4.7 Review

The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders

Related references

Note: Only part of the references are listed.
Article Neurosciences

Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson's disease before brain pathology

C. Pellegrini et al.

Summary: This study reveals a series of events that occur early in Parkinson's disease, including bowel inflammation, impaired intestinal epithelial barrier, and dysbiosis. It also finds that early accumulation of intestinal alpha-synuclein compromises the intestinal barrier through the activation of inflammatory response and alters the intestinal microbiota, which may contribute to both bowel symptoms and central pathology.

NPJ PARKINSONS DISEASE (2022)

Review Medicine, Research & Experimental

Molecular pathways associated with oxidative stress and their potential applications in radiotherapy (Review)

Rui Liu et al.

Summary: Radiotherapy is an important treatment modality for cancer. Excessive reactive oxygen species (ROS) induced by radiation disrupt cellular redox homeostasis, leading to oxidative stress and cell death. However, tumor cells have dynamic responses to radiotherapy by activating various cellular signaling pathways. Scavenging excess ROS results in radioresistance and worsened clinical outcomes. Understanding the underlying mechanisms of oxidative stress in radiotherapy is crucial for exploring potential targets and improving treatment efficacy.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2022)

Review Pharmacology & Pharmacy

Mechanisms of Chemotherapy-Induced Neurotoxicity

Halina Was et al.

Summary: Chemotherapeutic drugs are extensively used in cancer treatment, but their severe side effects on the nervous system can reduce the efficacy of treatment and patients' quality of life. This review discusses the main effects of chemotherapy on the peripheral and central nervous systems, including neuropathic pain, chemobrain, enteric neuropathy, as well as nausea and emesis.

FRONTIERS IN PHARMACOLOGY (2022)

Article Multidisciplinary Sciences

SIRT3 activation promotes enteric neurons survival and differentiation

Arun Balasubramaniam et al.

Summary: This study found that honokiol and its derivative hexafluoro-honokiol have a protective effect on enteric neurons, increasing neuronal networks, fiber density, and the expression of relevant genes. Honokiol and its derivative could be potential drugs for treating enteric neurodegeneration and associated disorders.

SCIENTIFIC REPORTS (2022)

Article Biochemistry & Molecular Biology

Oxidative Stress-Induced HMGB1 Translocation in Myenteric Neurons Contributes to Neuropathy in Colitis

Rhian Stavely et al.

Summary: This study investigates the expression of HMGB1 in the enteric nervous system and its relevance to intestinal neuroinflammation. The results suggest that oxidative stimuli induce cytoplasmic translocation of HMGB1 and neuronal loss, which can be ameliorated by inhibiting HMGB1.

BIOMOLECULES (2022)

Review Biochemistry & Molecular Biology

Enteric Neuromyopathies: Highlights on Genetic Mechanisms Underlying Chronic Intestinal Pseudo-Obstruction

Francesca Bianco et al.

Summary: CIPO is a typical clinical phenotype of severe gut dysmotility characterized by changes in neuro-enteric innervation, interstitial cells of Cajal, and smooth muscle cells. Genetic studies have identified several genes associated with CIPO, paving the way for potential targeted therapies for gut dysmotility.

BIOMOLECULES (2022)

Review Biochemistry & Molecular Biology

Stem cell therapy as a promising strategy in necrotizing enterocolitis

Si-Jia Di et al.

Summary: This review discusses the therapeutic mechanisms through which stem cells may function in the treatment of necrotizing enterocolitis (NEC). Animal studies have shown that stem cells have anti-inflammatory, anti-apoptotic, and intestinal barrier enhancing effects, which may be protective against NEC.

MOLECULAR MEDICINE (2022)

Article Biochemistry & Molecular Biology

Chagas Disease Megaesophagus Patients Carrying Variant MRPS18B P260A Display Nitro-Oxidative Stress and Mitochondrial Dysfunction in Response to IFN-γ Stimulus

Karla Deysiree Alcantara Silva et al.

