH REVIEWS (2020)

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Article Biochemistry & Molecular Biology

Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator?activated receptor ?

Darren M. Gordon et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System

Eleonora Ficiara et al.

MOLECULES (2020)

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Article Immunology

Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation

Andrew S. Mendiola et al.

NATURE IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders

Sylwia Wojtowicz et al.

NEUROCHEMICAL RESEARCH (2020)

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Review Cell Biology

Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development

Valentina Pegoretti et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Immunology

Physiological concentrations of bilirubin control inflammatory response by inhibiting NF-κB and inflammasome activation

Yufei Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Immunology

Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

Samanta C. Funes et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders

Tao Ming Sim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Neurosciences

Abnormal Serum Bilirubin/Albumin Concentrations in Dementia Patients With A beta Deposition and the Benefit of Intravenous Albumin Infusion for Alzheimer's Disease Treatment

Xiaomei Zhong et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Review Biochemistry & Molecular Biology

The Role of Bilirubin and the Other Yellow Players in Neurodegenerative Diseases

Sri Jayanti et al.

ANTIOXIDANTS (2020)

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Article Pharmacology & Pharmacy

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate

Terry D. Hinds et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Neurosciences

The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma

Maria Jesus Ramirez-Exposito et al.

CURRENT NEUROPHARMACOLOGY (2019)

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Review Neurosciences

The sinister face of heme oxygenase-1 in brain aging and disease

Hyman M. Schipper et al.

PROGRESS IN NEUROBIOLOGY (2019)

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Review Psychiatry

Dementia with Lewy bodies: Challenges in the diagnosis and management

Kai Sin Chin et al.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2019)

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Review Clinical Neurology

Unconjugated bilirubin and schizophrenia: a systematic review

Erik Pommerening Dornelles et al.

CNS SPECTRUMS (2019)

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Article Nutrition & Dietetics

New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients

Ayelet Armon-Omer et al.

NUTRIENTS (2019)

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Article Medicine, Research & Experimental

Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells

Iris Chiara Salaroglio et al.

MOLECULAR PHARMACEUTICS (2019)

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Review Clinical Neurology

DNA Damage Repair in Huntington's Disease and Other Neurodegenerative Diseases

T. Maiuri et al.

NEUROTHERAPEUTICS (2019)

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Article Biochemistry & Molecular Biology

Angiogenin activates the astrocytic Nrf2/antioxidant-response element pathway and thereby protects murine neurons from oxidative stress

Trish T. Hoang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Nanoscience & Nanotechnology

D-T7 Peptide-Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma

Meinan Yu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Pharmacology & Pharmacy

Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

Libor Vitek et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

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Review Neurosciences

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease

Federica Cioffi et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Review Pediatrics

Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders

Sanjiv B. Amin et al.

PEDIATRIC RESEARCH (2019)

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Review Pediatrics

High unbound bilirubin for age: a neurotoxin with major effects on the developing brain

Rowena Cayabyab et al.

PEDIATRIC RESEARCH (2019)

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Article Clinical Neurology

Association of Serum Indirect Bilirubin Concentrations with Motor Subtypes of Parkinson's Disease

Jun Li et al.

NEURODEGENERATIVE DISEASES (2019)

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Review Biochemistry & Molecular Biology

Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target

Mariona Jove et al.

REDOX BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide

Chirag Vasavda et al.

CELL CHEMICAL BIOLOGY (2019)

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Review Clinical Neurology

Diagnosis and management of progressive ataxia in adults

Rajith Nilantha de Silva et al.

PRACTICAL NEUROLOGY (2019)

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Review Biochemistry & Molecular Biology

Redox Signaling in Neurotransmission and Cognition During Aging

Ashok Kumar et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Article Biochemistry & Molecular Biology

Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease

Francesca Triani et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

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Review Immunology

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

Cristina Gutierrez-Vazquez et al.

IMMUNITY (2018)

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Review Medicine, General & Internal

Multiple Sclerosis

Daniel S. Reich et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Psychiatry

Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016

Fiona J. Charlson et al.

SCHIZOPHRENIA BULLETIN (2018)

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Review Neurosciences

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

Zexu Wei et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

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Review Biochemistry & Molecular Biology

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

Mariapaola Nitti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Multidisciplinary Sciences

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

Haibo Wang et al.

NATURE COMMUNICATIONS (2018)

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Review Neurosciences

Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis

Osman Shabir et al.

BMC NEUROSCIENCE (2018)

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Review Neurosciences

Unraveling the Role of Heme in Neurodegeneration

Deborah Chiabrando et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Article Biochemistry & Molecular Biology

Structural requirements of flavonoids to induce heme oxygenase-1 expression

K. D. Croft et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Biochemistry & Molecular Biology

Ligands of peroxisome proliferator-activated receptor-alpha promote glutamate transporter-1 endocytosis in astrocytes

Hui-Ting Huang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)

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Review Medicine, General & Internal

Amyotrophic lateral sclerosis

Michael A. van Es et al.

LANCET (2017)

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Article Clinical Neurology

Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Valery L. Feigin et al.

LANCET NEUROLOGY (2017)

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Review Gastroenterology & Hepatology

The molecular basis of jaundice: An old symptom revisited

Silvia Gazzin et al.

LIVER INTERNATIONAL (2017)

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Article Genetics & Heredity

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

Juyong Brian Kim et al.

PLOS GENETICS (2017)

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Review Psychiatry

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Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction

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PEGylated bilirubin nanoparticle as an anti-oxidative and anti- inflammatory demulcent in pancreatic islet xenotransplantation

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Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human biliverdin reductase

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Bilirubin suppresses Th17 immunity in colitis by upregulating CD39

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PPAR-delta is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

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Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats

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Oxidative Stress and Environmental Exposures are Associated with Multiple System Atrophy in Chinese Patients

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Eel green fluorescent protein is associated with resistance to oxidative stress

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Neonates with sickle cell disease are vulnerable to blue light phototherapy-induced oxidative stress and proinflammatory cytokine elevations

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Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

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Bilirubin and Redox Stress in Age-Related Brain Diseases

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