Journal
NATURE CHEMICAL BIOLOGY
Volume 12, Issue 3, Pages 138-140Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.2002
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Funding
- National Security Science and Engineering Faculty Fellowship [FA9550-10-1-0169]
- Welch Foundation [F-1654]
- Defense Advanced Research Projects Agency [N66001-14-2-4051, HR0011-15-C0095]
- Air Force Office of Scientific Research grant [FA9550-14-1-0089]
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Engineered orthogonal translation systems have greatly enabled the expansion of the genetic code using noncanonical amino acids (NCAAs). However, the impact of NCAAs on organismal evolution remains unclear, in part because it is difficult to force the adoption of new genetic codes in organisms. By reengineering TEM-1 beta-lactamase to be dependent on a NCAA, we maintained bacterial NCAA dependence for hundreds of generations without escape.
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