Sinking while you swim: A dual role for CCR7 in leukocyte migration

The CCR7 receptor allows dendritic cells to sense the chemokine CCL19. It also depletes CCL19 from the environment by endocytosis, leading to local gradients that can steer cells accurately and robustly through tissues, even over long distances (see related Research Article by Alanko et al.).

Automated summary

The CCR7 receptor enables dendritic cells to detect CCL19 chemokine and internalize it, creating local gradients that facilitate accurate and robust cell migration through tissues, even over long distances. (see related Research Article by Alanko et al.)