Journal
NATURE CHEMICAL BIOLOGY
Volume 12, Issue 11, Pages 899-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.2173
Keywords
-
Categories
Funding
- National Science and Engineering Research Council (NSERC) of Canada
- National Institutes of Health [R01 GM094263]
Ask authors/readers for more resources
The essential human enzyme O-linked beta-N-acetylglucosamine transferase (OGT), known for modulating the functions of nuclear and cytoplasmic proteins through serine and threonine glycosylation, was unexpectedly implicated in the proteolytic maturation of the cell cycle regulator host cell factor-1 (HCF-1). Here we show that HCF-1 cleavage occurs via glycosylation of a glutamate side chain followed by on-enzyme formation of an internal pyroglutamate, which undergoes spontaneous backbone hydrolysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available