Journal
BIOMOLECULES
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biom13081176
Keywords
manganese; neurotoxicity; oxidative stress; mechanisms; C. elegans
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This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity. The review highlights contributions made by Professor Michael Aschner's laboratory in this field of study, which have significantly advanced our understanding of cellular responses to manganese exposure. His research has identified molecular targets of manganese toxicity and explored the role of astrocytes in neurotoxicity, as well as discovered new facets of manganese-induced neurotoxicity using C. elegans.
This literature review focuses on the evidence implicating oxidative stress in the pathogenesis of manganese neurotoxicity. This review is not intended to be a systematic review of the relevant toxicologic literature. Instead, in keeping with the spirit of this special journal issue, this review highlights contributions made by Professor Michael Aschner's laboratory in this field of study. Over the past two decades, his laboratory has made significant contributions to our scientific understanding of cellular responses that occur both in vitro and in vivo following manganese exposure. These studies have identified molecular targets of manganese toxicity and their respective roles in mitochondrial dysfunction, inflammation, and cytotoxicity. Other studies have focused on the critical role astrocytes play in manganese neurotoxicity. Recent studies from his laboratory have used C. elegans to discover new facets of manganese-induced neurotoxicity. Collectively, his body of work has dramatically advanced the field and presents broader implications beyond metal toxicology.
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