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Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021-2023)

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Lipid poly (ε-caprolactone) hybrid nanoparticles of 5-fluorouracil for sustained release and enhanced anticancer efficacy

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Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

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In vitro anti-leukemic assessment and sustained release behaviour of cytarabine loaded biodegradable polymer based nanoparticles

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Summary: The study aimed to develop and evaluate PCL nanoparticles loaded with cytarabine for sustained release behavior and anti-leukemic influence. The developed nanoparticles showed efficient toxicity against leukemic and breast cancer cell lines, with sustained release pattern enhancing the anti-cancer effects.

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Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles

Jamie K. Hu et al.

Summary: The development of a bioadhesive nanoparticle (BNP) drug delivery system significantly increased the therapeutic efficacy of intratumoral drug delivery by enhancing binding to SCC tumor cell surfaces and matrix proteins. In a mouse model, BNP-CPT markedly reduced tumor burden and showed signs of histologic cure in a portion of the lesions.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Interactions between Biomedical Micro-/Nano-Motors and the Immune Molecules, Immune Cells, and the Immune System: Challenges and Opportunities

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Summary: Mobile micro- and nano-motors (MNMs) are revolutionary platforms for biomedical applications, but their interactions with the immune system are crucial. By surpassing immune barriers and leveraging immune components, MNMs can achieve cancer immunotherapy, immunoassay, and detoxification, presenting novel opportunities for the biomedical field through interdisciplinary cooperation.

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Anticancer effects against colorectal cancer models of chloro(triethylphosphine)gold(I) encapsulated in PLGA-PEG nanoparticles

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Summary: Encapsulation of Et3PAuCl in biocompatible PLGA-PEG nanoparticles led to increased cytotoxic effects in colorectal cancer cells, mediated by apoptosis and autophagy, as well as significant inhibition of the ERK and AKT signaling pathways. These findings suggest potential for nano-Et3PAuCl as an improved anticancer drug candidate.

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Summary: The physical morphologies of nanoparticles significantly influence their biological behaviors, and smart transformable nanomaterials show great potential in advanced tumor theranostics.

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Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

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Summary: Polylactide (PLA) is a common biodegradable polymer with sustainable, eco-friendly, and fully biodegradable properties. Stereocomplex PLA (sc-PLA) has improved mechanical and physical strength compared to homopolymers, making it suitable for applications in drug delivery systems.

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Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance

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Summary: This review summarizes the recent advances in important cancer-related ABC transporters, focusing on their physiological functions, structures, and the development of new compounds as ABC transporter inhibitors, highlighting the potential use of modulators to enhance the therapeutic efficacy of chemotherapy drugs.

FRONTIERS IN PHARMACOLOGY (2021)

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Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core-shell nanoparticles as a stimuli-responsive drug delivery system

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NATURE BIOMEDICAL ENGINEERING (2021)

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Medicine, Research & Experimental

Combining Gemcitabine-Loaded Macrophage-like Nanoparticles and Erlotinib for Pancreatic Cancer Therapy

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Summary: The combination of gemcitabine-loaded PLGA nanoparticles with a macrophage membrane coating showed promising results in reducing drug toxicity, improving tumor accumulation, and inhibiting pancreatic cancer cell proliferation through targeting signaling pathways. This approach provides potential synergistic anti-tumor efficacy for treating pancreatic cancer.

MOLECULAR PHARMACEUTICS (2021)

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Cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with the United States and United Kingdom based on the global epidemiological data released in 2020

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Summary: Cancer is a major cause of death and economic burden in China, with lower incidence but higher mortality and DALY rates compared to the US and UK. The cancer spectrum in China is changing, with increasing burden of certain cancers and a shift towards patterns seen in developed countries.

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Article Pharmacology & Pharmacy

Docetaxel loaded mPEG-PLA nanoparticles for sarcoma therapy: preparation, characterization, pharmacokinetics, and anti-tumor efficacy

Jianhua Chen et al.

Summary: This study aimed to improve the efficacy of docetaxel by incorporating it into mPEG-PLA nanoparticles for the treatment of sarcoma. The optimized DTX NP showed significant improvements in drug release, pharmacokinetics, and anti-tumor efficacy compared to DTX injection, demonstrating potential for application in sarcoma treatment.

DRUG DELIVERY (2021)

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Article Chemistry, Multidisciplinary

Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery

Pan Zheng et al.

