4.7 Article

Cytotoxic necrotizing factor 1 hinders colon tumorigenesis induced by colibactin-producing Escherichia coli in ApcMin/+ mice

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Amina Iftekhar et al.

Summary: Genotoxic colibactin-producing pks+ Escherichia coli infection induces characteristics of colorectal cancer cells in organoids, including enhanced proliferation, Wnt independence, and impaired differentiation. Mutations in genes related to the p53 pathway contribute to Wnt-independence in these organoids, suggesting a functional interplay between p53 and Wnt pathways in promoting transformation. The basis of transformation in these organoids is proposed to be larger chromosomal alterations and aneuploidy, consistent with the early appearance of chromosomal instability in colorectal cancer.

NATURE COMMUNICATIONS (2021)

Article Food Science & Technology

CTX-CNF1 Recombinant Protein Selectively Targets Glioma Cells In Vivo

Eleonora Vannini et al.

Summary: The chimeric protein CTX-CNF1 shows potential as a novel effective tool for treating gliomas, targeting tumor cells and extending survival in mice by crossing the blood-brain barrier.

TOXINS (2021)

Article Genetics & Heredity

GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms

Yuli T. Magalhaes et al.

Summary: The classical small Rho GTPase protein family plays crucial roles in regulating cell functions, including maintaining genomic stability and participating in DNA damage response. Studies have shown that direct modulation of Rho GTPase activity, its downstream effectors, and actin cytoskeleton regulation can impact cellular events.

DNA REPAIR (2021)

Article Oncology

Colibactin-Producing Escherichia coli Induce the Formation of Invasive Carcinomas in a Chronic Inflammation-Associated Mouse Model

Laurene Salesse et al.

Summary: Colorectal cancer patients show changes in intestinal flora with an increase in harmful bacteria such as Escherichia coli, which can cause DNA damage. Autophagy is a crucial cell defense mechanism that inhibits tumorigenesis. Targeting autophagy may be a promising strategy to counteract the protumoral effects of bacteria like E. coli producing colibactin.

CANCERS (2021)

Article Multidisciplinary Sciences

Mutational signature in colorectal cancer caused by genotoxic pks+E. coli

Cayetano Pleguezuelos-Manzano et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer

Paulina J. Dziubanska-Kusibab et al.

NATURE MEDICINE (2020)

Review Microbiology

Pathogenicity Factors of Genomic Islands in Intestinal and ExtraintestinalEscherichia coli

Mickael Desvaux et al.

FRONTIERS IN MICROBIOLOGY (2020)

Review Biochemistry & Molecular Biology

An overview of the role of interleukin-8 in colorectal cancer

Soroush Najdaghi et al.

CYTOKINE (2020)

Review Oncology

The Intestinal Microbiota in Colorectal Cancer

Herbert Tilg et al.

CANCER CELL (2018)

Review Biochemistry & Molecular Biology

The Human Gut Microbiome: From Association to Modulation

Thomas S. B. Schmidt et al.

Review Genetics & Heredity

RhoB: Team Oncogene or Team Tumor Suppressor?

Julia A. Ju et al.

GENES (2018)

Review Biochemistry & Molecular Biology

Microbiota, Inflammation and Colorectal Cancer

Cecily Lucas et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Oncology

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

Lu Zhang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Review Oncology

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

Lu Zhang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Gastroenterology & Hepatology

Gut microbiota imbalance and colorectal cancer

Johan Gagniere et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Multidisciplinary Sciences

Gut microbiome development along the colorectal adenoma-carcinoma sequence

Qiang Feng et al.

NATURE COMMUNICATIONS (2015)

Article Immunology

The Bacteroides fragilis Toxin Gene Is Prevalent in the Colon Mucosa of Colorectal Cancer Patients

Annemarie Boleij et al.

CLINICAL INFECTIOUS DISEASES (2015)

Article Oncology

Colonization of the Human Gut by E. coli and Colorectal Cancer Risk

Mathilde Bonnet et al.

CLINICAL CANCER RESEARCH (2014)

Article Gastroenterology & Hepatology

The bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironment

Guillaume Dalmasso et al.

GUT MICROBES (2014)

Article Biochemistry & Molecular Biology

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1

Stefanie C. Huelsenbeck et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Sergei I. Grivennikov et al.

NATURE (2012)

Article Multidisciplinary Sciences

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

Janelle C. Arthur et al.

SCIENCE (2012)

Article Cell Biology

CREG1 enhances p16INK4a-induced cellular senescence

Benchamart Moolmuang et al.

CELL CYCLE (2011)

Article Medicine, Research & Experimental

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

Christophe Ginestier et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Microbiology

Cyclomodulins in Urosepsis Strains of Escherichia coli

Damien Dubois et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2010)

Review Microbiology

The population genetics of commensal Escherichia coli

Olivier Tenaillon et al.

NATURE REVIEWS MICROBIOLOGY (2010)

Article Multidisciplinary Sciences

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

Gabriel Cuevas-Ramos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Escherichia coli induces DNA double-strand breaks in eukaryotic cells

Jean-Philippe Nougayrede et al.

SCIENCE (2006)

Review Biochemistry & Molecular Biology

Cyclomodulins:: bacterial effectors that modulate the eukaryotic cell cycle

JP Nougayrède et al.

TRENDS IN MICROBIOLOGY (2005)

Article Biochemistry & Molecular Biology

A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans

Marie-Kim Chaveroche et al.

NUCLEIC ACIDS RESEARCH (2000)

Article Biochemistry & Molecular Biology

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

Z Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Multidisciplinary Sciences

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

KA Datsenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)