Summary: This study identified harmful mitochondrial gene mutations associated with Chagas disease (CD) patients with chagasic megaesophagus (CME), suggesting a potential link between immune-mediated nitro-oxidative stress and mitochondrial dysfunction in the development of megaesophagus.

BIOMEDICINES (2022)

Proceedings Paper Gastroenterology & Hepatology

Molecular Targets to Alleviate Enteric Neuropathy and Gastrointestinal Dysfunction

Lauren Sahakian et al.

Summary: Structural and functional changes in the enteric nervous system (ENS) result in long-term gastrointestinal dysfunction. Targeting enteric neuropathy through novel therapeutic strategies, such as testing the efficacy of new compounds targeting specific molecular pathways, shows promise in alleviating chronic intestinal disorders.

ENTERIC NERVOUS SYSTEM II (2022)

Review Cell Biology

The mitochondrial stress responses: the Dr. Jekyll and Mr. Hyde of neuronal disorders

Simone Patergnani et al.

Summary: Neuronal disorders are closely associated with the loss of mitochondrial functions, and mitochondria activate stress responses to perceive and control dangerous conditions while rescuing the physiological state of nerve cells. This review primarily discusses the impact of compensatory mitochondrial hyperfusion, mitophagy, mitochondrial unfolding protein response, and apoptosis on neurological diseases, as well as the relevance of mitochondria-mediated inflammatory response in the pathogenesis of these diseases.

NEURAL REGENERATION RESEARCH (2022)

Article Pediatrics

Intrauterine exposure to oxidative stress induces caspase-1-dependent enteric nerve cell pyroptosis

Lingling Zhou et al.

Summary: This study found that oxidative stress may induce enteric nerve cell death by activating caspase-1-dependent pyroptosis through NLRP3 inflammasomes, contributing to abnormal development of the enteric nervous system.

PEDIATRIC SURGERY INTERNATIONAL (2022)

Article Gastroenterology & Hepatology

Irradiation Induces Tuft Cell Hyperplasia and Myenteric Neuronal Loss in the Absence of Dietary Fiber in a Mouse Model of Pelvic Radiotherapy

Ulrikke Voss et al.

Summary: This study aimed to investigate the effects of a diet rich in fermentable fiber on radiation-induced intestinal damage, with a focus on tuft cells and enteric neurons. The results showed that dietary fiber significantly affected intestinal morphometrics in both the short and long term, stimulating the re-emergence of crypt-surface unit structures after irradiation.

GASTROENTEROLOGY INSIGHTS (2022)

Article Gastroenterology & Hepatology

Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis

Lauren Sahakian et al.

Summary: This study demonstrates that targeting APE1/Ref-1 redox activity with APX3330 can alleviate inflammation-induced oxidative stress in a murine model of chronic colitis, improving disease severity, reducing immune cell infiltration, restoring GI function, and providing neuroprotective effects to the enteric nervous system. Inhibition of APE1/Ref-1 redox signaling via APX3330 also reduces mitochondrial superoxide production, oxidative DNA damage, and HMGB1 translocation, suggesting a novel strategy for the treatment of IBD.

INFLAMMATORY BOWEL DISEASES (2021)

Review Biochemistry & Molecular Biology

Oxidative eustress: On constant alert for redox homeostasis

Helmut Sies

Summary: The spatiotemporal control of redox signaling in cells relies on continuous fine-tuning, with molecules like H2O2 playing a key role. Oxidative eustress operates within a specific physiological range, and is managed through both short-term and long-term homeostatic mechanisms to respond to stress.

REDOX BIOLOGY (2021)

Review Biochemistry & Molecular Biology

New insights into targeting mitochondria in ischemic injury

Jingjing Jia et al.

Summary: Stroke is a major cause of disability and death in adults worldwide. Mitochondrial dysfunction plays a crucial role in ischemic stroke, and preserving mitochondrial function is essential for neuronal survival and function maintenance. Damaged mitochondria can trigger neuronal apoptosis, emphasizing the importance of mitochondrial quality control processes in preventing cell death.

