Journal
NATURE CHEMICAL BIOLOGY
Volume 13, Issue 1, Pages 18-20Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.2228
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Funding
- Medical Research Council Career Development Award [G1000526]
- Bank of Butterfield Foundation in Bermuda
- Lorraine University [UMR 7365]
- European Alternative Splicing Network of Excellence (EURASNET, FP6 life sciences, genomics and biotechnology for health) [LSHG-CT-2005-518238]
- CNRS
- Medical Research Council [G1000526] Funding Source: researchfish
- MRC [G1000526] Funding Source: UKRI
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RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions.
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