CHINESE CHEMICAL LETTERS (2020)

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Review Chemistry, Multidisciplinary

Polyester based polymeric nano and microparticles for pharmaceutical purposes: A review on formulation approaches

Fatima Molavi et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

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Article Chemistry, Physical

The dose threshold for nanoparticle tumour delivery

Ben Ouyang et al.

NATURE MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Development of High-Drug-Loading Nanoparticles

Yun Liu et al.

CHEMPLUSCHEM (2020)

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Review Biochemistry & Molecular Biology

Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance

Yihan Yao et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Polymer Science

Gemcitabine-Loaded Magnetically Responsive Poly(ε-caprolactone) Nanoparticles against Breast Cancer

Gracia Garcia-Garcia et al.

POLYMERS (2020)

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Review Biotechnology & Applied Microbiology

Polylactic acid: synthesis and biomedical applications

M. S. Singhvi et al.

JOURNAL OF APPLIED MICROBIOLOGY (2019)

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Article Medicine, Research & Experimental

An acellular tissue matrix-based drug carriers with dual chemo-agents for colon cancer growth suppression

Changfu Qin et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Chemistry, Multidisciplinary

Transcytosis of Nanomedicine for Tumor Penetration

Yan Liu et al.

NANO LETTERS (2019)

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Article Chemistry, Multidisciplinary

Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles

Ruixiang Li et al.

NANO LETTERS (2019)

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Review Biotechnology & Applied Microbiology

Delivery technologies for cancer immunotherapy

Rachel S. Riley et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Review Psychology, Clinical

Fear of cancer recurrence: A qualitative systematic review and meta-synthesis of patients' experiences

Susana N. Almeida et al.

CLINICAL PSYCHOLOGY REVIEW (2019)

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Review Public, Environmental & Occupational Health

Current Cancer Epidemiology

Camilla Mattiuzzi et al.

JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH (2019)

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Article Engineering, Biomedical

PCL and PCL-based materials in biomedical applications

Elbay Malikmammadov et al.

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION (2018)

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Article Nanoscience & Nanotechnology

Biodegradable Drug-Loaded Hydroxyapatite Nanotherapeutic Agent for Targeted Drug Release in Tumors

Wen Sun et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Multidisciplinary

PLGA Spherical Nucleic Acids

Shengshuang Zhu et al.

ADVANCED MATERIALS (2018)

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Review Oncology

The biology and role of CD44 in cancer progression: therapeutic implications

Chen Chen et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Review Materials Science, Biomaterials

Polyester micelles for drug delivery and cancer theranostics: Current achievements, progresses and future perspectives

Yu Yi et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Review Materials Science, Biomaterials

Polyester based nanovehicles for siRNA delivery

Zejun Xu et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Article Multidisciplinary Sciences

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

Jacob S. Brenner et al.

NATURE COMMUNICATIONS (2018)

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Review Materials Science, Biomaterials

Polyester-based nanoparticles for nucleic acid delivery

Jing Zhao et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Review Nanoscience & Nanotechnology

Recent advances in aliphatic polyesters for drug delivery applications

Katherine E. Washington et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2017)

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Review Biotechnology & Applied Microbiology

Application of nanostructured drug delivery systems in immunotherapy of cancer: a review

Nahideh Asadi et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Fabrication of biodegradable PEG-PLA nanospheres for solubility, stabilization, and delivery of curcumin

Hongying Liang et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2017)

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Article Biochemistry & Molecular Biology

Lactobacillus sps. lipase mediated poly (ε-caprolactone) degradation

Imran Khan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Review Pharmacology & Pharmacy

The effect of particle shape on cellular interaction and drug delivery applications of micro-and nanoparticles

Anil B. Jindal

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Review Chemistry, Multidisciplinary

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application

Philip Grossen et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Oncology

An Open-Label, Randomized, Parallel, Phase Ill Trial Evaluating the Efficacy and Safety of Polymeric Micelle-Formulated Paclitaxel Compared to Conventional Cremophor EL-Based Paclitaxel for Recurrent or Metastatic HER2-Negative Breast Cancer

In Hae Park et al.

CANCER RESEARCH AND TREATMENT (2017)

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Article Engineering, Biomedical

Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery

Anne-Laure Papa et al.

BIOMATERIALS (2017)

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Article Engineering, Biomedical

Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly (ε-caprolactone) micelles

Ya Fang et al.