APOPTOSIS (2021)

Article Pediatrics

NOX5 is expressed aberrantly but not a critical pathogenetic gene in Hirschsprung disease

Jing Wang et al.

Summary: The study revealed that the expression of NOX5 is significantly decreased in the aganglionic segment of HSCR colon patients. In zebrafish, NOX5 expression seems to be enriched in the nervous system. However, knockdown of NOX5 did not affect the development of the enteric nervous system and gastrointestinal motility in zebrafish.

BMC PEDIATRICS (2021)

Article Clinical Neurology

Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy

Elena Bonora et al.

Summary: Variants in the LIG3 gene result in a mitochondrial disease characterized by predominant gut dysmotility, encephalopathy, and neuromuscular abnormalities. Defects in the LIG3 gene affect mtDNA maintenance and lead to mtDNA depletion.

BRAIN (2021)

Review Biochemistry & Molecular Biology

The antioxidant response in Barrett?s tumorigenesis: A double-edged sword

Dunfa Peng et al.

Summary: Esophageal adenocarcinoma is the dominant form of esophageal malignancies in industrialized countries, mainly associated with Barrett's esophagus as a precancerous condition, with risk factors including GERD, obesity, and smoking. Neoplastic cells adapt to oxidative stress by developing a pro-tumorigenic antioxidant response, promoting tumorigenesis, progression, and therapy resistance.

REDOX BIOLOGY (2021)

Article Cell Biology

Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery

Jiajun Luo et al.

Summary: Detecting oxidative stress levels (MDA) is significantly helpful in diagnosing anastomotic leakage after rectal surgery, with MDA showing similar diagnostic accuracy to CRP and serving as a useful biomarker for early diagnosis.

MEDIATORS OF INFLAMMATION (2021)

Review Biotechnology & Applied Microbiology

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

Henry Jay Forman et al.

Summary: Oxidative stress plays a role in various diseases, and understanding the mechanisms behind antioxidants and how to enhance antioxidant defences may lead to greater pharmacological success.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Oncology

Predicting Colorectal Cancer Occurrence in IBD

Mehmet Yalchin et al.

Summary: Patients with colonic inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and are enrolled into a surveillance programme aimed at detecting dysplasia or early cancer. Current surveillance programmes are guided by clinical, endoscopic or histological predictors of colitis-associated CRC (CA-CRC). There has been significant progress in understanding predictors of disease progression and improvements in endoscopic technique and management, leading to a decrease in the incidence of CA-CRC over the past 50 years. However, there is still room for improvement in our molecular understanding of CA-CRC progression and better risk stratification for patients with IBD.

CANCERS (2021)

Article Oncology

Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway

Di Zeng et al.

Summary: ASP attenuated the 5-FU-induced Nrf2 pathway barrier to reduce oxidative stress injury and inhibit the disorder of lipid anabolism and apoptosis, providing a new protectant and novel target for treating liver injury caused by 5-FU.

FRONTIERS IN ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease

Rhian Stavely et al.

CURRENT DRUG TARGETS (2020)

Article Biochemistry & Molecular Biology

Neurochemical Plasticity of nNOS-, VIP- and CART-Immunoreactive Neurons Following Prolonged Acetylsalicylic Acid Supplementation in the Porcine Jejunum

Dominika Rzap et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Oral mucositis: the hidden side of cancer therapy

Claudio Pulito et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Pharmacology & Pharmacy

Neurochemistry of Enteric Neurons Following Prolonged Indomethacin Administration in the Porcine Duodenum

Marta Czajkowska et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract

Kenton M. Sanders et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Physiology

Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function

Sabine Schneider et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

Article

Peroxynitrite: cellular pathology and implications in autoimmunity

Rizwan Ahmad et al.

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Nitrergic Enteric Neurons in Health and DiseaseFocus on Animal Models

Nikolett Bodi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Gut Microbiota and Cancer: From Pathogenesis to Therapy

Silvia Vivarelli et al.

