Journal
NATURE CHEMISTRY
Volume 9, Issue 4, Pages 333-340Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.2686
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Funding
- University of California, Los Angeles (UCLA) Department of Chemistry and Biochemistry
- 3M
- American Chemical Society Petroleum Research Fund [56562-DNI3]
- US Public Health Service of the National Institutes of Health (NIH) through the UCLA Chemistry-Biology Interface Training Program under the National Research Service Award [T32GM008496]
- CARE Scholars Programs (NIH grant) [GM055052]
- National Science Foundation (NSF)
- NSF Division of Materials Research grant [1506886]
- NSF [CHE-1507735, CHE-1048804]
- NIH [1S10RR23057, 1S10OD016387-01]
- Direct For Mathematical & Physical Scien [1507735] Funding Source: National Science Foundation
- Division Of Chemistry [1507735] Funding Source: National Science Foundation
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The majority of biomolecules are intrinsically atomically precise, an important characteristic that enables rational engineering of their recognition and binding properties. However, imparting a similar precision to hybrid nanoparticles has been challenging because of the inherent limitations of existing chemical methods and building blocks. Here we report a new approach to form atomically precise and highly tunable hybrid nanomolecules with well-defined three-dimensionality. Perfunctionalization of atomically precise clusters with pentafluoroaryl-terminated linkers produces size-tunable rigid cluster nanomolecules. These species are amenable to facile modification with a variety of thiol-containing molecules and macromolecules. Assembly proceeds at room temperature within hours under mild conditions, and the resulting nanomolecules exhibit high stabilities because of their full covalency. We further demonstrate how these nanomolecules grafted with saccharides can exhibit dramatically improved binding affinity towards a protein. Ultimately, the developed strategy allows the rapid generation of precise molecular assemblies to investigate multivalent interactions.
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