Related references
Note: Only part of the references are listed.BCAA insufficiency leads to premature ovarian insufficiency via ceramide-induced elevation of ROS
Xiao Guo et al.
EMBO MOLECULAR MEDICINE (2023)
Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer
Giovanni Tossetta et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2023)
Nrf2 as a Potential Therapeutic Target for Traumatic Brain Injury
P. M. Abdul-Muneer
JOURNAL OF INTEGRATIVE NEUROSCIENCE (2023)
Acute Oxidative Stress Can Paradoxically Suppress Human NRF2 Protein Synthesis by Inhibiting Global Protein Translation
Kaitlin M. Pensabene et al.
ANTIOXIDANTS (2023)
The role of mitochondrial reactive oxygen species in insulin resistance
Anita Ayer et al.
FREE RADICAL BIOLOGY AND MEDICINE (2022)
Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis
Jinwang Li et al.
NUTRIENTS (2022)
Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation
Sharon Baumel-Alterzon et al.
DIABETES (2022)
Role of NRF2 in Ovarian Cancer
Giovanni Tossetta et al.
ANTIOXIDANTS (2022)
Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis
Ya Zhang et al.
BIOMEDICINE & PHARMACOTHERAPY (2022)
A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes
Froukje Vanweert et al.
NATURE COMMUNICATIONS (2022)
Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives
Daniela Maria Tanase et al.
BIOMOLECULES (2022)
Nrf2 Modulation in Breast Cancer
Somayyeh Ghareghomi et al.
BIOMEDICINES (2022)
Nrf2: The Master and Captain of Beta Cell Fate
Sharon Baumel-Alterzon et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)
The pivotal role of Nrf2 activators in adipocyte biology
A. S. Annie-Mathew et al.
PHARMACOLOGICAL RESEARCH (2021)
Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
Chrysovalantou E. Xirouchaki et al.
SCIENCE ADVANCES (2021)
Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance
Jan Gojda et al.
BIOMOLECULES (2021)
Sphingolipids as a Culprit of Mitochondrial Dysfunction in Insulin Resistance and Type 2 Diabetes
Kamila Roszczyc-Owsiejczuk et al.
FRONTIERS IN ENDOCRINOLOGY (2021)
Exercise-Stimulated ROS Sensitive Signaling Pathways in Skeletal Muscle
Jessica Bouviere et al.
ANTIOXIDANTS (2021)
The aetiology and molecular landscape of insulin resistance
David E. James et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)
The Role of Skeletal Muscle in The Pathogenesis of Altered Concentrations of Branched-Chain Amino Acids (Valine, Leucine, and Isoleucine) in Liver Cirrhosis, Diabetes, and Other Diseases
Milan Holecek
PHYSIOLOGICAL RESEARCH (2021)
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis
Elma Zaganjor et al.
CELL REPORTS (2021)
Effects of Aging on Cardiac Oxidative Stress and Transcriptional Changes in Pathways of Reactive Oxygen Species Generation and Clearance
Farhan Rizvi et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)
Nrf2 in adipocytes
Zhendi Wang et al.
ARCHIVES OF PHARMACAL RESEARCH (2020)
Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death
Eduardo Balsa et al.
NATURE COMMUNICATIONS (2020)
β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice
Frank K. Huynh et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)
The Role of the Nrf2 Signaling in Obesity and Insulin Resistance
Shiri Li et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Pathophysiology of Type 2 Diabetes Mellitus
Unai Galicia-Garcia et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Modulating NRF2 in Disease: Timing Is Everything
Matthew Dodson et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)
Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control
Shuya Kasai et al.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2019)
Branched-chain amino acids in disease
Phillip J. White et al.
SCIENCE (2019)
Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass
Andris Elksnis et al.
FRONTIERS IN PHYSIOLOGY (2019)
TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle
Jin-Ho Koh et al.
DIABETES (2019)
Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis
Wendi Teng et al.
NUTRIENTS (2019)
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
Meiyi Zhou et al.
DIABETES (2019)
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
Bhagirath Chaurasia et al.
SCIENCE (2019)
The Paradox of Coenzyme Q10 in Aging
M. Elena Diaz-Casado et al.
NUTRIENTS (2019)
Redox regulation by NRF2 in aging and disease
Cody J. Schmidlin et al.