CANCERS (2019)

Article Gastroenterology & Hepatology

The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis

Isola A. M. Brown et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Gastroenterology & Hepatology

Role of transient receptor potential melastatin 2 in surgical inflammation an dysmotility in a mouse model of postoperative ileus

Kenjiro Matsumoto et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Pharmacology & Pharmacy

Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15

Rachel M. McQuade et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Pharmacology & Pharmacy

Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?

Kulmira Nurgali et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Oncology

The role of cellular reactive oxygen species in cancer chemotherapy

Haotian Yang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Article Biochemistry & Molecular Biology

Ultrastructural characteristics of myenteric plexus in patients with colorectal cancer

Agata Zauszkiewicz-Pawlak et al.

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2017)

Review Medicine, General & Internal

Crohn's disease

Joana Torres et al.

LANCET (2017)

Review Medicine, General & Internal

Ulcerative colitis

Ryan Ungaro et al.

LANCET (2017)

Review Geriatrics & Gerontology

Impact of chemotherapy on gastrointestinal functions and the enteric nervous system

Jonathan Escalante et al.

MATURITAS (2017)

Review Cell Biology

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Tian Tian et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2017)

Review Pharmacology & Pharmacy

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

Patrik Poprac et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Article Surgery

The effect of ozone treatment on experimental colon anastomosis in rats

N. Ersoz et al.

EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA (2016)

Article Gastroenterology & Hepatology

Prucalopride exerts neuroprotection in human enteric neurons

Francesca Bianco et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Article Pharmacology & Pharmacy

Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice

Rachel M. McQuade et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Developmental Biology

Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment

Allan M. Goldstein et al.

DEVELOPMENTAL BIOLOGY (2016)

Article Gastroenterology & Hepatology

DNA Damage and Oxidative DNA Damage in Inflammatory Bowel Disease

Cristiana Pereira et al.

JOURNAL OF CROHNS & COLITIS (2016)

Article Gastroenterology & Hepatology

Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus

G. Farro et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2016)

Article Neurosciences

Sirtuin-3 Is Expressed by Enteric Neurons but It Does not Play a Major Role in Their Regulation of Oxidative Stress

Rebecca K. Bubenheimer et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2016)

Review Pharmacology & Pharmacy

Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments

Rachel M. McQuade et al.

FRONTIERS IN PHARMACOLOGY (2016)

Article Gastroenterology & Hepatology

Enteric Glia Mediate Pathways That Neuron Death in Colitis Through Purinergic Pathways That Require Connexin-43 and Nitric Oxide

Isola A. M. Brown et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2016)

Article Biochemistry & Molecular Biology

Time dependent changes in the intestinal Ca2+ absorption in rats with type I diabetes mellitus are associated with alterations in the intestinal redox state

Maria Rivoira et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Article Biochemistry & Molecular Biology

NADPH Oxidases and Inflammatory Bowel Disease

Giang Lam et al.

CURRENT MEDICINAL CHEMISTRY (2015)

Article Gastroenterology & Hepatology

Colitis Induces Enteric Neurogenesis Through a 5-HT4-dependent Mechanism

Jaime Belkind-Gerson et al.

INFLAMMATORY BOWEL DISEASES (2015)

Article Cell & Tissue Engineering

Allogeneic guinea pig mesenchymal stem cells ameliorate neurological changes in experimental colitis

Rhian Stavely et al.

STEM CELL RESEARCH & THERAPY (2015)

Review Biochemistry & Molecular Biology

Oxidative stress: a concept in redox biology and medicine

Helmut Sies

REDOX BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Joe Dan Dunn et al.

REDOX BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Calcium and ROS: A mutual interplay

Agnes Goerlach et al.

REDOX BIOLOGY (2015)

Article Biology

Reduced neurons in the ileum of proctocolectomized rat models

Chun-Mei Zhao et al.

