Related references
Note: Only part of the references are listed.
Review
Biochemistry & Molecular Biology
Zorislava Bajic et al.
Summary: Cardiovascular diseases are primarily caused by homocysteine, with Vitamin B6 playing a significant role in its metabolism. Deficiency in Vitamin B6 may lead to hyperhomocysteinemia, damaging the blood vessel wall and worsening atherosclerosis.
Review
Biochemistry & Molecular Biology
Eva Baranovicova et al.
Summary: H-1 NMR metabolomics is a valuable tool for characterizing the distribution and alterations of metabolites induced by cerebral ischemic injury or its combination with hyperhomocysteinemia. The study found decreased neurotransmitter pool and increased tissue glutamine level in the brain tissue after ischemic injury. Metabolomic alterations were observed in the blood plasma, including decreased glycolytic intermediates and increased plasma ketone bodies. Ischemic preconditioning showed a lower extent of metabolomic changes. In hyperhomocysteinemic models, a decrease in several amino acids in plasma was associated with hippocampal neuropathology.
Article
Biochemistry & Molecular Biology
Sparta Youssef-Saliba et al.
Summary: Homocysteine, unlike cysteine and methionine, can form an activated species called thiolactone and easily reacts with amino acids to form dipeptides, which may explain the introduction of a methionine residue at the start of protein synthesis.
Article
Biochemistry & Molecular Biology
Elena Gerasimova et al.
Summary: This study found that prenatal hyperhomocysteinemia increased the development of migraine-related symptoms and enhanced sensitivity to the migraine trigger nitroglycerin, suggesting that high levels of homocysteine may be a risk factor for migraine development.
Review
Biochemistry & Molecular Biology
Hendrik Nieraad et al.
Summary: Disturbances in one-carbon metabolism can lead to altered levels of homocysteine, potentially contributing to various pathologies. Animal studies suggest a significant impact of high homocysteine on cognitive performance. Despite controversy, preclinical evidence points to a causal link between high homocysteine and cognition-related disorders.
Article
Biochemistry & Molecular Biology
Alma Prtina et al.
Summary: High doses of vitamin D supplementation in psoriatic patients with vitamin D deficiency led to significant improvements in clinical symptoms, reduced levels of Hcy and folate, decreased pro-inflammatory cytokines, and increased anti-inflammatory cytokines. This suggests that vitamin D supplementation could be a potential preventive and therapeutic strategy to reduce systemic inflammation in psoriatic patients.