ACTA BIOMATERIALIA (2017)

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Review Pharmacology & Pharmacy

Poly(lactic acid) for delivery of bioactive macromolecules

Roshan James et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Pharmacology & Pharmacy

In vitro toxicity assessment of oral nanocarriers

Silvia Gabriella Ciappellano et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Pharmacology & Pharmacy

PLA composites: From production to properties

Marius Murariu et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Pharmacology & Pharmacy

PLA micro- and nano-particles

Byung Kook Lee et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Review Oncology

Chemotherapy remains an essential element of personalized care for persons with lung cancers

M. D. Hellmann et al.

ANNALS OF ONCOLOGY (2016)

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Article Chemistry, Multidisciplinary

PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels for drug delivery

Hyunah Cho et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Chemistry, Multidisciplinary

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

F. Danhier

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Materials Science, Biomaterials

Paclitaxel molecularly imprinted polymer-PEG-folate nanoparticles for targeting anticancer delivery: Characterization and cellular cytotoxicity

Mehdi Esfandyari-Manesh et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2016)

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Review Engineering, Chemical

Polyol-based biodegradable polyesters: a short review

Weng Hong Tham et al.

REVIEWS IN CHEMICAL ENGINEERING (2016)

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Article Nanoscience & Nanotechnology

Analysis of nanoparticle delivery to tumours

Stefan Wilhelm et al.

NATURE REVIEWS MATERIALS (2016)

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Article Biochemistry & Molecular Biology

Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer

Sanjeev K. Pandey et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Pharmacology & Pharmacy

Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting

Rajan Swami et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Nanoscience & Nanotechnology

Smart Nanoparticles Based on Hyaluronic Acid for Redox-Responsive and CD44 Receptor-Mediated Targeting of Tumor

Hyung-Kyu Park et al.

NANOSCALE RESEARCH LETTERS (2015)

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Editorial Material Cell Biology

Nanomedicine gets personal

Gregory T. Tietjen et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Editorial Material Materials Science, Biomaterials

Polymeric biomaterials for cancer nanotechnology

Jianjun Cheng et al.

BIOMATERIALS SCIENCE (2015)

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Article Nanoscience & Nanotechnology

Smart Nanoparticles Based on Hyaluronic Acid for Redox-Responsive and CD44 Receptor-Mediated Targeting of Tumor

Hyung-Kyu Park et al.

NANOSCALE RESEARCH LETTERS (2015)

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Review Pharmacology & Pharmacy

The importance of nanoparticle shape in cancer drug delivery

Nghia P. Truong et al.

EXPERT OPINION ON DRUG DELIVERY (2015)

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Review Biochemistry & Molecular Biology

Polyester-Based (Bio)degradable Polymers as Environmentally Friendly Materials for Sustainable Development

Joanna Rydz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

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Review Medicine, Research & Experimental

Colon cancer: Cancer stem cells markers, drug resistance and treatment

Zuzana Kozovska et al.

BIOMEDICINE & PHARMACOTHERAPY (2014)

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Article Pharmacology & Pharmacy

ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development

Young Hee Choi et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

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Article Pharmacology & Pharmacy

Influence of particle geometry and PEGylation on phagocytosis of particulate carriers

Roman Mathaes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Review Chemistry, Multidisciplinary

EPR: Evidence and fallacy

Joseph W. Nichols et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Review Chemistry, Multidisciplinary

Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

Hiroshi Maeda

JOURNAL OF CONTROLLED RELEASE (2012)

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Article Chemistry, Multidisciplinary

How Shape Influences Uptake: Interactions of Anisotropic Polymer Nanoparticles and Human Mesenchymal Stem Cells

Laura Florez et al.

SMALL (2012)

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Review Pharmacology & Pharmacy

A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: A strategy for overcoming the PEG dilemma

Hiroto Hatakeyama et al.

ADVANCED DRUG DELIVERY REVIEWS (2011)

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Review Biochemistry & Molecular Biology

Nanomaterials for cancer therapy and imaging

Ki Hyun Bae et al.

MOLECULES AND CELLS (2011)

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Article Oncology

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting-Chao Chou

CANCER RESEARCH (2010)

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Review Biophysics

Biodegradable polymeric nanoparticles based drug delivery systems

Avnesh Kumari et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2010)

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Review Chemistry, Multidisciplinary

Synthesis of functionalized biodegradable polyesters

Charlotte K. Williams

CHEMICAL SOCIETY REVIEWS (2007)

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Article Oncology

Docetaxel-based chemotherapy in the treatment of gastric cancer

AD Roth et al.

ANNALS OF ONCOLOGY (2003)

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Article Multidisciplinary Sciences

Biodegradable polymers for the environment

RA Gross et al.

SCIENCE (2002)

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