MEDICAL MOLECULAR MORPHOLOGY (2015)

Article Gastroenterology & Hepatology

Infantile hypertrophic pyloric stenosis (IHPS): A study of its pathophysiology utilizing the newborn hph-1 mouse model of the disease

Christopher Welsh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)

Review Biochemistry & Molecular Biology

Roles of DUOX-Mediated Hydrogen Peroxide in Metabolism, Host Defense, and Signaling

Xavier De Deken et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Endocrinology & Metabolism

Oxidative stress and adrenocortical insufficiency

R. Prasad et al.

JOURNAL OF ENDOCRINOLOGY (2014)

Review Pharmacology & Pharmacy

Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

Aleksandra Piechota-Polanczyk et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2014)

Article Gastroenterology & Hepatology

Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis

John H. Winston et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Gastroenterology & Hepatology

Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability

Christopher B. Forsyth et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Oxidative Damage in Clinical Ischemia/Reperfusion Injury: A Reappraisal

Dorottya K. de Vries et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Article Neurosciences

Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon

Jane A. Roberts et al.

JOURNAL OF PHYSIOLOGY-LONDON (2013)

Article Neurosciences

Effects of oxaliplatin on mouse myenteric neurons and colonic motility

Linah Wafai et al.

FRONTIERS IN NEUROSCIENCE (2013)

Article Obstetrics & Gynecology

May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?

Serafina Perrone et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2012)

Review Gastroenterology & Hepatology

The enteric nervous system and neurogastroenterology

John B. Furness

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

Article Gastroenterology & Hepatology

Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis

Xuan-Zheng Shi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2011)

Review Biochemistry & Molecular Biology

Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling

Imad Al Ghouleh et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Agriculture, Multidisciplinary

Apple Peel Polyphenol Extract Protects against Indomethacin-Induced Damage in Caco-2 Cells by Preventing Mitochondrial Complex I Inhibition

Catalina Carrasco-Pozo et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

Article Pediatrics

Total oxidant status and oxidative stress are increased in infants with necrotizing enterocolitis

Cumhur Aydemir et al.

JOURNAL OF PEDIATRIC SURGERY (2011)

Review Biochemistry & Molecular Biology

Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species

Kyung-Jin Cho et al.

MOLECULES AND CELLS (2011)

Article Gastroenterology & Hepatology

Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress

B. Chandrasekharan et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2011)

Article Gastroenterology & Hepatology

Selective responses of myenteric neurons to oxidative stress and diabetic stimuli

E. Voukali et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2011)

Review Gastroenterology & Hepatology

The involvement of nitric oxide synthase neurons in enteric neuropathies

L. R. Rivera et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2011)

Article Anatomy & Morphology

Chronic Alcohol Consumption Affects Gastrointestinal Motility and Reduces the Proportion of Neuronal NOS-Immunoreactive Myenteric Neurons in the Murine Jejunum

Maria Bagyanszki et al.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Redox-optimized ROS balance: A unifying hypothesis

M. A. Aon et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)

Article Biochemistry & Molecular Biology

Enteric glial cells protect neurons from oxidative stress in part via reduced glutathione

Hind Abdo et al.

FASEB JOURNAL (2010)

Article Biochemistry & Molecular Biology

Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine

Janusz Godlewski

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2010)

Article Gastroenterology & Hepatology

CD206-Positive M2 Macrophages That Express Heme Oxygenase-1 Protect Against Diabetic Gastroparesis in Mice

Kyoung Moo Choi et al.

GASTROENTEROLOGY (2010)

Review Immunology

Neuroinflammation in inflammatory bowel disease

Shaheen E. Lakhan et al.

JOURNAL OF NEUROINFLAMMATION (2010)

Article Surgery

Mesenteric Nitric Oxide and Superoxide Production in Experimental Necrotizing Enterocolitis

Jill S. Whitehouse et al.

JOURNAL OF SURGICAL RESEARCH (2010)

Article Medicine, Research & Experimental

Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury

Asuka Shiota et al.

