4.7 Article

Korean Red Ginseng Attenuates Particulate Matter-Induced Senescence of Skin Keratinocytes

Related references

Note: Only part of the references are listed.
Review Cell Biology

Epigenetic Regulation of Cellular Senescence

Jack Crouch et al.

Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).

CELLS (2022)

Article Health Care Sciences & Services

The Interaction among Microbiota, Epigenetic Regulation, and Air Pollutants in Disease Prevention

Alessandra Pulliero et al.

Summary: Environmental pollutants can affect the diversity of microbiota, which has significant implications for overall organism health. Changes in microbiota are associated with the progression of diseases in high-risk individuals, and epigenetic modifications are influenced by microbiota metabolites. Monitoring environmental stimuli to maintain a balanced microbiota presents a novel approach for disease prevention.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Article Dermatology

HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre-Basal Cell Carcinoma through p16 and p53

Xuming Zhu et al.

Summary: The study highlights the crucial roles of HDAC1 and HDAC2 in maintaining proliferation and survival of adult epidermal and basal cell carcinoma progenitors. Deletion of these genes leads to various abnormalities and cell loss, which can be partially rescued by p16 and p53 deletion. Therapeutic efficacy of HDAC1/2 inhibition may depend on the mutational status of p53 and p16.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

Review Plant Sciences

Pharmacological potential of ginseng and its major component ginsenosides

Zubair Ahmed Ratan et al.

Summary: Ginseng, as a traditional herb in Asian countries, has been used for thousands of years and contains a variety of active ingredients with numerous benefits, but further high-quality evidence is needed to prove its medicinal value.

JOURNAL OF GINSENG RESEARCH (2021)

Article Plant Sciences

Korean Red ginseng prevents endothelial senescence by downregulating the HO-1/NF-κB/miRNA-155-5p/eNOS pathway

Tae-Hoon Kim et al.

Summary: The study demonstrated that Korean Red ginseng extract (KRGE) delayed or prevented the senescence of human umbilical vein endothelial cells (HUVECs) through a signaling cascade involving the induction of HO-1, inhibition of NF-kappa B-dependent miR-155-5p biogenesis, and maintenance of the eNOS/NO axis activity.

JOURNAL OF GINSENG RESEARCH (2021)

Article Biochemistry & Molecular Biology

Ginsenoside Rg1 prevents bone marrow mesenchymal stem cell senescence via NRF2 and PI3K/Akt signaling

Ziling Wang et al.

Summary: The study revealed that ginsenoside Rg1 can prevent MSCs from entering senescence state by activating the NRF2 and AKT pathways, enhancing cell antioxidant capacity. This discovery provides new therapeutic targets for preventing cell senescence.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Cell Biology

Panax ginseng-Derived Extracellular Vesicles Facilitate Anti-Senescence Effects in Human Skin Cells: An Eco-Friendly and Sustainable Way to Use Ginseng Substances

Eun-Gyung Cho et al.

Summary: Ginseng-derived EVs have shown the ability to improve senescent phenotypes and melanogenesis in human skin cells, with a unique lipidomic profile compared to parental root extracts. These findings suggest that GEVs could be utilized as novel bioactive nanomaterials for targeted delivery of active constituents in human tissues.

CELLS (2021)

Article Oncology

Inhibitory role of ginsenoside Rb2 in endothelial senescence and inflammation mediated by microRNA-216a

Yutong Chen et al.

Summary: The study demonstrates that ginsenoside Rb2 can potentially inhibit endothelial cell senescence and inflammation by targeting miR-216a, indicating its possible application as a therapeutic drug.

MOLECULAR MEDICINE REPORTS (2021)

Article Nutrition & Dietetics

The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study

Tae-Ha Chung et al.

Summary: The study showed that Korean red ginseng significantly increased the biological aging indicator and antioxidant capacity of postmenopausal women, as well as improved their symptoms of fatigue.

NUTRIENTS (2021)

Article Cardiac & Cardiovascular Systems

Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein-Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis

Guangyao Shi et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

Review Cell Biology

Roles and regulation of histone methylation in animal development

Ashwini Jambhekar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications

Yea Seong Ryu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Review Oncology

Air pollution and DNA methylation: effects of exposure in humans

Christopher F. Rider et al.

CLINICAL EPIGENETICS (2019)

Article Plant Sciences

Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain

Min Kyoung Kim et al.

JOURNAL OF GINSENG RESEARCH (2018)

Review Plant Sciences

Red ginseng monograph

Seung-Ho So et al.

JOURNAL OF GINSENG RESEARCH (2018)

Article Biochemistry & Molecular Biology

Atorvastatin treatment modulates p16 promoter methylation to regulate p16 expression

Boqian Zhu et al.

FEBS JOURNAL (2017)

Review Biochemistry & Molecular Biology

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

Daniela D'Arcangelo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Plant Sciences

Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor

Wai-Nam Sung et al.

JOURNAL OF GINSENG RESEARCH (2017)

Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

Article Medicine, Research & Experimental

Oxidative stress levels are correlated with P15 and P16 gene promoter methylation in myelodysplastic syndrome patients

Ana Cristina Goncalves et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2016)

Article Toxicology

Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure

Natalia D. Magnani et al.

TOXICOLOGICAL SCIENCES (2016)

Article Medicine, Research & Experimental

Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases

Kyung Eun Kim et al.

LIFE SCIENCES (2016)

Article Medicine, General & Internal

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16INK4a) in Cancer

Ran Zhao et al.

EBIOMEDICINE (2016)

Article Dentistry, Oral Surgery & Medicine

High frequency of p16 and p14 promoter hypermethylation and marked telomere instability in salivary gland tumors

Nadja Nikolic et al.

ARCHIVES OF ORAL BIOLOGY (2015)

Article Dermatology

The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption

Tai-Long Pan et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2015)

Article Multidisciplinary Sciences

Increased P16 DNA Methylation in Mouse Thymic Lymphoma Induced by Irradiation

Wengang Song et al.

PLOS ONE (2014)

Article Chemistry, Medicinal

Pharmacodynamics of Ginsenosides: Antioxidant Activities, Activation of Nrf2, and Potential Synergistic Effects of Combinations

Constance Lay Lay Saw et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2012)

Article Biochemistry & Molecular Biology

The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression

Weibin Wang et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Cell Biology

Regulation of chromatin by histone modifications

Andrew J. Bannister et al.

CELL RESEARCH (2011)

Article Multidisciplinary Sciences

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

Shinsuke Ito et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus

Sima Kheradmand Kia et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)