Journal
ANTIOXIDANTS
Volume 12, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/antiox12111923
Keywords
bioimpedance; weight loss; oxidative status; glycemia
Ask authors/readers for more resources
This study aims to investigate the impact of reductions in various body mass components on oxidative, glycemic, and lipid parameters in obese individuals. The results demonstrate that weight loss can decrease cardiovascular risk, improve oxidative status, and reduce markers of oxidative damage. However, the effects on glycemic state vary depending on the specific body mass components. Glycemic status plays a crucial role in weight reduction.
Background: This work aims to study the effect of reductions in various body mass components on the oxidative, glycemic, and lipid parameters of people with obesity (PWO). Methods: A total of 53 PWO underwent a six-month individualized low-calorie diet combined with moderate exercise, during which anthropometric, biochemical, and oxidative parameters were measured. Probands were divided into groups based on weight, visceral fat area (VFA), total body water (TBW), and skeletal muscle mass (SMM) losses. Results: Weight reduction normalizes glycemia, but VFA reduction is less pronounced, while SMM and TBW reductions are more pronounced in patients with higher initial concentrations of glucose and fructosamine. Moreover, changes in oxidative parameters correlate with changes in glucose. Conclusions: Weight loss, regardless of the reduced tissue, decreases cardiovascular risk. We observed a significant change in almost all parameters related to the redox state. In general, parameters responsible for antioxidant action improved, and markers of oxidative damage decreased. Malondialdehyde, lipid peroxides, and total oxidative status levels can be considered biomarkers reflecting only the current severity of reactive oxygen species genesis processes. When considering the glycemic state, the results are not as clear due to the substantial differences between normoglycemic and hyperglycemic patients. Glycemic status is a factor playing a crucial role in weight reduction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available