Journal
NATURE CHEMICAL BIOLOGY
Volume 12, Issue 10, Pages 773-775Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.2157
Keywords
-
Categories
Funding
- China Ocean Mineral Resources Research and Development Association [13.5]
- NIH [R01-GM85770]
Ask authors/readers for more resources
Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available