FREE RADICAL BIOLOGY AND MEDICINE (2019)
Adipogenesis and metabolic health
Alexandra L. Ghaben et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice
Dionysios Chartoumpekis et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2018)
Role of mitochondrial ROS in the brain: from physiology to neurodegeneration
Plamena R. Angelova et al.
FEBS LETTERS (2018)
Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation
Daniel J. Fazakerley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Mitochondrial CoQ deficiency is a common driver of mitochondria! oxidants and insulin resistance
Daniel J. Fazakerley et al.
ELIFE (2018)
β-Cryptoxanthin ameliorates metabolic risk factors by regulating NF-κB and Nrf2 pathways in insulin resistance induced by high-fat diet in rodents
Kazim Sahin et al.
FOOD AND CHEMICAL TOXICOLOGY (2017)
Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice
Joao Paulo Camporez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease
Filippo Scialo et al.
FRONTIERS IN PHYSIOLOGY (2017)
Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation
Hui-Young Lee et al.
DIABETES (2017)
Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice
Naoto Nagata et al.
DIABETES (2017)
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion
Kristin A. Anderson et al.
CELL METABOLISM (2017)
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Courtney R. Green et al.
NATURE CHEMICAL BIOLOGY (2016)
Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production
Paul M. Titchenell et al.
CELL METABOLISM (2016)
A 3-methylcrotonyl-CoA carboxylase deficient human skin fibroblast transcriptome reveals underlying mitochondrial dysfunction and oxidative stress
L. Zandberg et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)
Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism
Akira Uruno et al.
MOLECULAR AND CELLULAR BIOLOGY (2016)
Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism
Carles Lerin et al.
MOLECULAR METABOLISM (2016)
Rising levels of atmospheric oxygen and evolution of Nrf2
Ranko Gacesa et al.
SCIENTIFIC REPORTS (2016)
Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
Rachel J. Perry et al.
CELL (2015)
Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria
Ken Itoh et al.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2015)
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Joshua W. Knowles et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Impaired Adiponectin Signaling Contributes to Disturbed Catabolism of Branched-Chain Amino Acids in Diabetic Mice
Kun Lian et al.
DIABETES (2015)
Branched-chain amino acids in metabolic signalling and insulin resistance
Christopher J. Lynch et al.
NATURE REVIEWS ENDOCRINOLOGY (2014)
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
Amit R. Majithia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome
Peng Xue et al.
DIABETES (2013)
Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
Cristina Menni et al.
DIABETES (2013)
Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice
Jialin Xu et al.
DIABETES (2012)
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Robert A. Scott et al.
NATURE GENETICS (2012)
Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet Induced Insulin Resistance
Yun Sok Lee et al.
DIABETES (2011)
Ceramides as modulators of cellular and whole-body metabolism
Benjamin T. Bikman et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
The genetics of type 2 diabetes: what have we learned from GWAS?
Liana K. Billings et al.
YEAR IN DIABETES AND OBESITY (2010)
Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview
Ken Itoh et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Hyperinsulinemia Precedes Insulin Resistance in Mice Lacking Pancreatic β-Cell Leptin Signaling
Sarah L. Gray et al.
ENDOCRINOLOGY (2010)
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
Michael Ristow et al.
EXPERIMENTAL GERONTOLOGY (2010)
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Ethan J. Anderson et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Sphingolipids Function as Downstream Effectors of a Fungal PAQR
Nancy Y. Villa et al.
MOLECULAR PHARMACOLOGY (2009)
Insulin resistance is a cellular antioxidant defense mechanism
Kyle L. Hoehn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
Sudha B. Biddinger et al.
CELL METABOLISM (2008)
Selective versus total insulin resistance: A pathogenic paradox
Michael S. Brown et al.
CELL METABOLISM (2008)
Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance
K. Sreekumaran Nair et al.
DIABETES (2008)
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet
Yuji Tanaka et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Is mitochondrial dysfunction a cause of insulin resistance?
Nigel Turner et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2008)
Global transcript profiles of fat in monozygotic twins discordant for BMI:: Pathways behind acquired obesity
Kirsi H. Pietilainen et al.
PLOS MEDICINE (2008)
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism
Pengxiang She et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
Jacqui M. Marzec et al.
FASEB JOURNAL (2007)
Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants
Raquel Moreno-Loshuertos et al.
NATURE GENETICS (2006)
Reactive oxygen species have a causal role in multiple forms of insulin resistance
N Houstis et al.
NATURE (2006)
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
KF Petersen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
KF Petersen et al.
SCIENCE (2003)