JOURNAL OF MEDICAL INVESTIGATION (2010)

Article Gastroenterology & Hepatology

Discrete responses of myenteric neurons to structural and functional damage by neurotoxins in vitro

Sandra Lourenssen et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)

Review Biochemistry & Molecular Biology

Redox Signaling Across Cell Membranes

Aron B. Fisher

ANTIOXIDANTS & REDOX SIGNALING (2009)

Review Biochemistry & Molecular Biology

How mitochondria produce reactive oxygen species

Michael P. Murphy

BIOCHEMICAL JOURNAL (2009)

Article Biochemistry & Molecular Biology

Superoxide is the major reactive oxygen species regulating autophagy

Y. Chen et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Pharmacology & Pharmacy

Effects of H2O2 at rat myenteric neurones in culture

Ervice Pouokam et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

Article Cell Biology

Immunohistochemical analysis of neuron types in the mouse small intestine

Zheng-Dong Qu et al.

CELL AND TISSUE RESEARCH (2008)

Article Biochemistry & Molecular Biology

Colonic healing after portal ischemia and reperfusion: an experimental study with oxidative stress biomarkers

Marcia Farias Rolim et al.

REDOX REPORT (2007)

Article Neurosciences

Superoxide (•O2-) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen

Dominic P. D'Agostino et al.

JOURNAL OF NEUROPHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

Effect of hyperoxia on cortical neuronal nuclear function and programmed cell death mechanisms

Eddie Chang et al.

NEUROCHEMICAL RESEARCH (2007)

Review Gastroenterology & Hepatology

Oxidative stress and pathogenesis of inflammatory bowel disease: An epiphenomenon or the cause?

Ali Rezaie et al.

DIGESTIVE DISEASES AND SCIENCES (2007)

Review Nutrition & Dietetics

Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents

Makoto Sasaki et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2007)

Review Biochemistry & Molecular Biology

Free radicals and antioxidants in normal physiological functions and human disease

Marian Valko et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Substance Abuse

Chronic ethanol exposure impairs neuronal nitric oxide synthase in the rat intestine

Monika Krecsmarik et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2006)

Article Gastroenterology & Hepatology

Inflammatory bowel disease: the view of the surgeon

L Hancock et al.

COLORECTAL DISEASE (2006)

Review Biochemistry & Molecular Biology

Novel mechanisms of natural antioxidant compounds in biological systems:: Involvement of glutathione and glutathione-related enzymes

R Masella et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2005)

Article Gastroenterology & Hepatology

Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon

DR Linden et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2005)

Article Gastroenterology & Hepatology

Lipid peroxidation and antioxidant status in colorectal cancer

Elzbieta Skrzydlewska et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2005)

Review Oncology

The pathobiology of mucositis

ST Sonis

NATURE REVIEWS CANCER (2004)

Article Gastroenterology & Hepatology

Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease

IE Koutroubakis et al.

DIGESTIVE DISEASES AND SCIENCES (2004)

Article Biochemistry & Molecular Biology

Oxidative damage and altered antioxidant enzyme activities in the small intestine of streptozotocin-induced diabetic rats

VM Bhor et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)

Article Gastroenterology & Hepatology

Mechanisms of postoperative ileus

AJ Bauer et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2004)

Article Gastroenterology & Hepatology

Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia

R D'Inca et al.

INFLAMMATORY BOWEL DISEASES (2004)

Article Biochemistry & Molecular Biology

Idiosyncratic NSAID drug induced oxidative stress

G Galati et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2002)

Review Physiology

Heme oxygenase: colors of defense against cellular stress

LE Otterbein et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2000)

Article Gastroenterology & Hepatology

Actions of reactive oxygen species on AH/type 2 myenteric neurons in guinea pig distal colon

S Wada-Takahashi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)

Article Surgery

Role of stasis and oxidative stress in ileal pouch inflammation

KO Shebani et al.

JOURNAL OF SURGICAL RESEARCH (2000)